Cerebellar Nucleus Neuron (Steuber, Schultheiss, Silver, De Schutter & Jaeger, 2010)


Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

See more from authors: Steuber V · Schultheiss NW · Silver RA · De Schutter E · Jaeger D

References and models cited by this paper

Achard P, De Schutter E. (2006). Complex parameter landscape for a complex neuron model. PLoS computational biology. 2 [PubMed]

Aizenman CD, Linden DJ. (1999). Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. Journal of neurophysiology. 82 [PubMed]

Aizenman CD, Linden DJ. (2000). Rapid, synaptically driven increases in the intrinsic excitability of cerebellar deep nuclear neurons. Nature neuroscience. 3 [PubMed]

Alviña K, Khodakhah K. (2008). Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats. The Journal of physiology. 586 [PubMed]

Alviña K, Walter JT, Kohn A, Ellis-Davies G, Khodakhah K. (2008). Questioning the role of rebound firing in the cerebellum. Nature neuroscience. 11 [PubMed]

Alzheimer C, Schwindt PC, Crill WE. (1993). Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Anchisi D, Scelfo B, Tempia F. (2001). Postsynaptic currents in deep cerebellar nuclei. Journal of neurophysiology. 85 [PubMed]

Aracri P et al. (2006). Layer-specific properties of the persistent sodium current in sensorimotor cortex. Journal of neurophysiology. 95 [PubMed]

Banke TG, McBain CJ. (2006). GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ. (2003). Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature neuroscience. 6 [PubMed]

Baranauskas G, Tkatch T, Surmeier DJ. (1999). Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Bower JM. (1997). Is the cerebellum sensory for motor's sake, or motor for sensory's sake: the view from the whiskers of a rat? Progress in brain research. 114 [PubMed]

Bower JM, Beeman D. (1995). The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System..

Brown AM, Schwindt PC, Crill WE. (1994). Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels. Journal of neurophysiology. 71 [PubMed]

Cavdar S, San T, Aker R, Sehirli U, Onat F. (2001). Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat. Journal of anatomy. 198 [PubMed]

Choi JS, Moore JW. (2003). Cerebellar neuronal activity expresses the complex topography of conditioned eyeblink responses. Behavioral neuroscience. 117 [PubMed]

Daniel H, Billard JM, Angaut P, Batini C. (1987). The interposito-rubrospinal system. Anatomical tracing of a motor control pathway in the rat. Neuroscience research. 5 [PubMed]

De Schutter E, Bower JM. (1994). An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. Journal of neurophysiology. 71 [PubMed]

De Schutter E, Jaeger D, Steuber V. (2004). Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors Neurocomputing. 58-60

Destexhe A, Neubig M, Ulrich D, Huguenard J. (1998). Dendritic low-threshold calcium currents in thalamic relay cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Fredette BJ, Mugnaini E. (1991). The GABAergic cerebello-olivary projection in the rat. Anatomy and embryology. 184 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. I. Postsynaptic potentials. Brain research. 351 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. II. Membrane conductances. Brain research. 352 [PubMed]

Gardner EP, Fuchs AF. (1975). Single-unit responses to natural vestibular stimuli and eye movements in deep cerebellar nuclei of the alert rhesus monkey. Journal of neurophysiology. 38 [PubMed]

Gauck V, Jaeger D. (2000). The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Gauck V, Jaeger D. (2003). The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Gauck V, Thomann M, Jaeger D, Borst A. (2001). Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Gibson AR, Horn KM, Stein JF, Van Kan PL. (1996). Activity of interpositus neurons during a visually guided reach. Canadian journal of physiology and pharmacology. 74 [PubMed]

Gleeson P et al. (2010). NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS computational biology. 6 [PubMed]

Goodkin HP, Thach WT. (2003). Cerebellar control of constrained and unconstrained movements. II. EMG and nuclear activity. Journal of neurophysiology. 89 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hartline DK, Castelfranco AM. (2002). Simulations of space-clamp errors in estimating parameters of voltage-gated conductances localized at different electrotonic distances Neurocomputing. 44

Hepp K, Henn V, Jaeger J. (1982). Eye movement related neurons in the cerebellar nuclei of the alert monkey. Experimental brain research. 45 [PubMed]

Hille B. (2001). Ionic Channels of Excitable Membranes.

