A model for a nociceptor terminal and terminal tree (Barkai et al., 2020)


Barkai O, Butterman R, Katz B, Lev S, Binshtok AM. (2020). The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40 [PubMed]

See more from authors: Barkai O · Butterman R · Katz B · Lev S · Binshtok AM

References and models cited by this paper

Adrian ED, Zotterman Y. (1926). The impulses produced by sensory nerve-endings: Part II. The response of a Single End-Organ. The Journal of physiology. 61 [PubMed]

Amir R, Michaelis M, Devor M. (1999). Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Araya R, Vogels TP, Yuste R. (2014). Activity-dependent dendritic spine neck changes are correlated with synaptic strength. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Baker MD. (2005). Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones. The Journal of physiology. 567 [PubMed]

Baker MD, Chandra SY, Ding Y, Waxman SG, Wood JN. (2003). GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. The Journal of physiology. 548 [PubMed]

Basbaum AI, Bautista DM, Scherrer G, Julius D. (2009). Cellular and molecular mechanisms of pain. Cell. 139 [PubMed]

Beaulieu-Laroche L, Harnett MT. (2018). Dendritic Spines Prevent Synaptic Voltage Clamp. Neuron. 97 [PubMed]

Bekkers JM. (2011). Changes in dendritic axial resistance alter synaptic integration in cerebellar Purkinje cells. Biophysical journal. 100 [PubMed]

Blair NT, Bean BP. (2002). Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Choi JS, Waxman SG. (2011). Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study. Journal of neurophysiology. 106 [PubMed]

Cummins TR et al. (1999). A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. (2010). Sodium channels in normal and pathological pain. Annual review of neuroscience. 33 [PubMed]

Dubin AE, Patapoutian A. (2010). Nociceptors: the sensors of the pain pathway. The Journal of clinical investigation. 120 [PubMed]

Ferrante M, Migliore M, Ascoli GA. (2013). Functional impact of dendritic branch-point morphology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Gemes G et al. (2013). Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury. The Journal of physiology. 591 [PubMed]

Gidon A, Segev I. (2012). Principles governing the operation of synaptic inhibition in dendrites. Neuron. 75 [PubMed]

Gold MS, Gebhart GF. (2010). Nociceptor sensitization in pain pathogenesis. Nature medicine. 16 [PubMed]

Grubb MS et al. (2011). Short- and long-term plasticity at the axon initial segment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Grunditz A, Holbro N, Tian L, Zuo Y, Oertner TG. (2008). Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Gulledge AT, Bravo JJ. (2016). Neuron Morphology Influences Axon Initial Segment Plasticity. eNeuro. 3 [PubMed]

Herzog RI, Cummins TR, Waxman SG. (2001). Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. Journal of neurophysiology. 86 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Jadi M, Polsky A, Schiller J, Mel BW. (2012). Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]

Jamieson J, Boyd HD, McLachlan EM. (2003). Simulations to derive membrane resistivity in three phenotypes of guinea pig sympathetic postganglionic neuron. Journal of neurophysiology. 89 [PubMed]

Johansson RS, Birznieks I. (2004). First spikes in ensembles of human tactile afferents code complex spatial fingertip events. Nature neuroscience. 7 [PubMed]

Kispersky TJ, Caplan JS, Marder E. (2012). Increase in sodium conductance decreases firing rate and gain in model neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Kuba H, Ishii TM, Ohmori H. (2006). Axonal site of spike initiation enhances auditory coincidence detection. Nature. 444 [PubMed]

Kuba H, Oichi Y, Ohmori H. (2010). Presynaptic activity regulates Na(+) channel distribution at the axon initial segment. Nature. 465 [PubMed]

Lesniak DR et al. (2014). Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors. eLife. 3 [PubMed]

Liu CN, Michaelis M, Amir R, Devor M. (2000). Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. Journal of neurophysiology. 84 [PubMed]

Magee JC. (2000). Dendritic integration of excitatory synaptic input. Nature reviews. Neuroscience. 1 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

Magee JC, Johnston D. (2005). Plasticity of dendritic function. Current opinion in neurobiology. 15 [PubMed]

Mainen ZF, Sejnowski TJ. (1996). Influence of dendritic structure on firing pattern in model neocortical neurons. Nature. 382 [PubMed]

Manor Y, Koch C, Segev I. (1991). Effect of geometrical irregularities on propagation delay in axonal trees. Biophysical journal. 60 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Miyasho T et al. (2001). Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain research. 891 [PubMed]

Nimchinsky EA, Sabatini BL, Svoboda K. (2002). Structure and function of dendritic spines. Annual review of physiology. 64 [PubMed]

Olivares E et al. (2015). TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor. PloS one. 10 [PubMed]

Panzeri S, Petersen RS, Schultz SR, Lebedev M, Diamond ME. (2001). The role of spike timing in the coding of stimulus location in rat somatosensory cortex. Neuron. 29 [PubMed]

Rho YA, Prescott SA. (2012). Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS computational biology. 8 [PubMed]

Sandkühler J. (2009). Models and mechanisms of hyperalgesia and allodynia. Physiological reviews. 89 [PubMed]

Segev I, Rall W. (1988). Computational study of an excitable dendritic spine. Journal of neurophysiology. 60 [PubMed]

Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. (2008). Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Sjöström PJ, Rancz EA, Roth A, Häusser M. (2008). Dendritic excitability and synaptic plasticity. Physiological reviews. 88 [PubMed]

Sundt D, Gamper N, Jaffe DB. (2015). Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. Journal of neurophysiology. 114 [PubMed]

Waxman SG, Zamponi GW. (2014). Regulating excitability of peripheral afferents: emerging ion channel targets. Nature neuroscience. 17 [PubMed]

Weidner C, Schmidt R, Schmelz M, Torebjork HE, Handwerker HO. (2003). Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents. The Journal of physiology. 547 [PubMed]

Williams SR, Stuart GJ. (2003). Role of dendritic synapse location in the control of action potential output. Trends in neurosciences. 26 [PubMed]

Woolf CJ, Ma Q. (2007). Nociceptors--noxious stimulus detectors. Neuron. 55 [PubMed]

Yamada R, Kuba H. (2016). Structural and Functional Plasticity at the Axon Initial Segment. Frontiers in cellular neuroscience. 10 [PubMed]

Zylka MJ, Rice FL, Anderson DJ. (2005). Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 45 [PubMed]

References and models that cite this paper

Marra C, Hartke TV, Ringkamp M, Goldfarb M. (2023). Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception Pain. 164 [PubMed]

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