Cortex-Basal Ganglia-Thalamus network model (Kumaravelu et al. 2016)


Kumaravelu K, Brocker DT, Grill WM. (2016). A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease. Journal of computational neuroscience. 40 [PubMed]

See more from authors: Kumaravelu K · Brocker DT · Grill WM

References and models cited by this paper

Albin RL, Young AB, Penney JB. (1989). The functional anatomy of basal ganglia disorders. Trends in neurosciences. 12 [PubMed]

Anandhan A, Essa MM, Manivasagam T. (2013). Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease. Neurotoxicity research. 23 [PubMed]

Anderson ME, Postupna N, Ruffo M. (2003). Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey. Journal of neurophysiology. 89 [PubMed]

Baufreton J et al. (2009). Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus. Journal of neurophysiology. 102 [PubMed]

Bergman H, Wichmann T, Karmon B, DeLong MR. (1994). The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. Journal of neurophysiology. 72 [PubMed]

Birdno MJ, Grill WM. (2008). Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 5 [PubMed]

Blesa J, Przedborski S. (2014). Parkinson's disease: animal models and dopaminergic cell vulnerability. Frontiers in neuroanatomy. 8 [PubMed]

Bolam JP, Hanley JJ, Booth PA, Bevan MD. (2000). Synaptic organisation of the basal ganglia. Journal of anatomy. 196 ( Pt 4) [PubMed]

Bosch C, Degos B, Deniau JM, Venance L. (2011). Subthalamic nucleus high-frequency stimulation generates a concomitant synaptic excitation-inhibition in substantia nigra pars reticulata. The Journal of physiology. 589 [PubMed]

Brocker DT et al. (2013). Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. Experimental neurology. 239 [PubMed]

Brown DA. (2010). Muscarinic acetylcholine receptors (mAChRs) in the nervous system: some functions and mechanisms. Journal of molecular neuroscience : MN. 41 [PubMed]

Chang HT, Kitai ST. (1985). Projection neurons of the nucleus accumbens: an intracellular labeling study. Brain research. 347 [PubMed]

Chang HT, Wilson CJ, Kitai ST. (1982). A Golgi study of rat neostriatal neurons: light microscopic analysis. The Journal of comparative neurology. 208 [PubMed]

Cruz AV, Mallet N, Magill PJ, Brown P, Averbeck BB. (2011). Effects of dopamine depletion on information flow between the subthalamic nucleus and external globus pallidus. Journal of neurophysiology. 106 [PubMed]

DeLong MR. (1990). Primate models of movement disorders of basal ganglia origin. Trends in neurosciences. 13 [PubMed]

Degos B et al. (2005). Neuroleptic-induced catalepsy: electrophysiological mechanisms of functional recovery induced by high-frequency stimulation of the subthalamic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Dorval AD et al. (2008). Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease. Journal of neurophysiology. 100 [PubMed]

Farries MA, Kita H, Wilson CJ. (2010). Dynamic spike threshold and zero membrane slope conductance shape the response of subthalamic neurons to cortical input. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Fogelson N et al. (2005). Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease. Neuroscience letters. 382 [PubMed]

Fujimoto K, Kita H. (1993). Response characteristics of subthalamic neurons to the stimulation of the sensorimotor cortex in the rat. Brain research. 609 [PubMed]

Grill WM, Snyder AN, Miocinovic S. (2004). Deep brain stimulation creates an informational lesion of the stimulated nucleus. Neuroreport. 15 [PubMed]

Götz T et al. (1997). Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Hahn PJ, McIntyre CC. (2010). Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation. Journal of computational neuroscience. 28 [PubMed]

Hammond C, Bergman H, Brown P. (2007). Pathological synchronization in Parkinson's disease: networks, models and treatments. Trends in neurosciences. 30 [PubMed]

Hashimoto T, Elder CM, Okun MS, Patrick SK, Vitek JL. (2003). Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Hollerman JR, Grace AA. (1992). Subthalamic nucleus cell firing in the 6-OHDA-treated rat: basal activity and response to haloperidol. Brain research. 590 [PubMed]

Hornykiewicz O. (1998). Biochemical aspects of Parkinson's disease. Neurology. 51 [PubMed]

Humphries MD, Gurney K. (2012). Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output. The European journal of neuroscience. 36 [PubMed]

Ikarashi Y, Takahashi A, Ishimaru H, Arai T, Maruyama Y. (1997). Regulation of dopamine D1 and D2 receptors on striatal acetylcholine release in rats. Brain research bulletin. 43 [PubMed]

Izhikevich EM. (2003). Simple model of spiking neurons. IEEE transactions on neural networks. 14 [PubMed]

Jankovic J, Rajput AH, McDermott MP, Perl DP. (2000). The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Archives of neurology. 57 [PubMed]

Kang G, Lowery MM. (2013). Interaction of oscillations, and their suppression via deep brain stimulation, in a model of the cortico-basal ganglia network. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 21 [PubMed]

