Ibañez S, Luebke JI, Chang W, Draguljić D, Weaver CM. (2019). Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys. Frontiers in computational neuroscience. 13 [PubMed]

See more from authors: Ibañez S · Luebke JI · Chang W · Draguljić D · Weaver CM

References and models cited by this paper

Albert M. (1993). Neuropsychological and neurophysiological changes in healthy adult humans across the age range. Neurobiology of aging. 14 [PubMed]

Amatrudo JM et al. (2012). Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Amit DJ, Bernacchia A, Yakovlev V. (2003). Multiple-object working memory--a model for behavioral performance. Cerebral cortex (New York, N.Y. : 1991). 13 [PubMed]

Arnsten AF, Wang MJ, Paspalas CD. (2012). Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron. 76 [PubMed]

Bach ME et al. (1999). Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 96 [PubMed]

Barak O, Tsodyks M. (2014). Working models of working memory. Current opinion in neurobiology. 25 [PubMed]

Bowley MP, Cabral H, Rosene DL, Peters A. (2010). Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey. The Journal of comparative neurology. 518 [PubMed]

Braitenberg V, Schuz A. (1991). Anatomy of the Cortex: Statistics and Geometry.

Brunel N. (2003). Dynamics and plasticity of stimulus-selective persistent activity in cortical network models. Cerebral cortex (New York, N.Y. : 1991). 13 [PubMed]

Chaisangmongkon W, Swaminathan SK, Freedman DJ, Wang XJ. (2017). Computing by Robust Transience: How the Fronto-Parietal Network Performs Sequential, Category-Based Decisions. Neuron. 93 [PubMed]

Chang YM, Rosene DL, Killiany RJ, Mangiamele LA, Luebke JI. (2005). Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cerebral cortex (New York, N.Y. : 1991). 15 [PubMed]

Cleeland C, Pipingas A, Scholey A, White D. (2019). Neurochemical changes in the aging brain: A systematic review. Neuroscience and biobehavioral reviews. 98 [PubMed]

Compte A, Brunel N, Goldman-Rakic PS, Wang XJ. (2000). Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. Cerebral cortex (New York, N.Y. : 1991). 10 [PubMed]

Constantinidis C et al. (2018). Persistent Spiking Activity Underlies Working Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Constantinidis C, Qi XL. (2018). Representation of Spatial and Feature Information in the Monkey Dorsal and Ventral Prefrontal Cortex. Frontiers in integrative neuroscience. 12 [PubMed]

Coskren PJ et al. (2015). Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. Journal of computational neuroscience. 38 [PubMed]

Darian-Smith C, Lilak A, Alarcón C. (2013). Corticospinal sprouting occurs selectively following dorsal rhizotomy in the macaque monkey. The Journal of comparative neurology. 521 [PubMed]

Davis SW, Luber B, Murphy DLK, Lisanby SH, Cabeza R. (2017). Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function. Human brain mapping. 38 [PubMed]

Duan H et al. (2003). Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys. Cerebral cortex (New York, N.Y. : 1991). 13 [PubMed]

Edin F et al. (2009). Mechanism for top-down control of working memory capacity. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Engle JR et al. (2016). Network Patterns Associated with Navigation Behaviors Are Altered in Aged Nonhuman Primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]

Fisk JE, Sharp CA. (2004). Age-related impairment in executive functioning: updating, inhibition, shifting, and access. Journal of clinical and experimental neuropsychology. 26 [PubMed]

Foster TC. (2007). Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging cell. 6 [PubMed]

Funahashi S. (2017). Working Memory in the Prefrontal Cortex. Brain sciences. 7 [PubMed]

Gant JC et al. (2014). FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? European journal of pharmacology. 739 [PubMed]

