Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++)

Backx PH, Marban E. (1993). Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes. Circulation research. 72 [PubMed]

Balke CW, Rose WC, Marban E, Wier WG. (1992). Macroscopic and unitary properties of physiological ion flux through T-type Ca2+ channels in guinea-pig heart cells. The Journal of physiology. 456 [PubMed]

Balser JR, Bennett PB, Roden DM. (1990). Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier. The Journal of general physiology. 96 [PubMed]

Bass BG. (1975). Restitution of the action potential in cat papillary muscle. The American journal of physiology. 228 [PubMed]

Beeler GW, Reuter H. (1977). Reconstruction of the action potential of ventricular myocardial fibres. The Journal of physiology. 268 [PubMed]

• Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Bjørnstad H, Tande PM, Lathrop DA, Refsum H. (1993). Effects of temperature on cycle length dependent changes and restitution of action potential duration in guinea pig ventricular muscle. Cardiovascular research. 27 [PubMed]

Boyett MR, Jewell BR. (1978). A study of the factors responsible for rate-dependent shortening of the action potential in mammalian ventricular muscle. The Journal of physiology. 285 [PubMed]

Carmeliet E. (1990). The cardiac action potential Cardiac Electrophysiology: A Textbook.

Carmeliet E. (1992). Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. The Journal of pharmacology and experimental therapeutics. 262 [PubMed]

Chinn K. (1993). Two delayed rectifiers in guinea pig ventricular myocytes distinguished by tail current kinetics. The Journal of pharmacology and experimental therapeutics. 264 [PubMed]

Colatsky TJ, Follmer CH, Lodge NJ, Mao H. (1990). Modulation of the delayed rectifier, IK, by cadmium in cat ventricular myocytes Biophys J. 57

Courtney KR, Hill BC, Follmer CH. (1992). The importance of K+ channel rectification to cardiac repolarization. Proceedings of the Western Pharmacology Society. 35 [PubMed]

Droogmans G, Nilius B. (1989). Kinetic properties of the cardiac T-type calcium channel in the guinea-pig. The Journal of physiology. 419 [PubMed]

Follmer CH, Colatsky TJ. (1990). Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes. Circulation. 82 [PubMed]

Franz MR, Schaefer J, Schöttler M, Seed WA, Noble MI. (1983). Electrical and mechanical restitution of the human heart at different rates of stimulation. Circulation research. 53 [PubMed]

Giles WR, Imaizumi Y. (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. The Journal of physiology. 405 [PubMed]

Girouard SD, Laurita KR, Rosenbaum DS. (1996). Unique properties of cardiac action potentials recorded with voltage-sensitive dyes. Journal of cardiovascular electrophysiology. 7 [PubMed]

Gwilt M et al. (1991). Electrophysiologic properties of UK-66,914, a novel class III antiarrhythmic agent. Journal of cardiovascular pharmacology. 17 [PubMed]

Hiraoka M, Singh B, Wellens H. (1994). Electropharmacological control of cardiac arrhythmias: to delay conductance or to prolong refractoriness.

Horie M, Hayashi S, Kawai C. (1990). Two types of delayed rectifying K+ channels in atrial cells of guinea pig heart. The Japanese journal of physiology. 40 [PubMed]

Iinuma H, Kato K. (1979). Mechanism of augmented premature responses in canine ventricular muscle. Circulation research. 44 [PubMed]

Jurkiewicz NK, Sanguinetti MC. (1993). Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circulation research. 72 [PubMed]

Kobayashi Y, Peters W, Khan SS, Mandel WJ, Karagueuzian HS. (1992). Cellular mechanisms of differential action potential duration restitution in canine ventricular muscle cells during single versus double premature stimuli. Circulation. 86 [PubMed]

Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Martin CL, Chinn K. (1992). Contribution of delayed rectifier and inward rectifier to repolarization of the action potential: pharmacologic separation. Journal of cardiovascular pharmacology. 19 [PubMed]

Matsuura H, Ehara T, Imoto Y. (1987). An analysis of the delayed outward current in single ventricular cells of the guinea-pig. Pflugers Archiv : European journal of physiology. 410 [PubMed]

Morgan JM, Cunningham D, Rowland E. (1992). Dispersion of monophasic action potential duration: demonstrable in humans after premature ventricular extrastimulation but not in steady state. Journal of the American College of Cardiology. 19 [PubMed]

Morgan JM, Cunningham D, Rowland E. (1992). Electrical restitution in the endocardium of the intact human right ventricle. British heart journal. 67 [PubMed]

Roberds SL, Tamkun MM. (1991). Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. Proceedings of the National Academy of Sciences of the United States of America. 88 [PubMed]

Robinson RB, Boyden PA, Hoffman BF, Hewett KW. (1987). Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. The American journal of physiology. 253 [PubMed]

Sakmann B, Trube G. (1984). Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. The Journal of physiology. 347 [PubMed]