Kita H. (2001). Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice preparations. Neuroscience. 105 [PubMed]

Kita H, Kita T. (2011). Cortical stimulation evokes abnormal responses in the dopamine-depleted rat basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Kita H, Kitai ST. (1991). Intracellular study of rat globus pallidus neurons: membrane properties and responses to neostriatal, subthalamic and nigral stimulation. Brain research. 564 [PubMed]

Kitai ST, Kita H, Nakanishi H. (1987). Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation. Brain Res. 437

Kühn AA et al. (2008). High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Levy R et al. (2002). Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. Brain : a journal of neurology. 125 [PubMed]

Li Q et al. (2012). Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex. Neuron. 76 [PubMed]

Mallet N, Ballion B, Le Moine C, Gonon F. (2006). Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Mallet N et al. (2008). Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Mallet N et al. (2008). Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Marsden C, Parkes J, Quinn N. (1982). Fluctuations of disability in Parkinson’s disease: clinical aspects Movement disorders. 198(1)

McCarthy MM et al. (2011). Striatal origin of the pathologic beta oscillations in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 108 [PubMed]

McConnell GC, So RQ, Hilliard JD, Lopomo P, Grill WM. (2012). Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Miguelez C et al. (2012). Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease. The Journal of physiology. 590 [PubMed]

Moran RJ et al. (2011). Alterations in brain connectivity underlying beta oscillations in Parkinsonism. PLoS computational biology. 7 [PubMed]

Moro E et al. (2010). Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 25 [PubMed]

Nakanishi H, Kita H, Kitai ST. (1991). Intracellular study of rat entopeduncular nucleus neurons in an in vitro slice preparation: response to subthalamic stimulation. Brain research. 549 [PubMed]

Nambu A et al. (2000). Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. Journal of neurophysiology. 84 [PubMed]

Nambu A, Tokuno H, Takada M. (2002). Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway. Neuroscience research. 43 [PubMed]

Nicola SM, Surmeier J, Malenka RC. (2000). Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annual review of neuroscience. 23 [PubMed]

Otsuka T, Abe T, Tsukagawa T, Song WJ. (2004). Conductance-based model of the voltage-dependent generation of a plateau potential in subthalamic neurons. Journal of neurophysiology. 92 [PubMed]

Pan MK et al. (2014). Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. The Journal of clinical investigation. 124 [PubMed]

Pang Z, Ling GY, Gajendiran M, Xu ZC. (2001). Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation. Neuroscience letters. 308 [PubMed]

Plenz D, Kital ST. (1999). A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature. 400 [PubMed]

Quinn NP, Luthert P, Honavar M, Marsden CD. (1989). Pure akinesia due to lewy body Parkinson's disease: a case with pathology. Movement disorders : official journal of the Movement Disorder Society. 4 [PubMed]

Rajput AH et al. (2008). Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation. Neurology. 70 [PubMed]

Raz A, Vaadia E, Bergman H. (2000). Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Rubin JE, Terman D. (2004). High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. Journal of computational neuroscience. 16 [PubMed]

Ryu SB et al. (2013). Neuronal Responses in the Globus Pallidus during Subthalamic Nucleus Electrical Stimulation in Normal and Parkinson's Disease Model Rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 17 [PubMed]

Shaw FZ, Liao YF. (2005). Relation between activities of the cortex and vibrissae muscles during high-voltage rhythmic spike discharges in rats. Journal of neurophysiology. 93 [PubMed]

Sims RE, Woodhall GL, Wilson CL, Stanford IM. (2008). Functional characterization of GABAergic pallidopallidal and striatopallidal synapses in the rat globus pallidus in vitro. The European journal of neuroscience. 28 [PubMed]

So RQ, Kent AR, Grill WM. (2012). Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study. Journal of computational neuroscience. 32 [PubMed]

So RQ, McConnell GC, August AT, Grill WM. (2012). Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 20 [PubMed]

Taverna S, Ilijic E, Surmeier DJ. (2008). Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Timmermann L et al. (2004). Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 19 [PubMed]

Tremblay L, Filion M, Bédard PJ. (1989). Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism. Brain research. 498 [PubMed]

Walker HC et al. (2012). Short latency activation of cortex by clinically effective thalamic brain stimulation for tremor. Movement disorders : official journal of the Movement Disorder Society. 27 [PubMed]

Weaver FM et al. (2009). Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 301 [PubMed]

Wichmann T, Soares J. (2006). Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism. Journal of neurophysiology. 95 [PubMed]

Xu W, Russo GS, Hashimoto T, Zhang J, Vitek JL. (2008). Subthalamic nucleus stimulation modulates thalamic neuronal activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Yamawaki N, Stanford IM, Hall SD, Woodhall GL. (2008). Pharmacologically induced and stimulus evoked rhythmic neuronal oscillatory activity in the primary motor cortex in vitro. Neuroscience. 151 [PubMed]

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