Gant JC et al. (2015). Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Gant JC et al. (2011). Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Gao E, Zhang C, Wang J. (2019). Effects of Budesonide Combined with Noninvasive Ventilation on PCT, sTREM-1, Chest Lung Compliance, Humoral Immune Function and Quality of Life in Patients with AECOPD Complicated with Type II Respiratory Failure. Open medicine (Warsaw, Poland). 14 [PubMed]

Goldman-Rakic PS. (1995). Cellular basis of working memory. Neuron. 14 [PubMed]

Goodliffe JW et al. (2018). Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PloS one. 13 [PubMed]

Hansel D, Mato G. (2013). Short-term plasticity explains irregular persistent activity in working memory tasks. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Hempel CM, Hartman KH, Wang XJ, Turrigiano GG, Nelson SB. (2000). Multiple forms of short-term plasticity at excitatory synapses in rat medial prefrontal cortex. Journal of neurophysiology. 83 [PubMed]

Herndon JG, Moss MB, Rosene DL, Killiany RJ. (1997). Patterns of cognitive decline in aged rhesus monkeys. Behavioural brain research. 87 [PubMed]

Hestrin S, Sah P, Nicoll RA. (1990). Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices. Neuron. 5 [PubMed]

Hodgkin AL, Huxley AF. (1990). A quantitative description of membrane current and its application to conduction and excitation in nerve. 1952. Bulletin of mathematical biology. 52 [PubMed]

Hof PR et al. (2002). Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys. Brain research. 928 [PubMed]

Hof PR, Morrison JH. (2004). The aging brain: morphomolecular senescence of cortical circuits. Trends in neurosciences. 27 [PubMed]

Itskov V, Hansel D, Tsodyks M. (2011). Short-Term Facilitation may Stabilize Parametric Working Memory Trace. Frontiers in computational neuroscience. 5 [PubMed]

Izhikevich EM. (2003). Simple model of spiking neurons. IEEE transactions on neural networks. 14 [PubMed]

King BR et al. (2018). Age-Related Declines in Motor Performance are Associated With Decreased Segregation of Large-Scale Resting State Brain Networks. Cerebral cortex (New York, N.Y. : 1991). 28 [PubMed]

Koen JD, Hauck N, Rugg MD. (2019). The Relationship between Age, Neural Differentiation, and Memory Performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]

Konar A, Singh P, Thakur MK. (2016). Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues. Aging and disease. 7 [PubMed]

Kubicki M et al. (2019). Lifespan Trajectories of White Matter Changes in Rhesus Monkeys. Cerebral cortex (New York, N.Y. : 1991). 29 [PubMed]

Lacreuse A et al. (2005). Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta). Behavioral neuroscience. 119 [PubMed]

Lee A, Tan M, Qiu A. (2016). Distinct Aging Effects on Functional Networks in Good and Poor Cognitive Performers. Frontiers in aging neuroscience. 8 [PubMed]

Luebke J, Barbas H, Peters A. (2010). Effects of normal aging on prefrontal area 46 in the rhesus monkey. Brain research reviews. 62 [PubMed]

Luebke JI, Amatrudo JM. (2012). Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognition. Neurobiology of aging. 33 [PubMed]

Luebke JI, Chang YM, Moore TL, Rosene DL. (2004). Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex. Neuroscience. 125 [PubMed]

Luebke JI et al. (2015). Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Lundqvist M, Herman P, Lansner A. (2011). Theta and gamma power increases and alpha/beta power decreases with memory load in an attractor network model. Journal of cognitive neuroscience. 23 [PubMed]

Lundqvist M, Herman P, Miller EK. (2018). Working Memory: Delay Activity, Yes! Persistent Activity? Maybe Not. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Maass W, Natschläger T, Markram H. (2002). Real-time computing without stable states: a new framework for neural computation based on perturbations. Neural computation. 14 [PubMed]

Mangiafico S. (2016). Summary and Analysis of Extension Program Evaluation in .