Sanguinetti MC, Jurkiewicz NK. (1990). Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. The Journal of general physiology. 96 [PubMed]

Sanguinetti MC, Jurkiewicz NK. (1991). Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells. The American journal of physiology. 260 [PubMed]

Sanguinetti MC, Jurkiewicz NK. (1992). Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents. Pflugers Archiv : European journal of physiology. 420 [PubMed]

Shibasaki T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. The Journal of physiology. 387 [PubMed]

Snyders DJ, Tamkun MM, Bennett PB. (1993). A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. The Journal of general physiology. 101 [PubMed]

Tande PM, Bjørnstad H, Yang T, Refsum H. (1990). Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium. Journal of cardiovascular pharmacology. 16 [PubMed]

Todt H, Zojer N, Schütz W. (1994). Differential effect of dofetilide on ventricular repolarization during steady state and during restitution in vivo. Journal of cardiovascular pharmacology. 24 [PubMed]

Tohse N. (1990). Calcium-sensitive delayed rectifier potassium current in guinea pig ventricular cells. The American journal of physiology. 258 [PubMed]

Turgeon J et al. (1994). Block of IKs, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes. Circulation research. 75 [PubMed]

Veldkamp MW, van Ginneken AC, Bouman LN. (1993). Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circulation research. 72 [PubMed]

Walsh KB, Arena JP, Kwok WM, Freeman L, Kass RS. (1991). Delayed-rectifier potassium channel activity in isolated membrane patches of guinea pig ventricular myocytes. The American journal of physiology. 260 [PubMed]

Wang Z, Fermini B, Nattel S. (1993). Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents. Circulation research. 73 [PubMed]

Wang Z, Fermini B, Nattel S. (1993). Delayed rectifier outward current and repolarization in human atrial myocytes. Circulation research. 73 [PubMed]

Watanabe M, Otani NF, Gilmour RF. (1995). Biphasic restitution of action potential duration and complex dynamics in ventricular myocardium. Circulation research. 76 [PubMed]

Wong W et al. (1992). Pharmacology of the class III antiarrhythmic agent sematilide in patients with arrhythmias. The American journal of cardiology. 69 [PubMed]

Yang T et al. (1994). K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circulation research. 75 [PubMed]

Yue DT, Marban E. (1988). A novel cardiac potassium channel that is active and conductive at depolarized potentials. Pflugers Archiv : European journal of physiology. 413 [PubMed]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Courtemanche M, Ramirez RJ, Nattel S. (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. The American journal of physiology. 275 [PubMed]

• Cardiac Atrial Cell (Courtemanche et al 1998) [Model]
• Cardiac Atrial Cell (Courtemanche et al 1998) (C++) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Puglisi JL, Bers DM. (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American journal of physiology. Cell physiology. 281 [PubMed]

• A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research. 35 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• Simulation study of Andersen-Tawil syndrome (Sung et al 2006) [Model]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circulation research. 84 [PubMed]

• Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Wu SN. (2004). Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets. The Chinese journal of physiology. 47 [PubMed]

• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Armstrong D, Eckert R. (1987). Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization. Proceedings of the National Academy of Sciences of the United States of America. 84 [PubMed]

Bailie DS, Inoue H, Kaseda S, Ben-David J, Zipes DP. (1988). Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs. Circulation. 77 [PubMed]

Bean BP. (1984). Beta-adrenergic regulation of cardiac calcium channels: ionic current and gating current Biophys J (abstr). 57

Bean BP. (1985). Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. The Journal of general physiology. 86 [PubMed]

Cleemann L, Morad M. (1991). Role of Ca2+ channel in cardiac excitation-contraction coupling in the rat: evidence from Ca2+ transients and contraction. The Journal of physiology. 432 [PubMed]

Cranefield PF, Aronson RS. (1988). Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms.

Damiano BP, Rosen MR. (1984). Effects of pacing on triggered activity induced by early afterdepolarizations. Circulation. 69 [PubMed]

Duchatelle-Gourdon I, Hartzell HC, Lagrutta AA. (1989). Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium. The Journal of physiology. 415 [PubMed]

Désilets M, Baumgarten CM. (1986). Isoproterenol directly stimulates the Na+-K+ pump in isolated cardiac myocytes. The American journal of physiology. 251 [PubMed]

Fabiato A. (1983). Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. The American journal of physiology. 245 [PubMed]

Fabiato A. (1985). Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. The Journal of general physiology. 85 [PubMed]

Franckowiak G, Bechem M, Schramm M, Thomas G. (1985). The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. European journal of pharmacology. 114 [PubMed]

Gadsby DC. (2004). Beta-adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres. Nature. 306

Gao J, Mathias RT, Cohen IS, Baldo GJ. (1992). Isoprenaline, Ca2+ and the Na(+)-K+ pump in guinea-pig ventricular myocytes. The Journal of physiology. 449 [PubMed]

