Eyal G et al. (2018). Human Cortical Pyramidal Neurons: From Spines to Spikes via Models. Frontiers in cellular neuroscience. 12 [PubMed]

See more from authors: Eyal G · Verhoog MB · Testa-Silva G · Deitcher Y · Benavides-Piccione R · DeFelipe J · de Kock CPJ · Mansvelder HD · Segev I

References and models cited by this paper

Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. (2008). Gender differences in human cortical synaptic density. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Amunts K et al. (2016). The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain. Neuron. 92 [PubMed]

Angelino E, Brenner MP. (2007). Excitability constraints on voltage-gated sodium channels. PLoS computational biology. 3 [PubMed]

Araya R, Vogels TP, Yuste R. (2014). Activity-dependent dendritic spine neck changes are correlated with synaptic strength. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Arellano JI, Espinosa A, Fairén A, Yuste R, DeFelipe J. (2007). Non-synaptic dendritic spines in neocortex. Neuroscience. 145 [PubMed]

Avoli M, Louvel J, Pumain R, Köhling R. (2005). Cellular and molecular mechanisms of epilepsy in the human brain. Progress in neurobiology. 77 [PubMed]

Ballesteros-Yáñez I, Benavides-Piccione R, Elston GN, Yuste R, DeFelipe J. (2006). Density and morphology of dendritic spines in mouse neocortex. Neuroscience. 138 [PubMed]

Ben-david S, Shalev-Shwartz S. (2014). Understanding Machine Learning: From Theory to Algorithms.

Benavides-Piccione R, Arellano JI, DeFelipe J. (2005). Catecholaminergic innervation of pyramidal neurons in the human temporal cortex. Cerebral cortex (New York, N.Y. : 1991). 15 [PubMed]

Benavides-Piccione R, Ballesteros-Yáñez I, DeFelipe J, Yuste R. (2002). Cortical area and species differences in dendritic spine morphology. Journal of neurocytology. 31 [PubMed]

Benavides-Piccione R, Fernaud-Espinosa I, Robles V, Yuste R, DeFelipe J. (2013). Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions. Cerebral cortex (New York, N.Y. : 1991). 23 [PubMed]

Blazquez-Llorca L, Merchán-Pérez Á, Rodríguez JR, Gascón J, DeFelipe J. (2013). FIB/SEM technology and Alzheimer's disease: three-dimensional analysis of human cortical synapses. Journal of Alzheimer's disease : JAD. 34 [PubMed]

Bono J, Wilmes KA, Clopath C. (2017). Modelling plasticity in dendrites: from single cells to networks. Current opinion in neurobiology. 46 [PubMed]

Brent R. (1976). A new algorithm for minimizing a function of several variables without calculating derivatives. Algorithms For Minimization Without Derivatives.

Cartailler J, Kwon T, Yuste R, Holcman D. (2018). Deconvolution of Voltage Sensor Time Series and Electro-diffusion Modeling Reveal the Role of Spine Geometry in Controlling Synaptic Strength. Neuron. 97 [PubMed]

DeFelipe J. (2015). The anatomical problem posed by brain complexity and size: a potential solution. Frontiers in neuroanatomy. 9 [PubMed]

DeFelipe J, Alonso-Nanclares L, Arellano JI. (2002). Microstructure of the neocortex: comparative aspects. Journal of neurocytology. 31 [PubMed]

DeFelipe J, Fariñas I. (1992). The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Progress in neurobiology. 39 [PubMed]

Deitcher Y et al. (2017). Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex. Cerebral cortex (New York, N.Y. : 1991). 27 [PubMed]

Del Río MR, DeFelipe J. (1994). A study of SMI 32-stained pyramidal cells, parvalbumin-immunoreactive chandelier cells, and presumptive thalamocortical axons in the human temporal neocortex. The Journal of comparative neurology. 342 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Doron M, Chindemi G, Muller E, Markram H, Segev I. (2017). Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons. Cell reports. 21 [PubMed]

Druckmann S et al. (2007). A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data. Frontiers in neuroscience. 1 [PubMed]

Egger R, Dercksen VJ, Udvary D, Hege HC, Oberlaender M. (2014). Generation of dense statistical connectomes from sparse morphological data. Frontiers in neuroanatomy. 8 [PubMed]

Elston GN, Benavides-Piccione R, DeFelipe J. (2001). The pyramidal cell in cognition: a comparative study in human and monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Eyal G, Mansvelder HD, de Kock CP, Segev I. (2014). Dendrites impact the encoding capabilities of the axon. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Eyal G et al. (2016). Unique membrane properties and enhanced signal processing in human neocortical neurons. eLife. 5 [PubMed]

Farinella M, Ruedt DT, Gleeson P, Lanore F, Silver RA. (2014). Glutamate-bound NMDARs arising from in vivo-like network activity extend spatio-temporal integration in a L5 cortical pyramidal cell model. PLoS computational biology. 10 [PubMed]

Feldmeyer D, Lübke J, Sakmann B. (2006). Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats. The Journal of physiology. 575 [PubMed]

Feldmeyer D, Lübke J, Silver RA, Sakmann B. (2002). Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. The Journal of physiology. 538 [PubMed]

Garey LJ. (2006). Brodmann's ‘Localisation in the Cerebral Cortex.

