Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)


Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS. (2016). Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]

See more from authors: Buchin A · Chizhov A · Huberfeld G · Miles R · Gutkin BS

References and models cited by this paper

Alger BE, Nicoll RA. (1982). Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro. The Journal of physiology. 328 [PubMed]

Antonio LL et al. (2016). In vitro seizure like events and changes in ionic concentration. Journal of neuroscience methods. 260 [PubMed]

Barreto E, Cressman JR. (2011). Ion concentration dynamics as a mechanism for neuronal bursting. Journal of biological physics. 37 [PubMed]

Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ. (2004). Potassium model for slow (2-3 Hz) in vivo neocortical paroxysmal oscillations. Journal of neurophysiology. 92 [PubMed]

Ben-Ari Y. (2002). Excitatory actions of gaba during development: the nature of the nurture. Nature reviews. Neuroscience. 3 [PubMed]

Brunel N, Wang XJ. (2001). Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. Journal of computational neuroscience. 11 [PubMed]

Buzsáki G, Anastassiou CA, Koch C. (2012). The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes. Nature reviews. Neuroscience. 13 [PubMed]

Bédard C, Destexhe A. (2009). Macroscopic models of local field potentials and the apparent 1/f noise in brain activity. Biophysical journal. 96 [PubMed]

Böhm C et al. (2015). Functional Diversity of Subicular Principal Cells during Hippocampal Ripples. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Chang H, Fujita T. (1999). A numerical model of the renal distal tubule. The American journal of physiology. 276 [PubMed]

Chizhov AV. (2002). [A model for evoked activity of hippocampal neuronal population]. Biofizika. 47 [PubMed]

Chizhov AV, Sanchez-Aguilera A, Rodrigues S, de la Prida LM. (2015). Simplest relationship between local field potential and intracellular signals in layered neural tissue. Physical review. E, Statistical, nonlinear, and soft matter physics. 92 [PubMed]

Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. (2002). On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science (New York, N.Y.). 298 [PubMed]

Colling SB, Stanford IM, Traub RD, Jefferys JG. (1998). Limbic gamma rhythms. I. Phase-locked oscillations in hippocampal CA1 and subiculum. Journal of neurophysiology. 80 [PubMed]

Cressman JR, Ullah G, Ziburkus J, Schiff SJ, Barreto E. (2009). The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. Journal of computational neuroscience. 26 [PubMed]

D'Antuono M et al. (2004). GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex. Brain : a journal of neurology. 127 [PubMed]

Deisz RA, Lehmann TN, Horn P, Dehnicke C, Nitsch R. (2011). Components of neuronal chloride transport in rat and human neocortex. The Journal of physiology. 589 [PubMed]

Deisz RA, Wierschke S, Schneider UC, Dehnicke C. (2014). Effects of VU0240551, a novel KCC2 antagonist, and DIDS on chloride homeostasis of neocortical neurons from rats and humans. Neuroscience. 277 [PubMed]

Demont-Guignard S et al. (2012). Distinct hyperexcitability mechanisms underlie fast ripples and epileptic spikes. Annals of neurology. 71 [PubMed]

Dietzel I, Heinemann U. (1986). Dynamic variations of the brain cell microenvironment in relation to neuronal hyperactivity. Annals of the New York Academy of Sciences. 481 [PubMed]

Dietzel I, Heinemann U, Lux HD. (1989). Relations between slow extracellular potential changes, glial potassium buffering, and electrolyte and cellular volume changes during neuronal hyperactivity in cat brain. Glia. 2 [PubMed]

Doyon N et al. (2011). Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS computational biology. 7 [PubMed]

Doyon N, Vinay L, Prescott SA, De Koninck Y. (2016). Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition. Neuron. 89 [PubMed]

Dulla CG et al. (2005). Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron. 48 [PubMed]

Fertziger AP, Ranck JB. (1970). Potassium accumulation in interstitial space during epileptiform seizures. Experimental neurology. 26 [PubMed]

Fisher RS, Pedley TA, Prince DA. (1976). Kinetics of potassium movement in norman cortex. Brain research. 101 [PubMed]

Fisher RS et al. (2005). Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 46 [PubMed]

Florence G, Dahlem MA, Almeida AC, Bassani JW, Kurths J. (2009). The role of extracellular potassium dynamics in the different stages of ictal bursting and spreading depression: a computational study. Journal of theoretical biology. 258 [PubMed]

Fröhlich F, Bazhenov M, Iragui-Madoz V, Sejnowski TJ. (2008). Potassium dynamics in the epileptic cortex: new insights on an old topic. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 14 [PubMed]