Gasser J, Paganetti P, Carafoli E, Chiesi M. (1988). Heterogeneous distribution of calmodulin- and cAMP-dependent regulation of Ca2+ uptake in cardiac sarcoplasmic reticulum subfractions. European journal of biochemistry. 176 [PubMed]

Giles W, Nakajima T, Ono K, Shibata EF. (1989). Modulation of the delayed rectifier K+ current by isoprenaline in bull-frog atrial myocytes. The Journal of physiology. 415 [PubMed]

Grouselle M, Stuyvers B, Bonoron-Adele S, Besse P, Georgescauld D. (1991). Digital-imaging microscopy analysis of calcium release from sarcoplasmic reticulum in single rat cardiac myocytes. Pflugers Archiv : European journal of physiology. 418 [PubMed]

Hadley RW, Lederer WJ. (1991). Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes. The Journal of general physiology. 98 [PubMed]

Hadley RW, Lederer WJ. (1991). Ca2+ and voltage inactivate Ca2+ channels in guinea-pig ventricular myocytes through independent mechanisms. The Journal of physiology. 444 [PubMed]

Hadley RW, Lederer WJ. (1992). Comparison of the effects of BAY K 8644 on cardiac Ca2+ current and Ca2+ channel gating current. The American journal of physiology. 262 [PubMed]

Harrison SM, Bers DM. (1987). The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA. Biochimica et biophysica acta. 925 [PubMed]

Harvey RD, Ten Eick RE. (1989). Voltage-dependent block of cardiac inward-rectifying potassium current by monovalent cations. The Journal of general physiology. 94 [PubMed]

Hirano Y, Moscucci A, January CT. (1992). Direct measurement of L-type Ca2+ window current in heart cells. Circulation research. 70 [PubMed]

Isenberg G. (1976). Cardiac Purkinje fibers: cesium as a tool to block inward rectifying potassium currents. Pflugers Archiv : European journal of physiology. 365 [PubMed]

January CT, Chau V, Makielski JC. (1991). Triggered activity in the heart: cellular mechanisms of early after-depolarizations. European heart journal. 12 Suppl F [PubMed]

January CT, Moscucci A. (1992). Cellular mechanisms of early afterdepolarizations. Annals of the New York Academy of Sciences. 644 [PubMed]

January CT, Riddle JM. (1989). Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circulation research. 64 [PubMed]

January CT, Riddle JM, Salata JJ. (1988). A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644. Circulation research. 62 [PubMed]

Kameyama M, Hescheler J, Hofmann F, Trautwein W. (1986). Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflugers Archiv : European journal of physiology. 407 [PubMed]

Kass RS. (1987). Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: implications for channel gating. Circulation research. 61 [PubMed]

Kimura S, Bassett AL, Xi H, Myerburg RJ. (1992). Early afterdepolarizations and triggered activity induced by cocaine. A possible mechanism of cocaine arrhythmogenesis. Circulation. 85 [PubMed]

Kurihara S, Konishi M. (1987). Effects of beta-adrenoceptor stimulation on intracellular Ca transients and tension in rat ventricular muscle. Pflugers Archiv : European journal of physiology. 409 [PubMed]

Le Peuch CJ, Demaille JG. (2005). Covalent regulation of the cardiac sarcoplasmic reticulum calcium pump. Review article. Cell Calcium. 10

Leblanc N, Hume JR. (1990). Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science (New York, N.Y.). 248 [PubMed]

Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Marban E, Robinson SW, Wier WG. (1986). Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. The Journal of clinical investigation. 78 [PubMed]

Markwardt F, Nilius B. (1988). Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644. The Journal of physiology. 399 [PubMed]

Meier CF, Katzung BG. (1981). Cesium blockade of delayed outward currents and electrically induced pacemaker activity in mammalian ventricular myocardium. The Journal of general physiology. 77 [PubMed]

Nattel S, Quantz MA. (1988). Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovascular research. 22 [PubMed]

Nunoki K, Florio V, Catterall WA. (1989). Activation of purified calcium channels by stoichiometric protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 86 [PubMed]

Ochi R, Kawashima Y. (1990). Modulation of slow gating process of calcium channels by isoprenaline in guinea-pig ventricular cells. The Journal of physiology. 424 [PubMed]

Okazaki O, Suda N, Hongo K, Konishi M, Kurihara S. (1990). Modulation of Ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. The Journal of physiology. 423 [PubMed]

Ono K, Kiyosue T, Arita M. (1989). Isoproterenol, DBcAMP, and forskolin inhibit cardiac sodium current. The American journal of physiology. 256 [PubMed]

Ono K, Trautwein W. (1991). Potentiation by cyclic GMP of beta-adrenergic effect on Ca2+ current in guinea-pig ventricular cells. The Journal of physiology. 443 [PubMed]

Priori SG, Corr PB. (1990). Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. The American journal of physiology. 258 [PubMed]

Rasmusson RL, Clark JW, Giles WR, Shibata EF, Campbell DL. (1990). A mathematical model of a bullfrog cardiac pacemaker cell. The American journal of physiology. 259 [PubMed]

Rosen MR. (1990). The concept of afterdepolarization Cardiac Electrophysiology: A Textbook.

