Dopamine neuron of the vent. periaqu. gray and dors. raphe nucleus (vlPAG/DRN) (Dougalis et al 2017)


Dougalis AG, Matthews GAC, Liss B, Ungless MA. (2017). Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study. Journal of computational neuroscience. 42 [PubMed]

See more from authors: Dougalis AG · Matthews GAC · Liss B · Ungless MA

References and models cited by this paper

Beier KT et al. (2015). Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Cell. 162 [PubMed]

Bishop MW et al. (2010). Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. Journal of neurophysiology. 104 [PubMed]

Branch SY, Sharma R, Beckstead MJ. (2014). Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Brevi S, de Curtis M, Magistretti J. (2001). Pharmacological and biophysical characterization of voltage-gated calcium currents in the endopiriform nucleus of the guinea pig. Journal of neurophysiology. 85 [PubMed]

Brown DA, Adams PR. (1980). Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. Nature. 283 [PubMed]

Brown DA, Passmore GM. (2009). Neural KCNQ (Kv7) channels. British journal of pharmacology. 156 [PubMed]

Budde T, Meuth S, Pape HC. (2002). Calcium-dependent inactivation of neuronal calcium channels. Nature reviews. Neuroscience. 3 [PubMed]

Catterall WA. (2000). Structure and regulation of voltage-gated Ca2+ channels. Annual review of cell and developmental biology. 16 [PubMed]

Chan CS et al. (2007). 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature. 447 [PubMed]

Deignan J et al. (2012). SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. 217 [PubMed]

Ding S, Wei W, Zhou FM. (2011). Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra. Journal of neurophysiology. 106 [PubMed]

Dougalis AG et al. (2012). Functional properties of dopamine neurons and co-expression of vasoactive intestinal polypeptide in the dorsal raphe nucleus and ventro-lateral periaqueductal grey. The European journal of neuroscience. 36 [PubMed]

Drion G et al. (2010). M-type channels selectively control bursting in rat dopaminergic neurons. The European journal of neuroscience. 31 [PubMed]

Drion G, Massotte L, Sepulchre R, Seutin V. (2011). How modeling can reconcile apparently discrepant experimental results: the case of pacemaking in dopaminergic neurons. PLoS computational biology. 7 [PubMed]

Edwards FA, Konnerth A, Sakmann B, Takahashi T. (1989). A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflugers Archiv : European journal of physiology. 414 [PubMed]

Flores JA, El Banoua F, Galán-Rodríguez B, Fernandez-Espejo E. (2004). Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors. Pain. 110 [PubMed]

Flores JA, Galan-Rodriguez B, Ramiro-Fuentes S, Fernandez-Espejo E. (2006). Role for dopamine neurons of the rostral linear nucleus and periaqueductal gray in the rewarding and sensitizing properties of heroin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 31 [PubMed]

Giannattasio B, Jones SW, Scarpa A. (1991). Calcium currents in the A7r5 smooth muscle-derived cell line. Calcium-dependent and voltage-dependent inactivation. The Journal of general physiology. 98 [PubMed]

Grace AA, Bunney BS. (1983). Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--2. Action potential generating mechanisms and morphological correlates. Neuroscience. 10 [PubMed]

Grace AA, Bunney BS. (1983). Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--1. Identification and characterization. Neuroscience. 10 [PubMed]

Grace AA, Bunney BS. (1984). The control of firing pattern in nigral dopamine neurons: burst firing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 4 [PubMed]

Grace AA, Bunney BS. (1984). The control of firing pattern in nigral dopamine neurons: single spike firing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 4 [PubMed]

Grace AA, Bunney BS, Moore H, Todd CL. (1997). Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends in neurosciences. 20 [PubMed]

Grace AA, Onn SP. (1989). Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. 9 [PubMed]

Guzman JN et al. (2010). Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 468 [PubMed]

Guzman JN, Sánchez-Padilla J, Chan CS, Surmeier DJ. (2009). Robust pacemaking in substantia nigra dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Haack JA, Rosenberg RL. (1994). Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers. Biophysical journal. 66 [PubMed]

Hadley JK et al. (2000). Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. British journal of pharmacology. 129 [PubMed]

Hansen HH et al. (2006). The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. The Journal of pharmacology and experimental therapeutics. 318 [PubMed]

Hille B. (2001). Ionic Channels of Excitable Membranes.

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hokfelt T, Goldstein M, Bjorklund A, Martensson R, Kleinau S. (1984). Distribution of tyrosine-hydroxylaseimmunoreactive neurons in the rat brain Handbook of chemical neuroanatomy.