Houk JC, Buckingham JT, Barto AG. (1996). Models of the cerebellum and motor learning. Behav Brain Sci. 19

Ito M. (2008). Control of mental activities by internal models in the cerebellum. Nature reviews. Neuroscience. 9 [PubMed]

Ivry R, Keele S. (1989). Timing function of the cerebellum J Cognit Neurosci. 1

Jaeger D. (2003). No Parallel Fiber Volleys in the Cerebellar Cortex: Evidence from Cross-Correlation Analysis between Purkinje Cells in a Computer Model and in Recordings from Anesthetized Rats Journal of computational neuroscience. 14 [PubMed]

Jaeger D, Bower JM. (1999). Synaptic control of spiking in cerebellar Purkinje cells: dynamic current clamp based on model conductances. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Jaeger D, Sangrey TD. (2005). Currents underlying hyperpolarization-induced rebound spiking in deep cerebellar nuclei neurons Society for Neuroscience Abstract 179.10.

Jagodic MM et al. (2007). Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Jahnsen H. (1986). Electrophysiological characteristics of neurones in the guinea-pig deep cerebellar nuclei in vitro. The Journal of physiology. 372 [PubMed]

Jahnsen H. (1986). Extracellular activation and membrane conductances of neurones in the guinea-pig deep cerebellar nuclei in vitro. The Journal of physiology. 372 [PubMed]

Kleine JF, Guan Y, Buttner U. (2003). Saccade-related neurons in the primate fastigial nucleus: what do they encode? Journal of neurophysiology. 90 [PubMed]

Lang EJ, Sugihara I, Welsh JP, Llinás R. (1999). Patterns of spontaneous purkinje cell complex spike activity in the awake rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Lee HH et al. (2007). Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. The Journal of biological chemistry. 282 [PubMed]

Llinás R, Mühlethaler M. (1988). Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. The Journal of physiology. 404 [PubMed]

MacKay WA. (1988). Cerebellar nuclear activity in relation to simple movements. Experimental brain research. 71 [PubMed]

Magistretti J, Alonso A. (1999). Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study. The Journal of general physiology. 114 [PubMed]

Medina JF, Garcia KS, Nores WL, Taylor NM, Mauk MD. (2000). Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Molineux ML et al. (2006). Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Muri R, Knöpfel T. (1994). Activity induced elevations of intracellular calcium concentration in neurons of the deep cerebellar nuclei. Journal of neurophysiology. 71 [PubMed]

Otsuka T, Abe T, Tsukagawa T, Song WJ. (2004). Conductance-based model of the voltage-dependent generation of a plateau potential in subthalamic neurons. Journal of neurophysiology. 92 [PubMed]

Palkovits M, Mezey E, Hámori J, Szentágothai J. (1977). Quantitative histological analysis of the cerebellar nuclei in the cat. I. Numerical data on cells and on synapses. Experimental brain research. 28 [PubMed]

Pape HC. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual review of physiology. 58 [PubMed]

Paulin MG. (1995). System identification of spiking sensory neurons using realistically constrained nonlinear time series models. Advances in processing and pattern analysis of biological signals.

Pedroarena CM. (2010). Mechanisms supporting transfer of inhibitory signals into the spike output of spontaneously firing cerebellar nuclear neurons in vitro. Cerebellum (London, England). 9 [PubMed]

Prinz AA, Billimoria CP, Marder E. (2003). Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons. Journal of neurophysiology. 90 [PubMed]

Pugh JR, Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron. 51 [PubMed]

Pugh JR, Raman IM. (2008). Mechanisms of potentiation of mossy fiber EPSCs in the cerebellar nuclei by coincident synaptic excitation and inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Purvis LK, Butera RJ. (2005). Ionic current model of a hypoglossal motoneuron. Journal of neurophysiology. 93 [PubMed]

Quaia C, Lefèvre P, Optican LM. (1999). Model of the control of saccades by superior colliculus and cerebellum. Journal of neurophysiology. 82 [PubMed]

RALL W. (1959). Branching dendritic trees and motoneuron membrane resistivity. Experimental neurology. 1 [PubMed]

Raman IM, Gustafson AE, Padgett D. (2000). Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Rivera C et al. (1999). The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature. 397 [PubMed]

Robinson DA. (1976). Adaptive gain control of vestibuloocular reflex by the cerebellum. Journal of neurophysiology. 39 [PubMed]