Rosen MR, Janse MJ, Wit AL. (1990). Cardiac Electrophysiology:A Textbook.

Sanguinetti MC, Krafte DS, Kass RS. (1986). Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644. The Journal of general physiology. 88 [PubMed]

Sawanobori T, Hiraoka M, Zheng F, Sunami A. (1992). Multiple ionic mechanisms of early afterdepolarizations in isolated ventricular myocytes from guinea-pig hearts. QT Prolongations and Ventricular Arrhythmias.

Shorofsky SR, January CT. (1992). L- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current. Circulation research. 70 [PubMed]

Standen NB, Stanfield PR. (1982). A binding-site model for calcium channel inactivation that depends on calcium entry. Proceedings of the Royal Society of London. Series B, Biological sciences. 217 [PubMed]

Stern MD, Capogrossi MC, Lakatta EG. (1988). Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell calcium. 9 [PubMed]

Szabo G, Otero AS. (1990). G protein mediated regulation of K+ channels in heart. Annual review of physiology. 52 [PubMed]

Tiaho F, Nargeot J, Richard S. (1991). Voltage-dependent regulation of L-type cardiac Ca channels by isoproterenol. Pflugers Archiv : European journal of physiology. 419 [PubMed]

Tiaho F, Richard S, Lory P, Nerbonne JM, Nargeot J. (1990). Cyclic-AMP-dependent phosphorylation modulates the stereospecific activation of cardiac Ca channels by Bay K 8644. Pflugers Archiv : European journal of physiology. 417 [PubMed]

Tourneur Y, Mitra R, Morad M, Rougier O. (1987). Activation properties of the inward-rectifying potassium channel on mammalian heart cells. The Journal of membrane biology. 97 [PubMed]

Trautwein W, Cavalié A, Flockerzi V, Hofmann F, Pelzer D. (1987). Modulation of calcium channel function by phosphorylation in guinea pig ventricular cells and phospholipid bilayer membranes. Circulation research. 61 [PubMed]

Tseng GN, Robinson RB, Hoffman BF. (1987). Passive properties and membrane currents of canine ventricular myocytes. The Journal of general physiology. 90 [PubMed]

Tsien RW et al. (1986). Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. Journal of molecular and cellular cardiology. 18 [PubMed]

Tsien RW, Bean BP, Nowycky MC. (2004). Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature. 307

Tsien RW, Giles W, Greengard P. (1972). Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nature: New biology. 240 [PubMed]

Tsien RW, Hess P, Lansman JB. (2004). Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature. 311

Tytgat J, Nilius B, Vereecke J, Carmeliet E. (1988). The T-type Ca channel in guinea-pig ventricular myocytes is insensitive to isoproterenol. Pflugers Archiv : European journal of physiology. 411 [PubMed]

Walsh KB, Begenisich TB, Kass RS. (1988). Beta-adrenergic modulation in the heart. Independent regulation of K and Ca channels. Pflugers Archiv : European journal of physiology. 411 [PubMed]

Walsh KB, Begenisich TB, Kass RS. (1989). Beta-adrenergic modulation of cardiac ion channels. Differential temperature sensitivity of potassium and calcium currents. The Journal of general physiology. 93 [PubMed]

Wier WG, Takamatsu T. (2004). High temporal resolution video imaging of intracellular calcium. Cell Calcium. 11

Zeng J, Rudy Y. (1994). Simulation studies of the mechanism of arrhythmogenic early afterdepolarizations in cardiac myocytes Biophys J (Abstr). 66

Zeng J, Rudy Y. (1994). Simulation studies of the rate dependence mechanism of early and delayed afterdepolarizations FASEB J. 6

Zipes DP, Kadesa S. (1990). Effects of alpha adrenoceptor stimulation and blockade on early afterdepolarizations induced by cesium in canine cardiac Purkinje fibers J Cardiovasc Electrophysiol. 1

el-Sherif N, Boutjdir M. (1991). Pharmacological evaluation of early afterdepolarisations induced by sea anemone toxin (ATXII) in dog heart. Cardiovasc Res. 25

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Courtemanche M, Ramirez RJ, Nattel S. (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. The American journal of physiology. 275 [PubMed]

• Cardiac Atrial Cell (Courtemanche et al 1998) [Model]
• Cardiac Atrial Cell (Courtemanche et al 1998) (C++) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Silva J, Rudy Y. (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112 [PubMed]

• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) [Model]
• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP) [Model]

Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. (2005). The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophysical journal. 88 [PubMed]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Abete P, Vassalle M. (1988). Relation between Na+-K+ pump, Na+ activity and force in strophanthidin inotropy in sheep cardiac Purkinje fibres. The Journal of physiology. 404 [PubMed]

Backx PH, de Tombe PP, Van Deen JH, Mulder BJ, ter Keurs HE. (1989). A model of propagating calcium-induced calcium release mediated by calcium diffusion. The Journal of general physiology. 93 [PubMed]

Bassingthwaighte JB, Fabiato A, Wong AYK. (1987). Model of Carelease mechanism from the sarcoplasmic reticulum: Camediated activation, inactivation and reactivation Activation, Metabolism and Perfusion of the Heart.

