Cerebellar purkinje cell: interacting Kv3 and Na currents influence firing (Akemann, Knopfel 2006)


Akemann W, Knöpfel T. (2006). Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

See more from authors: Akemann W · Knöpfel T

References and models cited by this paper

Adelman JP, Maylie J, Zerr P. (1998). Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency. J Neurosci. 18

Armstrong DM, Rawson JA. (1979). Activity patterns of cerebellar cortical neurones and climbing fibre afferents in the awake cat. The Journal of physiology. 289 [PubMed]

Atzori M et al. (2000). H2 histamine receptor-phosphorylation of Kv3.2 modulates interneuron fast spiking. Nature neuroscience. 3 [PubMed]

Bal T, McCormick DA. (1997). Synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current I(h). Journal of neurophysiology. 77 [PubMed]

Behnisch T, Matsushita S, Knöpfel T. (2004). Imaging of gene expression during long-term potentiation. Neuroreport. 15 [PubMed]

Benardo LS, Foster RE. (1986). Oscillatory behavior in inferior olive neurons: mechanism, modulation, cell aggregates. Brain research bulletin. 17 [PubMed]

Cerminara NL, Rawson JA. (2004). Evidence that climbing fibers control an intrinsic spike generator in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Chan E. (1997). Regulation and function of Kv3.3 PhD thesis.

Chung YH, Joo KM, Kim MJ, Cha CI. (2003). Age-related changes in the distribution of Na(v)1.1 and Na(v)1.2 in rat cerebellum. Neuroreport. 14 [PubMed]

Do MT, Bean BP. (2003). Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 39 [PubMed]

Do MT, Bean BP. (2004). Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. Journal of neurophysiology. 92 [PubMed]

Edgerton JR, Reinhart PH. (2003). Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. The Journal of physiology. 548 [PubMed]

Erisir A, Lau D, Rudy B, Leonard CS. (1999). Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. Journal of neurophysiology. 82 [PubMed]

GRANIT R, PHILLIPS CG. (1956). Excitatory and inhibitory processes acting upon individual Purkinje cells of the cerebellum in cats. The Journal of physiology. 133 [PubMed]

Goldman-Wohl DS, Chan E, Baird D, Heintz N. (1994). Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 14 [PubMed]

Grieco TM, Malhotra JD, Chen C, Isom LL, Raman IM. (2005). Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 45 [PubMed]

Grieco TM, Raman IM. (2004). Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Häusser M, Clark BA. (1997). Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron. 19 [PubMed]

Häusser M et al. (2004). The beat goes on: spontaneous firing in mammalian neuronal microcircuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Itri JN, Michel S, Vansteensel MJ, Meijer JH, Colwell CS. (2005). Fast delayed rectifier potassium current is required for circadian neural activity. Nature neuroscience. 8 [PubMed]

Joho RH, Street C, Matsushita S, Knöpfel T. (2006). Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice Genes, Brain and Behavior. 5

Kay AR, Sugimori M, Llinás R. (1998). Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells. Journal of neurophysiology. 80 [PubMed]

Khaliq ZM, Gouwens NW, Raman IM. (2003). The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Kohrman DC, Smith MR, Goldin AL, Harris J, Meisler MH. (1996). A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Kullmann PH, Wheeler DW, Beacom J, Horn JP. (2004). Implementation of a fast 16-Bit dynamic clamp using LabVIEW-RT. Journal of neurophysiology. 91 [PubMed]

Lien CC, Jonas P. (2003). Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Llinás R, Sugimori M. (1980). Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. The Journal of physiology. 305 [PubMed]

Llinás R, Yarom Y. (1986). Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation: an in vitro study. The Journal of physiology. 376 [PubMed]

Martina M, Yao GL, Bean BP. (2003). Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Matsukawa H, Wolf AM, Matsushita S, Joho RH, Knöpfel T. (2003). Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

McKay BE, Molineux ML, Mehaffey WH, Turner RW. (2005). Kv1 K+ channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

McKay BE, Turner RW. (2004). Kv3 K+ channels enable burst output in rat cerebellar Purkinje cells. The European journal of neuroscience. 20 [PubMed]

McMahon A et al. (2004). Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3. The European journal of neuroscience. 19 [PubMed]

Nelson AB, Krispel CM, Sekirnjak C, du Lac S. (2003). Long-lasting increases in intrinsic excitability triggered by inhibition. Neuron. 40 [PubMed]

Raman IM, Bean BP. (1997). Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Raman IM, Bean BP. (1999). Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Raman IM, Bean BP. (2001). Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophysical journal. 80 [PubMed]