Marvel CL, Morgan OP, Kronemer SI. (2019). How the motor system integrates with working memory. Neuroscience and biobehavioral reviews. 102 [PubMed]

McDougal RA et al. (2017). Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience. Journal of computational neuroscience. 42 [PubMed]

Medalla M, Barbas H. (2010). Anterior cingulate synapses in prefrontal areas 10 and 46 suggest differential influence in cognitive control. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Medalla M, Gilman JP, Wang JY, Luebke JI. (2017). Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Medalla M, Luebke JI. (2015). Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Mi Y, Katkov M, Tsodyks M. (2017). Synaptic Correlates of Working Memory Capacity. Neuron. 93 [PubMed]

Miller EK, Lundqvist M, Bastos AM. (2018). Working Memory 2.0. Neuron. 100 [PubMed]

Mongillo G, Barak O, Tsodyks M. (2008). Synaptic theory of working memory. Science (New York, N.Y.). 319 [PubMed]

Moore TL et al. (2017). Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. GeroScience. 39 [PubMed]

Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. (2003). Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiology of aging. 24 [PubMed]

Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. (2006). Executive system dysfunction occurs as early as middle-age in the rhesus monkey. Neurobiology of aging. 27 [PubMed]

Moore TL et al. (2005). Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behavioural brain research. 160 [PubMed]

Morrison JH, Baxter MG. (2012). The ageing cortical synapse: hallmarks and implications for cognitive decline. Nature reviews. Neuroscience. 13 [PubMed]

Motley SE et al. (2018). Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Nakamura A, Osonoi T, Terauchi Y. (2010). Relationship between urinary sodium excretion and pioglitazone-induced edema. Journal of diabetes investigation. 1 [PubMed]

Norris CM, Halpain S, Foster TC. (1998). Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Norris CM, Halpain S, Foster TC. (1998). Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging. Journal of neurophysiology. 80 [PubMed]

Oemisch M, Westendorff S, Everling S, Womelsdorf T. (2015). Interareal Spike-Train Correlations of Anterior Cingulate and Dorsal Prefrontal Cortex during Attention Shifts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Oliveira AM, Bading H. (2011). Calcium signaling in cognition and aging-dependent cognitive decline. BioFactors (Oxford, England). 37 [PubMed]

Peters A. (2007). Golgi, Cajal, and the fine structure of the nervous system. Brain research reviews. 55 [PubMed]

Peters A. (2009). The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Frontiers in neuroanatomy. 3 [PubMed]

Peters A, Kemper T. (2012). A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey. Neurobiology of aging. 33 [PubMed]

Peters A, Sethares C, Luebke JI. (2008). Synapses are lost during aging in the primate prefrontal cortex. Neuroscience. 152 [PubMed]

Povysheva NV, Zaitsev AV, Gonzalez-Burgos G, Lewis DA. (2013). Electrophysiological heterogeneity of fast-spiking interneurons: chandelier versus basket cells. PloS one. 8 [PubMed]

Proskovec AL, Heinrichs-Graham E, Wilson TW. (2016). Aging modulates the oscillatory dynamics underlying successful working memory encoding and maintenance. Human brain mapping. 37 [PubMed]

RStudio Team . (2015). RStudio: Integrated Development for R .

Rhodes MG. (2004). Age-related differences in performance on the Wisconsin card sorting test: a meta-analytic review. Psychology and aging. 19 [PubMed]

Rigotti M, Ben Dayan Rubin D, Wang XJ, Fusi S. (2010). Internal representation of task rules by recurrent dynamics: the importance of the diversity of neural responses. Frontiers in computational neuroscience. 4 [PubMed]

Rolls ET, Deco G. (2015). Stochastic cortical neurodynamics underlying the memory and cognitive changes in aging. Neurobiology of learning and memory. 118 [PubMed]

Rolls ET, Dempere-Marco L, Deco G. (2013). Holding multiple items in short term memory: a neural mechanism. PloS one. 8 [PubMed]

Rosenzweig ES, Barnes CA. (2003). Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Progress in neurobiology. 69 [PubMed]