Beeler GW, Reuter H. (1977). Reconstruction of the action potential of ventricular myocardial fibres. The Journal of physiology. 268 [PubMed]

• Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Beuckelmann DJ, Wier WG. (1988). Mechanism of release of calcium from sarcoplasmic reticulum of guinea-pig cardiac cells. The Journal of physiology. 405 [PubMed]

Beuckelmann DJ, Wier WG. (1989). Sodium-calcium exchange in guinea-pig cardiac cells: exchange current and changes in intracellular Ca2+. The Journal of physiology. 414 [PubMed]

Blatter LA, McGuigan JA, Reverdin EC. (1986). Sodium/calcium exchange and calcium buffering in mammalian ventricular muscle. Japanese heart journal. 27 Suppl 1 [PubMed]

Bridge JH, Smolley JR, Spitzer KW. (1990). The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science (New York, N.Y.). 248 [PubMed]

Campbell DL, Giles WR, Hume JR, Shibata EF. (1988). Inactivation of calcium current in bull-frog atrial myocytes. The Journal of physiology. 403 [PubMed]

Campbell DL, Giles WR, Robinson K, Shibata EF. (1988). Studies of the sodium-calcium exchanger in bull-frog atrial myocytes. The Journal of physiology. 403 [PubMed]

Campbell DL, Giles WR, Shibata EF. (1988). Ion transfer characteristics of the calcium current in bull-frog atrial myocytes. The Journal of physiology. 403 [PubMed]

Cannell MB, Allen DG. (1984). Model of calcium movements during activation in the sarcomere of frog skeletal muscle. Biophysical journal. 45 [PubMed]

Cannell MB, Berlin JR, Lederer WJ. (1987). Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells. Science (New York, N.Y.). 238 [PubMed]

Cannell MB, Lederer WJ. (1986). The arrhythmogenic current ITI in the absence of electrogenic sodium-calcium exchange in sheep cardiac Purkinje fibres. The Journal of physiology. 374 [PubMed]

Capogrossi MC, Stern MD, Spurgeon HA, Lakatta EG. (1988). Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium. The Journal of general physiology. 91 [PubMed]

Caroni P, Zurini M, Clark A, Carafoli E. (1983). Further characterization and reconstitution of the purified Ca2+-pumping ATPase of heart sarcolemma. The Journal of biological chemistry. 258 [PubMed]

Cavalié A, McDonald TF, Pelzer D, Trautwein W. (1985). Temperature-induced transitory and steady-state changes in the calcium current of guinea pig ventricular myocytes. Pflugers Archiv : European journal of physiology. 405 [PubMed]

Chamberlain BK, Volpe P, Fleischer S. (1984). Calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles. General characteristics. The Journal of biological chemistry. 259 [PubMed]

Cohen IS, Datyner NB, Gintant GA, Mulrine NK, Pennefather P. (1987). Properties of an electrogenic sodium-potassium pump in isolated canine Purkinje myocytes. The Journal of physiology. 383 [PubMed]

Cohen IS, Kline RP, Pennefather P, Mulrine NK. (1987). Models of the Na-K pump in cardiac muscle predict the wrong intracellular Na+ activity. Proceedings of the Royal Society of London. Series B, Biological sciences. 231 [PubMed]

Cohen IS, Mathias RT, Datyner NB, Eisenberg B. (1985). Impedance and morphology of isolated canine cardiac Purkinje myocytes: comparison with intact strand preparations Biophys J. 47

Coronado R, Lee CJ, Kawano S. (1990). Ca2+ dependent activation andinactivation of Ca 2+ release channels in the sarcoplasmic reticulum of cardiac and skeletal muscle J Moll Cell Cardiol. 22

Daut J. (1983). Inhibition of the sodium pump in guinea-pig ventricular muscle by dihydro-ouabain: effects of external potassium and sodium. The Journal of physiology. 339 [PubMed]

Daut J. (1986). The energetics of the Na, K-pump in cardiac muscle. Membrane Control. 338

Daut J, Rüdel R. (1982). The electrogenic sodium pump in guinea-pig ventricular muscle: inhibition of pump current by cardiac glycosides. The Journal of physiology. 330 [PubMed]

