"How focal seizures initiate and evolve in human neocortex remains a fundamental problem in neuroscience. Here, we use biophysical neuronal network models of neocortical patches to study how the interaction between inhibition and extracellular potassium ([K+]o) dynamics may contribute to different types of focal seizures. Three main types of propagated focal seizures observed in recent intracortical microelectrode recordings in humans were modelled ..."
Model Type: Realistic Network
Region(s) or Organism(s): Neocortex
Cell Type(s): Abstract single compartment conductance based cell
Currents: I K,Ca; I Sodium; I_AHP; I Potassium; I Calcium
Model Concept(s): Bursting; Delay; Epilepsy; Ion Channel Kinetics; Potassium buffering; Gamma oscillations
Simulation Environment: C or C++ program
Implementer(s): Ho, E [ernest_ho at brown.edu]
References:
Truccolo W, Ho EC. (2016). Interaction between Synaptic Inhibition and Glial-Potassium Dynamics leads to Diverse Seizure Transition Modes in Biophysical Models of Human Focal Seizures J Comput Neurosci.