Harnett MT, Makara JK, Spruston N, Kath WL, Magee JC. (2012). Synaptic amplification by dendritic spines enhances input cooperativity. Nature. 491 [PubMed]

Hawrylycz M et al. (2016). Inferring cortical function in the mouse visual system through large-scale systems neuroscience. Proceedings of the National Academy of Sciences of the United States of America. 113 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Hay E, Schürmann F, Markram H, Segev I. (2013). Preserving axosomatic spiking features despite diverse dendritic morphology. Journal of neurophysiology. 109 [PubMed]

Hay E, Segev I. (2015). Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Herz AV, Gollisch T, Machens CK, Jaeger D. (2006). Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science (New York, N.Y.). 314 [PubMed]

Hines ML, Carnevale NT. (2006). The NEURON Book.

Jadi MP, Behabadi BF, Poleg-Polsky A, Schiller J, Mel BW. (2014). An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites. Proceedings of the IEEE. Institute of Electrical and Electronics Engineers. 102 [PubMed]

Jahr CE, Stevens CF. (1990). Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Kasthuri N et al. (2015). Saturated Reconstruction of a Volume of Neocortex. Cell. 162 [PubMed]

Koch C, Jones A. (2016). Big Science, Team Science, and Open Science for Neuroscience. Neuron. 92 [PubMed]

Koch C, Poggio T, Torre V. (1982). Retinal ganglion cells: a functional interpretation of dendritic morphology. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 298 [PubMed]

Koch C, Segev I. (2000). The role of single neurons in information processing. Nature neuroscience. 3 Suppl [PubMed]

Kole MH, Stuart GJ. (2012). Signal processing in the axon initial segment. Neuron. 73 [PubMed]

Kwon T, Sakamoto M, Peterka DS, Yuste R. (2017). Attenuation of Synaptic Potentials in Dendritic Spines. Cell reports. 20 [PubMed]

Köhling R, Avoli M. (2006). Methodological approaches to exploring epileptic disorders in the human brain in vitro. Journal of neuroscience methods. 155 [PubMed]

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J. (2009). Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science (New York, N.Y.). 325 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature. 398 [PubMed]

Lavzin M, Rapoport S, Polsky A, Garion L, Schiller J. (2012). Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo. Nature. 490 [PubMed]

Lein E, Borm LE, Linnarsson S. (2017). The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing. Science (New York, N.Y.). 358 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

Major G, Larkum ME, Schiller J. (2013). Active properties of neocortical pyramidal neuron dendrites. Annual review of neuroscience. 36 [PubMed]

Markram H, Lübke J, Frotscher M, Roth A, Sakmann B. (1997). Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. The Journal of physiology. 500 ( Pt 2) [PubMed]

Markram H, Lübke J, Frotscher M, Sakmann B. (1997). Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science (New York, N.Y.). 275 [PubMed]

Markram H et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 163 [PubMed]

Martin CL, Chun M. (2016). The BRAIN Initiative: Building, Strengthening, and Sustaining. Neuron. 92 [PubMed]

McCulloch WS, Pitts W. (1990). A logical calculus of the ideas immanent in nervous activity. 1943. Bulletin of mathematical biology. 52 [PubMed]

Mel BW. (1992). NMDA-based pattern discrimination in a modeled cortical neuron. Neural Comput. 4

Mel BW, Schiller J, Poirazi P. (2017). Synaptic plasticity in dendrites: complications and coping strategies. Current opinion in neurobiology. 43 [PubMed]

Mohan H et al. (2015). Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Molnár G et al. (2016). Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles. eLife. 5 [PubMed]

Palmer LM et al. (2014). NMDA spikes enhance action potential generation during sensory input. Nature neuroscience. 17 [PubMed]

Palmer LM, Stuart GJ. (2009). Membrane potential changes in dendritic spines during action potentials and synaptic input. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Polsky A, Mel BW, Schiller J. (2004). Computational subunits in thin dendrites of pyramidal cells. Nature neuroscience. 7 [PubMed]

Poo MM et al. (2016). China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing. Neuron. 92 [PubMed]

Popovic MA, Carnevale N, Rozsa B, Zecevic D. (2015). Electrical behaviour of dendritic spines as revealed by voltage imaging. Nature communications. 6 [PubMed]

RALL W. (1959). Branching dendritic trees and motoneuron membrane resistivity. Experimental neurology. 1 [PubMed]

Rall W. (1964). Theoretical significance of dendritic trees for neuronal input output relations Neural Theory and Modeling.