Itri JN, Michel S, Vansteensel MJ, Meijer JH, Colwell CS. (2005). Fast delayed rectifier potassium current is required for circadian neural activity. Nature neuroscience. 8 [PubMed]

Jackson AC, Yao GL, Bean BP. (2004). Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Kang Y, Kitai ST. (1993). A whole cell patch-clamp study on the pacemaker potential in dopaminergic neurons of rat substantia nigra compacta. Neuroscience research. 18 [PubMed]

Kang Y, Kitai ST. (1993). Calcium spike underlying rhythmic firing in dopaminergic neurons of the rat substantia nigra. Neuroscience research. 18 [PubMed]

Keja JA, Stoof JC, Kits KS. (1992). Dopamine D2 receptor stimulation differentially affects voltage-activated calcium channels in rat pituitary melanotropic cells. The Journal of physiology. 450 [PubMed]

Khaliq ZM, Bean BP. (2008). Dynamic, nonlinear feedback regulation of slow pacemaking by A-type potassium current in ventral tegmental area neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Khaliq ZM, Bean BP. (2010). Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Kimm T, Bean BP. (2014). Inhibition of A-type potassium current by the peptide toxin SNX-482. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Kimm T, Khaliq ZM, Bean BP. (2015). Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Koyama S, Appel SB. (2006). A-type K+ current of dopamine and GABA neurons in the ventral tegmental area. Journal of neurophysiology. 96 [PubMed]

Koyama S, Appel SB. (2006). Characterization of M-current in ventral tegmental area dopamine neurons. Journal of neurophysiology. 96 [PubMed]

Koyama S, Brodie MS, Appel SB. (2007). Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons. Journal of neurophysiology. 97 [PubMed]

Koyama S, Kanemitsu Y, Weight FF. (2005). Spontaneous activity and properties of two types of principal neurons from the ventral tegmental area of rat. Journal of neurophysiology. 93 [PubMed]

Lacey MG, Mercuri NB, North RA. (1989). Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. The Journal of neuroscience : the official journal of the Society for Neuroscience. 9 [PubMed]

Lammel S et al. (2008). Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron. 57 [PubMed]

Lammel S, Ion DI, Roeper J, Malenka RC. (2011). Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron. 70 [PubMed]

Lerner TN et al. (2015). Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits. Cell. 162 [PubMed]

Li C, McCall NM, Lopez AJ, Kash TL. (2013). Alcohol effects on synaptic transmission in periaqueductal gray dopamine neurons. Alcohol (Fayetteville, N.Y.). 47 [PubMed]

Li C et al. (2016). Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41 [PubMed]

Liss B et al. (2001). Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. The EMBO journal. 20 [PubMed]

Lu J, Jhou TC, Saper CB. (2006). Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Magistretti J, Castelli L, Forti L, D'Angelo E. (2006). Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: an electrophysiological and modelling study. The Journal of physiology. 573 [PubMed]

Malin SA, Nerbonne JM. (2002). Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Margolis EB, Lock H, Hjelmstad GO, Fields HL. (2006). The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? The Journal of physiology. 577 [PubMed]

Matthews GA et al. (2016). Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation. Cell. 164 [PubMed]

Mercuri NB et al. (1994). Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones. British journal of pharmacology. 113 [PubMed]

Milescu LS, Bean BP, Smith JC. (2010). Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Mosharov EV et al. (2009). Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 62 [PubMed]

Nedergaard S, Flatman JA, Engberg I. (1993). Nifedipine- and omega-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neurones. The Journal of physiology. 466 [PubMed]

Neuhoff H, Neu A, Liss B, Roeper J. (2002). I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Philippart F et al. (2016). Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]

Pignatelli A, Kobayashi K, Okano H, Belluzzi O. (2005). Functional properties of dopaminergic neurones in the mouse olfactory bulb. The Journal of physiology. 564 [PubMed]

Poetschke C et al. (2015). Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports. 5 [PubMed]

Pollack AE. (2001). Anatomy, physiology, and pharmacology of the basal ganglia. Neurologic clinics. 19 [PubMed]

Poulin JF et al. (2014). Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling. Cell reports. 9 [PubMed]

Puopolo M, Raviola E, Bean BP. (2007). Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Putzier I, Kullmann PH, Horn JP, Levitan ES. (2009). Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Schultz W. (1998). Predictive reward signal of dopamine neurons. Journal of neurophysiology. 80 [PubMed]

Seutin V, Massotte L, Renette MF, Dresse A. (2001). Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons. Neuroreport. 12 [PubMed]

Shah MM, Migliore M, Brown DA. (2011). Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. The Journal of physiology. 589 [PubMed]

Silva NL, Pechura CM, Barker JL. (1990). Postnatal rat nigrostriatal dopaminergic neurons exhibit five types of potassium conductances. Journal of neurophysiology. 64 [PubMed]

Stuart GJ, Dodt HU, Sakmann B. (1993). Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Archiv : European journal of physiology. 423 [PubMed]

Subramaniam M et al. (2014). Mutant a-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Surmeier DJ, Guzman JN, Sanchez-Padilla J, Schumacker PT. (2011). The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease. Neuroscience. 198 [PubMed]

Surmeier DJ, Schumacker PT. (2013). Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease. The Journal of biological chemistry. 288 [PubMed]

Tucker KR, Huertas MA, Horn JP, Canavier CC, Levitan ES. (2012). Pacemaker rate and depolarization block in nigral dopamine neurons: a somatic sodium channel balancing act. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Wilson CJ, Callaway JC. (2000). Coupled oscillator model of the dopaminergic neuron of the substantia nigra. Journal of neurophysiology. 83 [PubMed]

Wladyka CL, Kunze DL. (2006). KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons. The Journal of physiology. 575 [PubMed]

Wolfart J, Neuhoff H, Franz O, Roeper J. (2001). Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Wolfart J, Roeper J. (2002). Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Xiao J et al. (2004). Voltage-clamp analysis and computational model of dopaminergic neurons from mouse retina. Visual neuroscience. 21 [PubMed]

Zhao S et al. (2004). Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. The European journal of neuroscience. 19 [PubMed]

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