Dennis JE, Gay DM, Welsch RE. (1981). An adaptive nonlinear leastsquares algorithm ACM Transactions On Mathematical Software. 7

DiFrancesco D, Noble D. (1985). A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 307 [PubMed]

• Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985) [Model]

Doerr T, Denger R, Doerr A, Trautwein W. (1990). Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Droogmans G, Nilius B. (1989). Kinetic properties of the cardiac T-type calcium channel in the guinea-pig. The Journal of physiology. 419 [PubMed]

Drouhard JP, Roberge FA. (1987). Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells. Computers and biomedical research, an international journal. 20 [PubMed]

Ebihara L, Johnson EA. (1980). Fast sodium current in cardiac muscle. A quantitative description. Biophysical journal. 32 [PubMed]

Ehara T, Matsuoka S, Noma A. (1989). Measurement of reversal potential of Na+-Ca2+ exchange current in single guinea-pig ventricular cells. The Journal of physiology. 410 [PubMed]

Ehara T, Noma A, Ono K. (1988). Calcium-activated non-selective cation channel in ventricular cells isolated from adult guinea-pig hearts. The Journal of physiology. 403 [PubMed]

Fabiato A. (1985). Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell. The Journal of general physiology. 85 [PubMed]

Fabiato A. (1985). Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. The Journal of general physiology. 85 [PubMed]

Fabiato A. (1985). Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. The Journal of general physiology. 85 [PubMed]

Gadsby DC. (1990). The Na K pump of cardiac myocytes Cardiac Electrophysiology-From Cell to Bedside.

Gadsby DC, Nakao M. (1989). Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes. The Journal of general physiology. 94 [PubMed]

Gerdes AM, Kasten FH. (1980). Morphometric study of endomyocardium and epimyocardium of the left ventricle in adult dogs. The American journal of anatomy. 159 [PubMed]

Gettes LS, Reuter H. (1974). Slow recovery from inactivation of inward currents in mammalian myocardial fibres. The Journal of physiology. 240 [PubMed]

Giles W, Shimoni Y. (1989). Comparison of sodium-calcium exchanger and transient inward currents in single cells from rabbit ventricle. The Journal of physiology. 417 [PubMed]

Giles WR, Imaizumi Y. (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. The Journal of physiology. 405 [PubMed]

Giles WR, Noble D, Shibata EF, Campbell DL, Hume JR. (1988). Reversal potential of the calcium current in bull-frog atrial myocytes. J Physiol. 403

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

• Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
• Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]
• Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]

Hadley RW, Hume JR. (1987). An intrinsic potential-dependent inactivation mechanism associated with calcium channels in guinea-pig myocytes. The Journal of physiology. 389 [PubMed]

Harvey RD, Clark CD, Hume JR. (1990). Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential. The Journal of general physiology. 95 [PubMed]

Haynes DH, Mandveno A. (1987). Computer modeling of Ca2+ pump function of Ca2+-Mg2+-ATPase of sarcoplasmic reticulum. Physiological reviews. 67 [PubMed]

Hess P, Lansman JB, Tsien RW. (1986). Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. The Journal of general physiology. 88 [PubMed]

Hilgemann DW, Noble D. (1987). Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Proceedings of the Royal Society of London. Series B, Biological sciences. 230 [PubMed]

Horie M, Irisawa H, Noma A. (1987). Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. The Journal of physiology. 387 [PubMed]

Hume JR, Uehara A. (1985). Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. The Journal of physiology. 368 [PubMed]

Inui M, Wang S, Saito A, Fleischer S. (1988). Characterization of junctional and longitudinal sarcoplasmic reticulum from heart muscle. The Journal of biological chemistry. 263 [PubMed]

Jorgensen AO, Broderick R, Somlyo AP, Somlyo AV. (1988). Two structurally distinct calcium storage sites in rat cardiac sarcoplasmic reticulum: an electron microprobe analysis study. Circulation research. 63 [PubMed]

Josephson IR, Sanchez-Chapula J, Brown AM. (1984). A comparison of calcium currents in rat and guinea pig single ventricular cells. Circulation research. 54 [PubMed]

Kamp TJ, Sanguinetti MC, Miller RJ. (1989). Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circulation research. 64 [PubMed]

Kass RS, Sanguinetti MC. (1984). Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms. The Journal of general physiology. 84 [PubMed]

Kimura J, Miyamae S, Noma A. (1987). Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig. The Journal of physiology. 384 [PubMed]

Klockner U, Isenberg G. (1982). Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium". Pflugers Arch. 395

Lagnado L, McNaughton PA. (1990). Electrogenic properties of the Na:Ca exchange. The Journal of membrane biology. 113 [PubMed]

Leblanc N, Hume JR. (1990). Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science (New York, N.Y.). 248 [PubMed]

Lee KS, Marban E, Tsien RW. (1985). Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. The Journal of physiology. 364 [PubMed]

