Khaliq ZM, Gouwens NW, Raman IM. (2003). The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

See more from authors: Khaliq ZM · Gouwens NW · Raman IM

References and models cited by this paper

Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M. (2001). Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature. 409 [PubMed]

Burgess DL et al. (1995). Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'. Nature genetics. 10 [PubMed]

Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR. (2000). Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

Cingolani LA, Gymnopoulos M, Boccaccio A, Stocker M, Pedarzani P. (2002). Developmental regulation of small-conductance Ca2+-activated K+ channel expression and function in rat Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

D'Angelo E et al. (2001). Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

De Schutter E, Bower JM. (1994). An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. Journal of neurophysiology. 71 [PubMed]

Do MT, Bean BP. (2003). Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 39 [PubMed]

Duchen LW, Searle AG. (1970). Hereditary motor endplate disease in the mouse: light and electron microscopic studies J Neurol Neurosurg Psychiat. 33

Edgerton JR, Reinhart PH. (2003). Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. The Journal of physiology. 548 [PubMed]

Felts PA, Yokoyama S, Dib-Hajj S, Black JA, Waxman SG. (1997). Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain research. Molecular brain research. 45 [PubMed]

GRANIT R, PHILLIPS CG. (1956). Excitatory and inhibitory processes acting upon individual Purkinje cells of the cerebellum in cats. The Journal of physiology. 133 [PubMed]

García KD, Sprunger LK, Meisler MH, Beam KG. (1998). The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Golowasch J, Abbott LF, Marder E. (1999). Activity-dependent regulation of potassium currents in an identified neuron of the stomatogastric ganglion of the crab Cancer borealis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Golowasch J, Casey M, Abbott LF, Marder E. (1999). Network stability from activity-dependent regulation of neuronal conductances. Neural computation. 11 [PubMed]

Golowasch J, Goldman MS, Abbott LF, Marder E. (2002). Failure of averaging in the construction of a conductance-based neuron model. Journal of neurophysiology. 87 [PubMed]

Grieco TM, Afshari FS, Raman IM. (2002). A role for phosphorylation in the maintenance of resurgent sodium current in cerebellar purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Gähwiler BH, Llano I. (1989). Sodium and potassium conductances in somatic membranes of rat Purkinje cells from organotypic cerebellar cultures. The Journal of physiology. 417 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Harris JB, Boakes RJ, Court JA. (1992). . J Neurol Sci. 110

Hille B. (2001). Classic mechanisms of block Ion Channels of Excitable Membranes (3rd edn).

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Huguenard JR, McCormick DA. (1992). Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. Journal of neurophysiology. 68 [PubMed]

Häusser M, Clark BA. (1997). Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron. 19 [PubMed]

Jaeger D, De Schutter E, Bower JM. (1997). The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Jarolimek W, Soman KV, Brown AM, Alam M. (1995). The selectivity of different external binding sites for quaternary ammonium ions in cloned potassium channels. Pflugers Archiv : European journal of physiology. 430 [PubMed]

Kearney JA et al. (2002). Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6). Human molecular genetics. 11 [PubMed]

Kohrman DC, Harris JB, Meisler MH. (1996). Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron. The Journal of biological chemistry. 271 [PubMed]

Kohrman DC, Smith MR, Goldin AL, Harris J, Meisler MH. (1996). A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Latham A, Paul DH. (1971). Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibres. The Journal of physiology. 213 [PubMed]

Llinás R, Sugimori M. (1980). Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. The Journal of physiology. 305 [PubMed]

MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM. (2003). Activity-independent homeostasis in rhythmically active neurons. Neuron. 37 [PubMed]

Maurice N, Tkatch T, Meisler M, Sprunger LK, Surmeier DJ. (2001). D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

McCormick DA, Huguenard JR. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. Journal of neurophysiology. 68 [PubMed]

McDonough SI, Bean BP. (1998). Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons. Molecular pharmacology. 54 [PubMed]

Mintz IM, Adams ME, Bean BP. (1992). P-type calcium channels in rat central and peripheral neurons. Neuron. 9 [PubMed]

Nam SC, Hockberger PE. (1997). Analysis of spontaneous electrical activity in cerebellar Purkinje cells acutely isolated from postnatal rats. Journal of neurobiology. 33 [PubMed]

Pan F, Beam KG. (1999). The absence of resurgent sodium current in mouse spinal neurons. Brain research. 849 [PubMed]

Raman IM, Bean BP. (1997). Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Raman IM, Bean BP. (1999). Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Raman IM, Bean BP. (2001). Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophysical journal. 80 [PubMed]

Raman IM, Gustafson AE, Padgett D. (2000). Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Raman IM, Sprunger LK, Meisler MH, Bean BP. (1997). Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron. 19 [PubMed]

Regan LJ. (1991). Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 11 [PubMed]

Rudy B et al. (1999). Contributions of Kv3 channels to neuronal excitability. Annals of the New York Academy of Sciences. 868 [PubMed]

Rudy B, McBain CJ. (2001). Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends in neurosciences. 24 [PubMed]

Sacco T, Tempia F. (2002). A-type potassium currents active at subthreshold potentials in mouse cerebellar Purkinje cells. The Journal of physiology. 543 [PubMed]