Raman IM, Sprunger LK, Meisler MH, Bean BP. (1997). Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron. 19 [PubMed]

Rudy B et al. (1999). Contributions of Kv3 channels to neuronal excitability. Annals of the New York Academy of Sciences. 868 [PubMed]

Rudy B, McBain CJ. (2001). Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends in neurosciences. 24 [PubMed]

Sacco T, Tempia F. (2002). A-type potassium currents active at subthreshold potentials in mouse cerebellar Purkinje cells. The Journal of physiology. 543 [PubMed]

Sausbier M et al. (2004). Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proceedings of the National Academy of Sciences of the United States of America. 101 [PubMed]

Schaller KL, Caldwell JH. (2003). Expression and distribution of voltage-gated sodium channels in the cerebellum. Cerebellum (London, England). 2 [PubMed]

Shah BS, Stevens EB, Pinnock RD, Dixon AK, Lee K. (2001). Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS. The Journal of physiology. 534 [PubMed]

Smith SL, Otis TS. (2003). Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Song P et al. (2005). Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature neuroscience. 8 [PubMed]

Takahashi E, Nagasu T. (2005). Pattern of compensatory expression of voltage-dependent Ca2+ channel alpha1 and beta subunits in brain of N-type Ca2+ channel alpha1B subunit gene-deficient mice with a CBA/JN genetic background. Experimental animals. 54 [PubMed]

Vega-Saenz de Miera EC, Rudy B, Sugimori M, Llinás R. (1997). Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America. 94 [PubMed]

Weiser M et al. (1994). Differential expression of Shaw-related K+ channels in the rat central nervous system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 14 [PubMed]

Williams SR, Christensen SR, Stuart GJ, Häusser M. (2002). Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro. The Journal of physiology. 539 [PubMed]

Womack MD, Khodakhah K. (2002). Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons. The European journal of neuroscience. 16 [PubMed]

Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N. (2003). Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. The Journal of biological chemistry. 278 [PubMed]

von Hehn CA, Bhattacharjee A, Kaczmarek LK. (2004). Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

References and models that cite this paper

Akemann W, Lundby A, Mutoh H, Knöpfel T. (2009). Effect of voltage sensitive fluorescent proteins on neuronal excitability. Biophysical journal. 96 [PubMed]

Almog M, Korngreen A. (2014). A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Anwar H, Hong S, De Schutter E. (2012). Controlling Ca2+-activated K+ channels with models of Ca2+ buffering in Purkinje cells. Cerebellum (London, England). 11 [PubMed]

Carnevale NT, Morse TM. (1996). Research reports that have used NEURON Web published citations at the NEURON website.

Couto J, Linaro D, De Schutter E, Giugliano M. (2015). On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro. PLoS computational biology. 11 [PubMed]

Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK. (2008). Protein kinase C modulates inactivation of Kv3.3 channels. The Journal of biological chemistry. 283 [PubMed]

Forrest MD. (2015). Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster. BMC neuroscience. 16 [PubMed]

Frey U, Egert U, Heer F, Hafizovic S, Hierlemann A. (2009). Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. Biosensors & bioelectronics. 24 [PubMed]

Huang S, Hong S, De Schutter E. (2015). Non-linear leak currents affect mammalian neuron physiology. Frontiers in cellular neuroscience. 9 [PubMed]

Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience. 11 [PubMed]

Masoli S, Ottaviani A, Casali S, D'Angelo E. (2020). Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS computational biology. 16 [PubMed]

Masoli S, Solinas S, D'Angelo E. (2015). Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization. Frontiers in cellular neuroscience. 9 [PubMed]

Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. (2007). Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Smith P, Buhl E, Tsaneva-Atanasova K, Hodge JJL. (2019). Shaw and Shal voltage-gated potassium channels mediate circadian changes in Drosophila clock neuron excitability. The Journal of physiology. 597 [PubMed]

Traub RD, Middleton SJ, Knöpfel T, Whittington MA. (2008). Model of very fast (greater than 75 Hz) network oscillations generated by electrical coupling between the proximal axons of cerebellar Purkinje cells. The European journal of neuroscience. 28 [PubMed]

Zang Y, Hong S, De Schutter E. (2020). Firing rate-dependent phase responses of Purkinje cells support transient oscillations. eLife. 9 [PubMed]

Zemel BM et al. (2021). Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control Nature communications. 12 [PubMed]

Zhang X, Santaniello S. (2019). Role of cerebellar GABAergic dysfunctions in the origins of essential tremor Proceedings of the National Academy of Sciences.

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.