Fröhlich F, Bazhenov M, Sejnowski TJ. (2008). Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M. (2007). Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity. The European journal of neuroscience. 25 [PubMed]

Fujiwara-Tsukamoto Y et al. (2010). Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

GRAFSTEIN B. (1956). Mechanism of spreading cortical depression. Journal of neurophysiology. 19 [PubMed]

Gagnon M et al. (2013). Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nature medicine. 19 [PubMed]

Glykys J et al. (2014). Local impermeant anions establish the neuronal chloride concentration. Science (New York, N.Y.). 343 [PubMed]

Gnatkovsky V, Librizzi L, Trombin F, de Curtis M. (2008). Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro. Annals of neurology. 64 [PubMed]

Grisar T. (1984). Glial and neuronal Na+-K+ pump in epilepsy. Annals of neurology. 16 Suppl [PubMed]

Hamidi S, Avoli M. (2015). KCC2 function modulates in vitro ictogenesis. Neurobiology of disease. 79 [PubMed]

Hekmat-Scafe DS, Lundy MY, Ranga R, Tanouye MA. (2006). Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Hentschke M et al. (2006). Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold. Molecular and cellular biology. 26 [PubMed]

Huberfeld G et al. (2011). Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy. Nature neuroscience. 14 [PubMed]

Huberfeld G et al. (2007). Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Huchzermeyer C et al. (2008). Gamma oscillations and spontaneous network activity in the hippocampus are highly sensitive to decreases in pO2 and concomitant changes in mitochondrial redox state. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hübel N, Dahlem MA. (2014). Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs. PLoS computational biology. 10 [PubMed]

Hübner CA et al. (2001). Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron. 30 [PubMed]

Isomura Y et al. (2003). Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons. Journal of neurophysiology. 90 [PubMed]

Jackson J, Goutagny R, Williams S. (2011). Fast and slow ? rhythms are intrinsically and independently generated in the subiculum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Jedlicka P, Deller T, Gutkin BS, Backus KH. (2011). Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission. Hippocampus. 21 [PubMed]

Jensen MS, Azouz R, Yaari Y. (1994). Variant firing patterns in rat hippocampal pyramidal cells modulated by extracellular potassium. Journal of neurophysiology. 71 [PubMed]

Jirsa VK, Stacey WC, Quilichini PP, Ivanov AI, Bernard C. (2014). On the nature of seizure dynamics. Brain : a journal of neurology. 137 [PubMed]

Jung HY, Staff NP, Spruston N. (2001). Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Kager H, Wadman WJ, Somjen GG. (2000). Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. Journal of neurophysiology. 84 [PubMed]

Kager H, Wadman WJ, Somjen GG. (2007). Seizure-like afterdischarges simulated in a model neuron. Journal of computational neuroscience. 22 [PubMed]

Kaila K, Voipio J. (1987). Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature. 330 [PubMed]

Khalilov I, Dzhala V, Ben-Ari Y, Khazipov R. (1999). Dual role of GABA in the neonatal rat hippocampus. Developmental neuroscience. 21 [PubMed]

Kraig RP, Nicholson C. (1978). Extracellular ionic variations during spreading depression. Neuroscience. 3 [PubMed]

Krishnan GP, Bazhenov M. (2011). Ionic dynamics mediate spontaneous termination of seizures and postictal depression state. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

LeBeau FE, Towers SK, Traub RD, Whittington MA, Buhl EH. (2002). Fast network oscillations induced by potassium transients in the rat hippocampus in vitro. The Journal of physiology. 542 [PubMed]

Lewin N, Aksay E, Clancy CE. (2012). Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PloS one. 7 [PubMed]

Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. (2012). Pyramidal cells accumulate chloride at seizure onset. Neurobiology of disease. 47 [PubMed]

Lytton WW. (2008). Computer modelling of epilepsy. Nature reviews. Neuroscience. 9 [PubMed]

Mainen ZF, Sejnowski TJ. (1996). Influence of dendritic structure on firing pattern in model neocortical neurons. Nature. 382 [PubMed]

Marder E, Taylor AL. (2011). Multiple models to capture the variability in biological neurons and networks. Nature neuroscience. 14 [PubMed]

Naze S, Bernard C, Jirsa V. (2015). Computational modeling of seizure dynamics using coupled neuronal networks: factors shaping epileptiform activity. PLoS computational biology. 11 [PubMed]

Pallud J et al. (2014). Cortical GABAergic excitation contributes to epileptic activities around human glioma. Science translational medicine. 6 [PubMed]

Payne JA. (1997). Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. The American journal of physiology. 273 [PubMed]

