An WF et al. (2000). Modulation of A-type potassium channels by a family of calcium sensors. Nature. 403 [PubMed]
Barry DM, Xu H, Schuessler RB, Nerbonne JM. (1998). Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circulation research. 83 [PubMed]
Beuckelmann DJ, Näbauer M, Erdmann E. (1993). Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circulation research. 73 [PubMed]
Brahmajothi MV et al. (1999). Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. The Journal of general physiology. 113 [PubMed]
Dilks D, Ling HP, Cockett M, Sokol P, Numann R. (1999). Cloning and expression of the human kv4.3 potassium channel. Journal of neurophysiology. 81 [PubMed]
Dixon JE et al. (1996). Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circulation research. 79 [PubMed]
Dumaine R et al. (1999). Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circulation research. 85 [PubMed]
Faivre JF et al. (1999). Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium current. Cardiovascular research. 41 [PubMed]
Flesch M et al. (1996). Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation. 94 [PubMed]
Guo W, Li H, London B, Nerbonne JM. (2000). Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circulation research. 87 [PubMed]
Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archiv : European journal of physiology. 391 [PubMed]
Hoppe UC, Johns DC, Marbán E, O'Rourke B. (1999). Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circulation research. 84 [PubMed]
Jafri MS, Rice JJ, Winslow RL. (1998). Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophysical journal. 74 [PubMed]
Kong W et al. (1998). Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. The American journal of physiology. 275 [PubMed]
Kääb S et al. (1998). Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation. 98 [PubMed]
Kääb S et al. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circulation research. 78 [PubMed]
Li GR, Feng J, Yue L, Carrier M. (1998). Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. The American journal of physiology. 275 [PubMed]
Litovsky SH, Antzelevitch C. (1989). Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. Journal of the American College of Cardiology. 14 [PubMed]
Liu DW, Gintant GA, Antzelevitch C. (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circulation research. 72 [PubMed]
Lukas A, Antzelevitch C. (1993). Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current. Circulation. 88 [PubMed]
Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]
McKinnon D et al. (2000). Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res. 86
Meyer M et al. (1995). Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation. 92
Näbauer M, Beuckelmann DJ, Erdmann E. (1993). Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circulation research. 73 [PubMed]
Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 93 [PubMed]
Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB. (1993). Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circulation research. 72 [PubMed]
Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB. (1992). Functional expression of an inactivating potassium channel cloned from human heart. Circulation research. 71 [PubMed]
Stengl M, Carmeliet E, Mubagwa K, Flameng W. (1998). Modulation of transient outward current by extracellular protons and Cd2+ in rat and human ventricular myocytes. The Journal of physiology. 511 ( Pt 3) [PubMed]
Studer R et al. (1994). Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circulation research. 75 [PubMed]
Wettwer E, Amos GJ, Posival H, Ravens U. (1994). Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circulation research. 75 [PubMed]
Wickenden AD, Jegla TJ, Kaprielian R, Backx PH. (1999). Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. The American journal of physiology. 276 [PubMed]
Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circulation research. 84 [PubMed]
Zagotta WN, Aldrich RW. (1990). Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle. The Journal of general physiology. 95 [PubMed]
Zygmunt AC, Robitelle DC, Eddlestone GT. (1997). Ito1 dictates behavior of ICl(Ca) during early repolarization of canine ventricle. The American journal of physiology. 273 [PubMed]
Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]
Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]
Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]
Greenstein JL, Tanskanen AJ, Winslow RL. (2004). Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Annals of the New York Academy of Sciences. 1015 [PubMed]
Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]
Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]
Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]
Liu YC, Wang YJ, Wu SN. (2008). The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. European journal of pharmacology. 590 [PubMed]
Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation research. 89 [PubMed]
Patel SP, Campbell DL. (2005). Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. The Journal of physiology. 569 [PubMed]
Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. (2005). The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophysical journal. 88 [PubMed]
Winslow RL, Cortassa S, Greenstein JL. (2005). Using models of the myocyte for functional interpretation of cardiac proteomic data. The Journal of physiology. 563 [PubMed]
Arai M, Alpert NR, MacLennan DH, Barton P, Periasamy M. (1993). Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circulation research. 72 [PubMed]
Beuckelmann DJ, Näbauer M, Erdmann E. (1992). Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation. 85 [PubMed]
Beuckelmann DJ, Näbauer M, Erdmann E. (1993). Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circulation research. 73 [PubMed]
Bishop VS, Hasser EM, Nair UC. (1987). Baroreflex control of renal nerve activity in conscious animals. Circulation research. 61 [PubMed]
Bouvier M et al. (1991). Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog. Circ Res. 69
Campbell DL, Rasmusson RL, Qu Y, Strauss HC. (1993). The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. The Journal of general physiology. 101 [PubMed]
Cannell MB, Soeller C. (1997). Numerical analysis of ryanodine receptor activation by L-type channel activity in the cardiac muscle diad. Biophysical journal. 73 [PubMed]
Cory CR et al. (1993). Compensatory downregulation of myocardial Ca channel in SR from dogs with heart failure. The American journal of physiology. 264 [PubMed]
Fiset C, Clark RB, Shimoni Y, Giles WR. (1997). Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle. The Journal of physiology. 500 ( Pt 1) [PubMed]
Flesch M et al. (1996). Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation. 94 [PubMed]
Ginsburg KS, Shannon TR, Bers DM. (1997). SR Ca uptake rate in permeabilizedventricular myocytes is limited by reverse rate of the SR Ca pump Biophys J. 72
Gintant GA. (1995). Regional differences in IK density in canine left ventricle: role of IK,s in electrical heterogeneity. The American journal of physiology. 268 [PubMed]
Gintant GA. (1996). Two components of delayed rectifier current in canine atrium and ventricle. Does IKs play a role in the reverse rate dependence of class III agents? Circulation research. 78 [PubMed]
Gómez AM et al. (1997). Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (New York, N.Y.). 276 [PubMed]
Hasenfuss G et al. (1994). Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circulation research. 75 [PubMed]
Imredy JP, Yue DT. (1994). Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Neuron. 12 [PubMed]
Jafri MS, Rice JJ, Winslow RL. (1998). Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophysical journal. 74 [PubMed]
Johns DC, Nuss HB, Marban E. (1997). Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs. The Journal of biological chemistry. 272 [PubMed]
Kajstura J et al. (1995). The cellular basis of pacing-induced dilated cardiomyopathy. Myocyte cell loss and myocyte cellular reactive hypertrophy. Circulation. 92 [PubMed]
Keizer J, Levine L. (1996). Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations. Biophysical journal. 71 [PubMed]
Kim CH et al. (1994). Isoform-specific regulation of myocardial Na,K-ATPase alpha-subunit in congestive heart failure. Role of norepinephrine. Circulation. 89 [PubMed]
Koumi S, Backer CL, Arentzen CE. (1995). Characterization of inwardly rectifying K+ channel in human cardiac myocytes. Alterations in channel behavior in myocytes isolated from patients with idiopathic dilated cardiomyopathy. Circulation. 92 [PubMed]
Kubicek M. (1983). Computational Methods Bifurcation Theory and Dissipative Structures.
