DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)

We present computational models for an Abeta-LTMR (low-threshold mechanoreceptor) and a C-LTMR expressing four Na channels and four K channels to investigate how the expression level of Kv1 and Kv4 regulate number of spikes (repetitive firing) and onset latency to action potentials in Abeta-LTMRs and C-LTMRs, respectively.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Mouse

Cell Type(s): Dorsal Root Ganglion (DRG) cell

Currents: I Sodium; I Potassium; I K; I A

Genes: Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv2.1 KCNB1; Kv3.1 KCNC1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.3 KCND3

Model Concept(s): Action Potential Initiation; Action Potentials; Activity Patterns; Delay; Ion Channel Kinetics; Membrane Properties

Simulation Environment: NEURON; R

Implementer(s): Zheng, Yang [zylittlep at gmail.com]; Bean, Bruce [bruce_bean at hms.harvard.edu]


Zheng Y et al. (2019). Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties Neuron