Markovian model for cardiac sodium channel (Clancy, Rudy 2002)

Abriel H et al. (2001). Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circulation research. 88 [PubMed]

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Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Dumaine R et al. (1999). Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circulation research. 85 [PubMed]

Dumaine R et al. (1996). Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation research. 78 [PubMed]

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• Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP) [Model]
• Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Liu DW, Gintant GA, Antzelevitch C. (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circulation research. 72 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Miyazaki T et al. (1996). Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. Journal of the American College of Cardiology. 27 [PubMed]

Rook MB et al. (2004). A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res. 85

Rudy Y. (2000). The electrocardiogram and cardiac excitation Heart Physiology and Pathophysiology.

Veldkamp MW et al. (2000). Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel. Circulation research. 86 [PubMed]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

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Yan GX, Antzelevitch C. (1999). Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 100 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

• Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004) [Model]

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]

• HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011) [Model]

Kahlig KM, Misra SN, George AL. (2006). Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]