Payne JA, Rivera C, Voipio J, Kaila K. (2003). Cation-chloride co-transporters in neuronal communication, development and trauma. Trends in neurosciences. 26 [PubMed]

Proix T, Bartolomei F, Chauvel P, Bernard C, Jirsa VK. (2014). Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Renart A, Moreno-Bote R, Wang XJ, Parga N. (2007). Mean-driven and fluctuation-driven persistent activity in recurrent networks. Neural computation. 19 [PubMed]

Rivera C et al. (1999). The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature. 397 [PubMed]

Schevon CA et al. (2012). Evidence of an inhibitory restraint of seizure activity in humans. Nature communications. 3 [PubMed]

Schiff SJ, Ullah G. (2009). Models of epilepsy Scholarpedia. 4

Schuchmann S, Vanhatalo S, Kaila K. (2009). Neurobiological and physiological mechanisms of fever-related epileptiform syndromes. Brain & development. 31 [PubMed]

Shinnar S et al. (2005). Comment on epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE), author reply 1701-1702 Epilepsia. 46

Sivakumaran S et al. (2015). Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Staff NP, Jung HY, Thiagarajan T, Yao M, Spruston N. (2000). Resting and active properties of pyramidal neurons in subiculum and CA1 of rat hippocampus. Journal of neurophysiology. 84 [PubMed]

Staley KJ, Proctor WR. (1999). Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. The Journal of physiology. 519 Pt 3 [PubMed]

Staley KJ, Soldo BL, Proctor WR. (1995). Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science (New York, N.Y.). 269 [PubMed]

Stanford IM, Traub RD, Jefferys JG. (1998). Limbic gamma rhythms. II. Synaptic and intrinsic mechanisms underlying spike doublets in oscillating subicular neurons. Journal of neurophysiology. 80 [PubMed]

Talos DM et al. (2012). Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. Annals of neurology. 71 [PubMed]

Tolner EA et al. (2011). Five percent CO2 is a potent, fast-acting inhalation anticonvulsant. Epilepsia. 52 [PubMed]

Traub RD, Miles R, Wong RK, Schulman LS, Schneiderman JH. (1987). Models of synchronized hippocampal bursts in the presence of inhibition. II. Ongoing spontaneous population events. Journal of neurophysiology. 58 [PubMed]

Trevelyan AJ, Sussillo D, Yuste R. (2007). Feedforward inhibition contributes to the control of epileptiform propagation speed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Ullah G, Cressman JR, Barreto E, Schiff SJ. (2009). The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics. Journal of computational neuroscience. 26 [PubMed]

Viitanen T, Ruusuvuori E, Kaila K, Voipio J. (2010). The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. The Journal of physiology. 588 [PubMed]

Volman V, Ben-Jacob E, Levine H. (2007). The astrocyte as a gatekeeper of synaptic information transfer. Neural computation. 19 [PubMed]

Wallraff A et al. (2006). The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Wei Y, Ullah G, Schiff SJ. (2014). Unification of neuronal spikes, seizures, and spreading depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Wendling F, Bartolomei F, Mina F, Huneau C, Benquet P. (2012). Interictal spikes, fast ripples and seizures in partial epilepsies--combining multi-level computational models with experimental data. The European journal of neuroscience. 36 [PubMed]

Whittington MA, Traub RD, Kopell N, Ermentrout B, Buhl EH. (2000). Inhibition-based rhythms: experimental and mathematical observations on network dynamics. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 38 [PubMed]

Woo NS et al. (2002). Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 12 [PubMed]

Zhang ZJ, Valiante TA, Carlen PL. (2011). Transition to seizure: from "macro"- to "micro"-mysteries. Epilepsy research. 97 [PubMed]

de la Prida LM, Huberfeld G, Cohen I, Miles R. (2006). Threshold behavior in the initiation of hippocampal population bursts. Neuron. 49 [PubMed]

References and models that cite this paper

Chizhov AV, Zefirov AV, Amakhin DV, Smirnova EY, Zaitsev AV. (2018). Minimal model of interictal and ictal discharges "Epileptor-2". PLoS computational biology. 14 [PubMed]

Kolbaev SN et al. (2020). NKCC-1 mediated Cl- uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs. Scientific reports. 10 [PubMed]

Liou JY et al. (2020). A model for focal seizure onset, propagation, evolution, and progression. eLife. 9 [PubMed]

Lombardi A, Jedlicka P, Luhmann HJ, Kilb W. (2019). Interactions Between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl-Transport Shape Activity-Dependent Changes of Intracellular Cl- Concentration International journal of molecular sciences. 20 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.