Lipp P, Pott L. (1988). Transient inward current in guinea-pig atrial myocytes reflects a change of sodium-calcium exchange current. The Journal of physiology. 397 [PubMed]

Luk HN, Carmeliet E. (1990). Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Malécot CO, Trautwein W. (1987). On the relationship between V max of slow responses and Ca-current availability in whole-cell clamped guinea pig heart cells. Pflugers Archiv : European journal of physiology. 410 [PubMed]

Markwardt F, Nilius B. (1988). Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644. The Journal of physiology. 399 [PubMed]

Matsuura H, Ehara T, Imoto Y. (1987). An analysis of the delayed outward current in single ventricular cells of the guinea-pig. Pflugers Archiv : European journal of physiology. 410 [PubMed]

McDonald TF, Cavalié A, Trautwein W, Pelzer D. (1986). Voltage-dependent properties of macroscopic and elementary calcium channel currents in guinea pig ventricular myocytes. Pflugers Archiv : European journal of physiology. 406 [PubMed]

Meissner G, Henderson JS. (1987). Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin. The Journal of biological chemistry. 262 [PubMed]

Mogul DJ, Singer DH, Ten Eick RE. (1990). Dependence of Na-K pump current on internal Na+ in mammalian cardiac myocytes. The American journal of physiology. 259 [PubMed]

Mulder BJ, de Tombe PP, ter Keurs HE. (1989). Spontaneous and propagated contractions in rat cardiac trabeculae. The Journal of general physiology. 93 [PubMed]

Mullins LJ. (1977). A mechanism for Na/Ca transport. The Journal of general physiology. 70 [PubMed]

Nakao M, Gadsby DC. (1989). [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. The Journal of general physiology. 94 [PubMed]

Priori SG, Corr PB. (1990). Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. The American journal of physiology. 258 [PubMed]

Quan W, Rudy Y. (1990). Unidirectional block and reentry of cardiac excitation: a model study. Circulation research. 66 [PubMed]

Rardon DP, Cefali DC, Mitchell RD, Seiler SM, Jones LR. (1989). High molecular weight proteins purified from cardiac junctional sarcoplasmic reticulum vesicles are ryanodine-sensitive calcium channels. Circulation research. 64 [PubMed]

Rasmusson RL et al. (1990). A mathematical model of electrophysiological activity in a bullfrog atrial cell. The American journal of physiology. 259 [PubMed]

Robertson SP, Johnson JD, Potter JD. (1981). The time-course of Ca2+ exchange with calmodulin, troponin, parvalbumin, and myosin in response to transient increases in Ca2+. Biophysical journal. 34 [PubMed]

Robinson RB, Boyden PA, Hoffman BF, Hewett KW. (1987). Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. The American journal of physiology. 253 [PubMed]

Rudy Y, Quan W. (1991). Propagation delays across gap junctions andtheir reflection in extracellular potentials: a simulation study J Cardiovasc Electrophysiol. 2

Rudy Y, Quan WL. (1987). A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circulation research. 61 [PubMed]

Rush S, Larsen H. (1978). A practical algorithm for solving dynamic membrane equations. IEEE transactions on bio-medical engineering. 25 [PubMed]

Sakmann B, Trube G. (1984). Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. The Journal of physiology. 347 [PubMed]

Sanguinetti MC, Jurkiewicz NK. (1991). Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells. The American journal of physiology. 260 [PubMed]

Schaper J, Meiser E, Stämmler G. (1985). Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts. Circulation research. 56 [PubMed]

Sejersted OM, Wasserstrom JA, Fozzard HA. (1988). Na,K pump stimulation by intracellular Na in isolated, intact sheep cardiac Purkinje fibers. The Journal of general physiology. 91 [PubMed]

Severs NJ, Slade AM, Powell T, Twist VW, Jones GE. (1985). Morphometric analysis of the isolated calcium-tolerant cardiac myocyte. Organelle volumes, sarcomere length, plasma membrane surface folds, and intramembrane particle density and distribution. Cell and tissue research. 240 [PubMed]

Sheu SS, Fozzard HA. (1982). Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. The Journal of general physiology. 80 [PubMed]

Sperelakis N, Forbes MS. (1989). Ultrastructure of mammalian cardiacmuscle Physiology and Pathophysiology of the Heart. 2nd ed.

Sperelakis N, Forbes MS, Hawkey LA, Jirge SK. (2004). The sarcoplasmic reticulum of mouse heart: its divisions, configurations, and distribution. J Ultrastruct Res. 93

Standen NB, Stanfield PR. (1982). A binding-site model for calcium channel inactivation that depends on calcium entry. Proceedings of the Royal Society of London. Series B, Biological sciences. 217 [PubMed]

Stern MD, Capogrossi MC, Lakatta EG. (1988). Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell calcium. 9 [PubMed]

Stimers JR, Shigeto N, Lieberman M. (1990). Na/K pump current in aggregates of cultured chick cardiac myocytes. The Journal of general physiology. 95 [PubMed]

Tada M, Shigekawa M, Kadoma M, Nimura Y. (1989). Uptake of calciumby sarcoplasmic reticulum and its regulation and functional consequences Physiology and Pathophysiology of the Heart. 2nd ed.