Schaller KL, Caldwell JH. (2000). Developmental and regional expression of sodium channel isoform NaCh6 in the rat central nervous system. The Journal of comparative neurology. 420 [PubMed]

Schaller KL, Krzemien DM, Yarowsky PJ, Krueger BK, Caldwell JH. (1995). A novel, abundant sodium channel expressed in neurons and glia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 15 [PubMed]

Slater NT, Mossadeghi B. (1998). Persistent and resurgent sodium currents in cerebellar unipolar brush cells Soc Neurosci Abstr. 24

Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL. (1998). Functional analysis of the mouse Scn8a sodium channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Southan AP, Robertson B. (2000). Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Stefani E, Duchen LW. (1971). of the mouse. J Physiol. 212

Taglialatela M et al. (1991). Patterns of internal and external tetraethylammonium block in four homologous K+ channels. Molecular pharmacology. 40 [PubMed]

Thach WT. (1968). Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. Journal of neurophysiology. 31 [PubMed]

Velumian AA, Zhang L, Pennefather P, Carlen PL. (1997). Reversible inhibition of IK, IAHP, Ih and ICa currents by internally applied gluconate in rat hippocampal pyramidal neurones. Pflugers Archiv : European journal of physiology. 433 [PubMed]

Womack M, Khodakhah K. (2002). Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Womack MD, Khodakhah K. (2002). Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons. The European journal of neuroscience. 16 [PubMed]

Womack MD, Khodakhah K. (2003). Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Zhang L et al. (1994). Whole-cell recording of the Ca(2+)-dependent slow afterhyperpolarization in hippocampal neurones: effects of internally applied anions. Pflugers Archiv : European journal of physiology. 426 [PubMed]

Zhang Y, Mori M, Burgess DL, Noebels JL. (2002). Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

References and models that cite this paper

Akemann W, Knöpfel T. (2006). Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Akemann W, Lundby A, Mutoh H, Knöpfel T. (2009). Effect of voltage sensitive fluorescent proteins on neuronal excitability. Biophysical journal. 96 [PubMed]

Almog M, Korngreen A. (2014). A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Anwar H, Hong S, De Schutter E. (2012). Controlling Ca2+-activated K+ channels with models of Ca2+ buffering in Purkinje cells. Cerebellum (London, England). 11 [PubMed]

Carnevale NT, Morse TM. (1996). Research reports that have used NEURON Web published citations at the NEURON website.

Couto J, Linaro D, De Schutter E, Giugliano M. (2015). On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro. PLoS computational biology. 11 [PubMed]

Dover K et al. (2016). FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nature communications. 7 [PubMed]

Feng B, Zhu Y, La JH, Wills ZP, Gebhart GF. (2015). Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. Journal of neurophysiology. 113 [PubMed]

Fernandez FR, Engbers JD, Turner RW. (2007). Firing dynamics of cerebellar purkinje cells. Journal of neurophysiology. 98 [PubMed]

Forrest MD. (2015). Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster. BMC neuroscience. 16 [PubMed]

Frey U, Egert U, Heer F, Hafizovic S, Hierlemann A. (2009). Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. Biosensors & bioelectronics. 24 [PubMed]

Gertler TS, Chan CS, Surmeier DJ. (2008). Dichotomous anatomical properties of adult striatal medium spiny neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Huang S, Hong S, De Schutter E. (2015). Non-linear leak currents affect mammalian neuron physiology. Frontiers in cellular neuroscience. 9 [PubMed]

Häusser M et al. (2004). The beat goes on: spontaneous firing in mammalian neuronal microcircuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Kuo JJ, Lee RH, Zhang L, Heckman CJ. (2006). Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones. The Journal of physiology. 574 [PubMed]

Leão RN, Naves MM, Leão KE, Walmsley B. (2006). Altered sodium currents in auditory neurons of congenitally deaf mice. The European journal of neuroscience. 24 [PubMed]

Magistretti J, Castelli L, Forti L, D'Angelo E. (2006). Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: an electrophysiological and modelling study. The Journal of physiology. 573 [PubMed]

Manis PB, Campagnola L. (2018). A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks. Hearing research. 360 [PubMed]

Masoli S, Ottaviani A, Casali S, D'Angelo E. (2020). Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS computational biology. 16 [PubMed]

Masoli S, Solinas S, D'Angelo E. (2015). Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization. Frontiers in cellular neuroscience. 9 [PubMed]

Maurice N et al. (2004). D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. (2007). Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Montefusco F, Tagliavini A, Ferrante M, Pedersen MG. (2017). Concise Whole-Cell Modeling of BKCa-CaV Activity Controlled by Local Coupling and Stoichiometry. Biophysical journal. 112 [PubMed]

Nicoletti M et al. (2024). Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families. PloS one. 19 [PubMed]

Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]

Schultheiss NW, Edgerton JR, Jaeger D. (2010). Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Venugopal S et al. (2019). Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PLoS computational biology. 15 [PubMed]

Zang Y, Dieudonné S, De Schutter E. (2018). Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell reports. 24 [PubMed]

Zang Y, Hong S, De Schutter E. (2020). Firing rate-dependent phase responses of Purkinje cells support transient oscillations. eLife. 9 [PubMed]

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