Rall W. (1967). Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. Journal of neurophysiology. 30 [PubMed]

Rall W. (1969). Time constants and electrotonic length of membrane cylinders and neurons. Biophysical journal. 9 [PubMed]

Rall W, Burke RE, Smith TG, Nelson PG, Frank K. (1967). Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. Journal of neurophysiology. 30 [PubMed]

Ranjan R et al. (2011). Channelpedia: an integrative and interactive database for ion channels. Frontiers in neuroinformatics. 5 [PubMed]

Rhodes P. (2006). The properties and implications of NMDA spikes in neocortical pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Sarid L, Bruno R, Sakmann B, Segev I, Feldmeyer D. (2007). Modeling a layer 4-to-layer 2/3 module of a single column in rat neocortex: interweaving in vitro and in vivo experimental observations. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Sarid L, Feldmeyer D, Gidon A, Sakmann B, Segev I. (2015). Contribution of intracolumnar layer 2/3-to-layer 2/3 excitatory connections in shaping the response to whisker deflection in rat barrel cortex. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Schmidt-Hieber C et al. (2017). Active dendritic integration as a mechanism for robust and precise grid cell firing. Nature neuroscience. 20 [PubMed]

Segev I, Friedman A, White EL, Gutnick MJ. (1995). Electrical consequences of spine dimensions in a model of a cortical spiny stellate cell completely reconstructed from serial thin sections. Journal of computational neuroscience. 2 [PubMed]

Segev I, Yarom Y, Rapp M. (1992). The impact of parallel fiber background activity on the cable properties of cerebellar Purkinje cells Neural Comput. 4

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML. (1999). Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. Journal of neurophysiology. 82 [PubMed]

Shimizu E, Tang YP, Rampon C, Tsien JZ. (2000). NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science (New York, N.Y.). 290 [PubMed]

Siraisi NG. (2007). David Gentilcore, Medical charlatanism in early modern Italy, Oxford: Oxford University Press, 2006. Pp. 448. Pounds 65.00. ISBN 0199245355. Soc Hist Med. 20 [PubMed]

Smith SL, Smith IT, Branco T, Häusser M. (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature. 503 [PubMed]

Spruston N. (2008). Pyramidal neurons: dendritic structure and synaptic integration. Nature reviews. Neuroscience. 9 [PubMed]

Stuart GJ, Sakmann B. (1994). Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature. 367 [PubMed]

Svoboda K, Tank DW, Denk W. (1996). Direct measurement of coupling between dendritic spines and shafts. Science (New York, N.Y.). 272 [PubMed]

Szabadics J et al. (2006). Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science (New York, N.Y.). 311 [PubMed]

Takahashi N, Oertner TG, Hegemann P, Larkum ME. (2016). Active cortical dendrites modulate perception. Science (New York, N.Y.). 354 [PubMed]

Testa-Silva G et al. (2010). Human synapses show a wide temporal window for spike-timing-dependent plasticity. Frontiers in synaptic neuroscience. 2 [PubMed]

Testa-Silva G et al. (2014). High bandwidth synaptic communication and frequency tracking in human neocortex. PLoS biology. 12 [PubMed]

Tian C, Wang K, Ke W, Guo H, Shu Y. (2014). Molecular identity of axonal sodium channels in human cortical pyramidal cells. Frontiers in cellular neuroscience. 8 [PubMed]

Tønnesen J, Katona G, Rózsa B, Nägerl UV. (2014). Spine neck plasticity regulates compartmentalization of synapses. Nature neuroscience. 17 [PubMed]

Varga C, Tamas G, Barzo P, Olah S, Somogyi P. (2015). Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Verhoog MB et al. (2013). Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Wuarin JP, Peacock WJ, Dudek FE. (1992). Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy. Journal of neurophysiology. 67 [PubMed]

References and models that cite this paper

Aberra AS, Peterchev AV, Grill WM. (2018). Biophysically realistic neuron models for simulation of cortical stimulation. Journal of neural engineering. 15 [PubMed]

Masoli S et al. (2024). Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity. Communications biology. 7 [PubMed]

Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK. (2021). Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons. Cerebral cortex (New York, N.Y. : 1991). 31 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.