Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)


Wang J, Chen S, Nolan MF, Siegelbaum SA. (2002). Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron. 36 [PubMed]

See more from authors: Wang J · Chen S · Nolan MF · Siegelbaum SA

References and models cited by this paper

Altomare C et al. (2001). Integrated allosteric model of voltage gating of HCN channels. The Journal of general physiology. 117 [PubMed]

Bal T, von Krosigk M, McCormick DA. (1995). Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal of physiology. 483 ( Pt 3) [PubMed]

Bean BP. (1989). Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature. 340 [PubMed]

Bhalla US, Iyengar R. (1999). Emergent properties of networks of biological signaling pathways. Science (New York, N.Y.). 283 [PubMed]

Chen S, Wang J, Siegelbaum SA. (2001). Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. The Journal of general physiology. 117 [PubMed]

Colquhoun D, Hawkes AG. (1995). A Q-Matric cookbook: how to write only one program to calculate single-channel and macroscopic predictions for any kinetic mechanism. Single-channel Recording, Second Edition.

Cox DH, Cui J, Aldrich RW. (1997). Allosteric gating of a large conductance Ca-activated K+ channel. The Journal of general physiology. 110 [PubMed]

Cui J, Melman Y, Palma E, Fishman GI, McDonald TV. (2000). Cyclic AMP regulates the HERG K(+) channel by dual pathways. Current biology : CB. 10 [PubMed]

Davare MA et al. (2001). A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science (New York, N.Y.). 293 [PubMed]

Destexhe A, Bal T, McCormick DA, Sejnowski TJ. (1996). Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal of neurophysiology. 76 [PubMed]

DiFrancesco D. (1993). Pacemaker mechanisms in cardiac tissue. Annual review of physiology. 55 [PubMed]

DiFrancesco D. (1999). Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node. The Journal of physiology. 515 ( Pt 2) [PubMed]

DiFrancesco D, Tortora P. (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature. 351 [PubMed]

Gauss R, Seifert R, Kaupp UB. (1998). Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature. 393 [PubMed]

Goulding EH, Tibbs GR, Siegelbaum SA. (1994). Molecular mechanism of cyclic-nucleotide-gated channel activation. Nature. 372 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hines ML, Carnevale NT. (2000). Expanding NEURON's repertoire of mechanisms with NMODL. Neural computation. 12 [PubMed]

Karpen JW, Rich TC. (2001). The fourth dimension in cellular signaling. Science (New York, N.Y.). 293 [PubMed]

Kaupp UB, Seifert R. (2001). Molecular diversity of pacemaker ion channels. Annual review of physiology. 63 [PubMed]

Liu DT, Tibbs GR, Paoletti P, Siegelbaum SA. (1998). Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers. Neuron. 21 [PubMed]

Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. (1998). A family of hyperpolarization-activated mammalian cation channels. Nature. 393 [PubMed]

Lüthi A, McCormick DA. (1998). H-current: properties of a neuronal and network pacemaker. Neuron. 21 [PubMed]

Lüthi A, McCormick DA. (1998). Periodicity of thalamic synchronized oscillations: the role of Ca2+-mediated upregulation of Ih. Neuron. 20 [PubMed]

Lüthi A, McCormick DA. (1999). Modulation of a pacemaker current through Ca(2+)-induced stimulation of cAMP production. Nature neuroscience. 2 [PubMed]

MONOD J, WYMAN J, CHANGEUX JP. (1965). ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. Journal of molecular biology. 12 [PubMed]

Marx SO et al. (2002). Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (New York, N.Y.). 295 [PubMed]

McCormick DA, Huguenard JR. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. Journal of neurophysiology. 68 [PubMed]

Michel JJ, Scott JD. (2002). AKAP mediated signal transduction. Annual review of pharmacology and toxicology. 42 [PubMed]

Pape HC. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual review of physiology. 58 [PubMed]

Robison GA, Butcher RW, Sutherland EW. (1971). Cyclic Amp.

Ruiz ML, Karpen JW. (1997). Single cyclic nucleotide-gated channels locked in different ligand-bound states. Nature. 389 [PubMed]

Santoro B et al. (2000). Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Santoro B et al. (1998). Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 93 [PubMed]

Santoro B, Tibbs GR. (1999). The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels. Annals of the New York Academy of Sciences. 868 [PubMed]

Seifert R et al. (1999). Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proceedings of the National Academy of Sciences of the United States of America. 96 [PubMed]

Steriade M, McCormick DA, Sejnowski TJ. (1993). Thalamocortical oscillations in the sleeping and aroused brain. Science (New York, N.Y.). 262 [PubMed]

Tibbs GR, Goulding EH, Siegelbaum SA. (1997). Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels. Nature. 386 [PubMed]

Ulens C, Tytgat J. (2001). Functional heteromerization of HCN1 and HCN2 pacemaker channels. The Journal of biological chemistry. 276 [PubMed]

Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA, Tibbs GR. (2001). Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 411 [PubMed]

Wang J, Chen S, Siegelbaum SA. (2001). Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. The Journal of general physiology. 118 [PubMed]

Zaccolo M, Pozzan T. (2002). Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (New York, N.Y.). 295 [PubMed]

Zagotta WN, Siegelbaum SA. (1996). Structure and function of cyclic nucleotide-gated channels. Annual review of neuroscience. 19 [PubMed]

References and models that cite this paper

Angelo K, London M, Christensen SR, Häusser M. (2007). Local and global effects of I(h) distribution in dendrites of mammalian neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Bichler EK, Cavarretta F, Jaeger D. (2021). Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice. eNeuro. 8 [PubMed]

Carnevale NT, Hines M. (2003). Personal Communication of NEURON bibliography .

Chan CS et al. (2007). 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature. 447 [PubMed]

Chan CS, Shigemoto R, Mercer JN, Surmeier DJ. (2004). HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Day M et al. (2005). Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Elinder F, Männikkö R, Pandey S, Larsson HP. (2006). Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. The Journal of physiology. 575 [PubMed]

Gertler TS, Chan CS, Surmeier DJ. (2008). Dichotomous anatomical properties of adult striatal medium spiny neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Kopp-Scheinpflug C et al. (2011). The sound of silence: ionic mechanisms encoding sound termination. Neuron. 71 [PubMed]

Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. (2007). Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Männikkö R, Pandey S, Larsson HP, Elinder F. (2005). Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties. The Journal of general physiology. 125 [PubMed]

Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW. (2016). Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex. Frontiers in pharmacology. 7 [PubMed]

Neymotin SA et al. (2013). Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model. PloS one. 8 [PubMed]

Neymotin SA et al. (2016). Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex. Neuroscience. 316 [PubMed]

Schultheiss NW, Edgerton JR, Jaeger D. (2010). Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.