Kääb S et al. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circulation research. 78 [PubMed]
Langer GA, Peskoff A. (1996). Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell. Biophysical journal. 70 [PubMed]
Li HG, Jones DL, Yee R, Klein GJ. (1992). Electrophysiologic substrate associated with pacing-induced heart failure in dogs: potential value of programmed stimulation in predicting sudden death. Journal of the American College of Cardiology. 19 [PubMed]
Limas CJ et al. (1987). Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy. Cardiovascular research. 21 [PubMed]
Liu DW, Antzelevitch C. (1995). Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circulation research. 76 [PubMed]
Liu DW, Gintant GA, Antzelevitch C. (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circulation research. 72 [PubMed]
Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]
Mercadier JJ et al. (1990). Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure. The Journal of clinical investigation. 85 [PubMed]
Meyer M et al. (1995). Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation. 92
Movsesian MA, Bristow MR, Krall J. (1989). Ca2+ uptake by cardiac sarcoplasmic reticulum from patients with idiopathic dilated cardiomyopathy. Circulation research. 65 [PubMed]
Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 93 [PubMed]
O'Rourke B et al. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. Circulation research. 84 [PubMed]
Reinecke H, Studer R, Vetter R, Holtz J, Drexler H. (1996). Cardiac Na+/Ca2+ exchange activity in patients with end-stage heart failure. Cardiovascular research. 31 [PubMed]
Reinecke H et al. (1996). Role of the cardiac sarcolemmal Na(+)-Ca2+ exchanger in end-stage human heart failure. Annals of the New York Academy of Sciences. 779 [PubMed]
Shannon TR, Ginsburg KS, Bers DM. (1998). Reverse mode of the sarcoplasmic reticulum Ca pump limits sarcoplasmic reticulum Ca uptake in permeabilized and voltage-clamped myocytes. Annals of the New York Academy of Sciences. 853 [PubMed]
Soeller C, Cannell MB. (1997). Numerical simulation of local calcium movements during L-type calcium channel gating in the cardiac diad. Biophysical journal. 73 [PubMed]
Spinale FG et al. (1992). Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy. Circulation research. 71 [PubMed]
Spinale FG et al. (1995). LV and myocyte structure and function after early recovery from tachycardia-induced cardiomyopathy. The American journal of physiology. 268 [PubMed]
Stern MD. (1992). Theory of excitation-contraction coupling in cardiac muscle. Biophysical journal. 63 [PubMed]
Studer R et al. (1994). Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circulation research. 75 [PubMed]
Takahashi T et al. (1992). Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. The Journal of clinical investigation. 90 [PubMed]
Tseng GN, Hoffman BF. (1989). Two components of transient outward current in canine ventricular myocytes. Circulation research. 64 [PubMed]
Tseng GN, Robinson RB, Hoffman BF. (1987). Passive properties and membrane currents of canine ventricular myocytes. The Journal of general physiology. 90 [PubMed]
Vermeulen JT et al. (1994). Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts. Cardiovascular research. 28 [PubMed]
Wagner J, Keizer J. (1994). Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations. Biophysical journal. 67 [PubMed]
Williams RE et al. (1994). Endomyocardial gene expression during development of pacing tachycardia-induced heart failure in the dog. Circulation research. 75 [PubMed]
Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]
Zygmunt AC. (1994). Intracellular calcium activates a chloride current in canine ventricular myocytes. The American journal of physiology. 267 [PubMed]
Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B. (2003). An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophysical journal. 84 [PubMed]
Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]
Fox JJ, McHarg JL, Gilmour RF. (2002). Ionic mechanism of electrical alternans. American journal of physiology. Heart and circulatory physiology. 282 [PubMed]
Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]
Greenstein JL, Tanskanen AJ, Winslow RL. (2004). Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Annals of the New York Academy of Sciences. 1015 [PubMed]
Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]
Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL. (2000). Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circulation research. 87 [PubMed]
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004). A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophysical journal. 87 [PubMed]
Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]
Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]
Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]
Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation research. 89 [PubMed]
Michailova A, Saucerman J, Belik ME, McCulloch AD. (2005). Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Biophysical journal. 88 [PubMed]
Puglisi JL, Bers DM. (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American journal of physiology. Cell physiology. 281 [PubMed]
Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. (2005). The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophysical journal. 88 [PubMed]
Winslow RL, Cortassa S, Greenstein JL. (2005). Using models of the myocyte for functional interpretation of cardiac proteomic data. The Journal of physiology. 563 [PubMed]
Winslow RL, Greenstein JL. (2004). The ongoing journey to understand heart function through integrative modeling. Circulation research. 95 [PubMed]