Rothman JS, Cathala L, Steuber V, Silver RA. (2009). Synaptic depression enables neuronal gain control. Nature. 457 [PubMed]

Rowland NC, Jaeger D. (2005). Coding of tactile response properties in the rat deep cerebellar nuclei. Journal of neurophysiology. 94 [PubMed]

Schmahmann JD. (1991). An emerging concept. The cerebellar contribution to higher function. Archives of neurology. 48 [PubMed]

Schweighofer N, Doya K, Kuroda S. (2004). Cerebellar aminergic neuromodulation: towards a functional understanding. Brain research. Brain research reviews. 44 [PubMed]

Seth AK, Edelman GM. (2007). Distinguishing causal interactions in neural populations. Neural computation. 19 [PubMed]

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML. (1999). Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. Journal of neurophysiology. 82 [PubMed]

Shin SL et al. (2007). Regular patterns in cerebellar Purkinje cell simple spike trains. PloS one. 2 [PubMed]

Stern EA, Jaeger D, Wilson CJ. (1998). Membrane potential synchrony of simultaneously recorded striatal spiny neurons in vivo. Nature. 394 [PubMed]

Steuber V et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron. 54 [PubMed]

Sultan F, Czubayko U, Thier P. (2003). Morphological classification of the rat lateral cerebellar nuclear neurons by principal component analysis. The Journal of comparative neurology. 455 [PubMed]

Surges R et al. (2006). Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. The European journal of neuroscience. 24 [PubMed]

Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW. (2009). Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels (Austin, Tex.). 3 [PubMed]

Taylor AL, Goaillard JM, Marder E. (2009). How multiple conductances determine electrophysiological properties in a multicompartment model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM. (2004). Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron. 41 [PubMed]

Timmann D, Citron R, Watts S, Hore J. (2001). Increased variability in finger position occurs throughout overarm throws made by cerebellar and unskilled subjects. Journal of neurophysiology. 86 [PubMed]

Traboulsie A, Chemin J, Kupfer E, Nargeot J, Lory P. (2006). T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Molecular pharmacology. 69 [PubMed]

Turner RW, Mehaffey WH, Molineux ML, Nejad RT. (2007). Transient and weak bursting deep cerebellar neurons exhibit differential coding properties for membrane hyperpolarizations Society for Neuroscience Abstract 409.12.

Uusisaari M, Obata K, Knöpfel T. (2007). Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Journal of neurophysiology. 97 [PubMed]

Wetmore DZ, Mukamel EA, Schnitzer MJ. (2008). Lock-and-key mechanisms of cerebellar memory recall based on rebound currents. Journal of neurophysiology. 100 [PubMed]

Zheng N, Raman IM. (2009). Ca currents activated by spontaneous firing and synaptic disinhibition in neurons of the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Zhu L, Lovinger D, Delpire E. (2005). Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride. Journal of neurophysiology. 93 [PubMed]

van Kan PL, Houk JC, Gibson AR. (1993). Output organization of intermediate cerebellum of the monkey. Journal of neurophysiology. 69 [PubMed]

References and models that cite this paper

Fardet T, Levina A. (2020). Simple Models Including Energy and Spike Constraints Reproduce Complex Activity Patterns and Metabolic Disruptions PLoS computational biology. 16 [PubMed]

Geminiani A, Casellato C, D'Angelo E, Pedrocchi A. (2019). Complex Electroresponsive Dynamics in Olivocerebellar Neurons Represented With Extended-Generalized Leaky Integrate and Fire Models. Frontiers in computational neuroscience. 13 [PubMed]

Jaeger D et al. (2017). Robust Transmission of Rate Coding in the Inhibitory Purkinje Cell to Cerebellar Nuclei Pathway in Awake Mice PLOS Computational Biology.

Lin RJ, Jaeger D. (2011). Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. Journal of neurophysiology. 105 [PubMed]

Luthman J et al. (2011). STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum (London, England). 10 [PubMed]

Ovsepian SV et al. (2013). A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. The Journal of physiology. 591 [PubMed]

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

Sudhakar SK, Torben-Nielsen B, De Schutter E. (2015). Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses. PLoS computational biology. 11 [PubMed]

Zhang X, Santaniello S. (2019). Role of cerebellar GABAergic dysfunctions in the origins of essential tremor Proceedings of the National Academy of Sciences.

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.