Roxin A, Compte A. (2016). Oscillations in the bistable regime of neuronal networks. Physical review. E. 94 [PubMed]

Rumbell TH et al. (2016). Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. Journal of computational neuroscience. 41 [PubMed]

Salin PA, Prince DA. (1996). Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex. Journal of neurophysiology. 75 [PubMed]

Salinas E. (2004). Fast remapping of sensory stimuli onto motor actions on the basis of contextual modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Salthouse TA, Atkinson TM, Berish DE. (2003). Executive functioning as a potential mediator of age-related cognitive decline in normal adults. Journal of experimental psychology. General. 132 [PubMed]

Sandberg A, Tegnér J, Lansner A. (2003). A working memory model based on fast Hebbian learning. Network (Bristol, England). 14 [PubMed]

Shobin E et al. (2017). Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. GeroScience. 39 [PubMed]

Sorel O, Pennequin V. (2008). Aging of the planning process: the role of executive functioning. Brain and cognition. 66 [PubMed]

Spruston N, Jonas P, Sakmann B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. The Journal of physiology. 482 ( Pt 2) [PubMed]

Stein RB. (1967). Some models of neuronal variability. Biophysical journal. 7 [PubMed]

Teeter C et al. (2018). Generalized leaky integrate-and-fire models classify multiple neuron types. Nature communications. 9 [PubMed]

Thibault O et al. (2013). Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. European journal of pharmacology. 719 [PubMed]

Thibault O, Gant JC, Landfield PW. (2007). Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging cell. 6 [PubMed]

Toescu EC, Vreugdenhil M. (2010). Calcium and normal brain ageing. Cell calcium. 47 [PubMed]

Tsunada J, Cohen Y, Gold JI. (2019). Post-decision processing in primate prefrontal cortex influences subsequent choices on an auditory decision-making task. eLife. 8 [PubMed]

Wang M et al. (2019). A novel dopamine D1 receptor agonist excites delay-dependent working memory-related neuronal firing in primate dorsolateral prefrontal cortex. Neuropharmacology. 150 [PubMed]

Wang M et al. (2011). Neuronal basis of age-related working memory decline. Nature. 476 [PubMed]

Wang M et al. (2013). NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron. 77 [PubMed]

Wang Y et al. (2006). Heterogeneity in the pyramidal network of the medial prefrontal cortex. Nature neuroscience. 9 [PubMed]

Wei Z, Wang XJ, Wang DH. (2012). From distributed resources to limited slots in multiple-item working memory: a spiking network model with normalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Wimmer K, Nykamp DQ, Constantinidis C, Compte A. (2014). Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory. Nature neuroscience. 17 [PubMed]

Wu S, Wong KY, Fung CC, Mi Y, Zhang W. (2016). Continuous Attractor Neural Networks: Candidate of a Canonical Model for Neural Information Representation. F1000Research. 5 [PubMed]

Xiang Z, Huguenard JR, Prince DA. (1998). GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. The Journal of physiology. 506 ( Pt 3) [PubMed]

Ylvisaker D, Johnson ME, Moore LM. (1990). Minimax and maximin distance designs Journal of Statistical Planning and Inference. 26(2)

Young ME, Ohm DT, Dumitriu D, Rapp PR, Morrison JH. (2014). Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience. 274 [PubMed]

Zaitsev AV, Povysheva NV, Gonzalez-Burgos G, Lewis DA. (2012). Electrophysiological classes of layer 2/3 pyramidal cells in monkey prefrontal cortex. Journal of neurophysiology. 108 [PubMed]

Zaitsev AV et al. (2009). Interneuron diversity in layers 2-3 of monkey prefrontal cortex. Cerebral cortex (New York, N.Y. : 1991). 19 [PubMed]

References and models that cite this paper

Ibañez S, Sengupta N, Luebke JI, Wimmer K, Weaver CM. (2024). Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex. eLife. 12 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.