Takamatsu T, Wier WG. (1990). Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 4 [PubMed]

Tohse N. (1990). Calcium-sensitive delayed rectifier potassium current in guinea pig ventricular cells. The American journal of physiology. 258 [PubMed]

Trautwein W, Cavalie A, Pelzer D, Mcdonald TF. (1989). Calcium channels in single heart cells Isolated Adult Cardiomyocytes. 2

Victorri B, Vinet A, Roberge FA, Drouhard JP. (1985). Numerical integration in the reconstruction of cardiac action potentials using Hodgkin-Huxley-type models. Computers and biomedical research, an international journal. 18 [PubMed]

Weidmann S. (1970). Electrical constants of trabecular muscle from mammalian heart. The Journal of physiology. 210 [PubMed]

Wier WG, Beuckelmann DJ. (1989). Sodium-calcium exchange in mammalian heart: current-voltage relation and intracellular calcium concentration. Molecular and cellular biochemistry. 89 [PubMed]

Wier WG, Yue DT. (1986). Intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. The Journal of physiology. 376 [PubMed]

Yasui K, Kimura J. (1990). Is potassium co-transported by the cardiac Na-Ca exchange? Pflugers Archiv : European journal of physiology. 415 [PubMed]

Yue DT, Backx PH, Imredy JP. (1990). Calcium-sensitive inactivation in the gating of single calcium channels. Science (New York, N.Y.). 250 [PubMed]

Yue DT, Burkhoff D, Franz MR, Hunter WC, Sagawa K. (1985). Postextrasystolic potentiation of the isolated canine left ventricle. Relationship to mechanical restitution. Circulation research. 56 [PubMed]

Bartocci E, Corradini F, Entcheva E, Smolka SA, Grosu R. (2008). CellExcite: an efficient simulation environment for excitable cells BMC Bioinformatics. 9(Suppl 2)

• CellExcite: an efficient simulation environment for excitable cells (Bartocci et al. 2008) [Model]

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

• Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004) [Model]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B. (2003). An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophysical journal. 84 [PubMed]

• Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006) [Model]

Courtemanche M, Ramirez RJ, Nattel S. (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. The American journal of physiology. 275 [PubMed]

• Cardiac Atrial Cell (Courtemanche et al 1998) [Model]
• Cardiac Atrial Cell (Courtemanche et al 1998) (C++) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Fardet T, Levina A. (2020). Simple Models Including Energy and Spike Constraints Reproduce Complex Activity Patterns and Metabolic Disruptions PLoS computational biology. 16 [PubMed]

• eLIF and mAdExp: energy-based integrate-and-fire neurons (Fardet and Levina 2020) [Model]

Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006) [Model]

Fox JJ, McHarg JL, Gilmour RF. (2002). Ionic mechanism of electrical alternans. American journal of physiology. Heart and circulatory physiology. 282 [PubMed]

• Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007) [Model]

Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]

• Excitation-contraction coupling in an integrative heart cell model (Greenstein et al 2006) [Model]

Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]

Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL. (2000). Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circulation research. 87 [PubMed]

• Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP) [Model]
• Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004). A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophysical journal. 87 [PubMed]

Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]

• A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004) [Model]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]

Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A. (2003). Role of individual ionic current systems in ventricular cells hypothesized by a model study. The Japanese journal of physiology. 53 [PubMed]

• Markovian model for single-channel recordings of Ik_1 in ventricular cells (Matsuoka et al 2003) [Model]

Puglisi JL, Bers DM. (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American journal of physiology. Cell physiology. 281 [PubMed]

• A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research. 35 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Song W et al. (2012). The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity. The Journal of physiology. 590 [PubMed]

Splawski I et al. (2005). Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences of the United States of America. 102 [PubMed]

Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• Simulation study of Andersen-Tawil syndrome (Sung et al 2006) [Model]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Wang YJ, Sung RJ, Lin MW, Wu SN. (2006). Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. The Journal of membrane biology. 213 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Willms AR. (2002). NEUROFIT: software for fitting Hodgkin-Huxley models to voltage-clamp data. Journal of neuroscience methods. 121 [PubMed]

• NEUROFIT: fitting HH models to voltage clamp data (Willms 2002) [Model]

Winslow RL, Cortassa S, Greenstein JL. (2005). Using models of the myocyte for functional interpretation of cardiac proteomic data. The Journal of physiology. 563 [PubMed]

Winslow RL, Greenstein JL. (2004). The ongoing journey to understand heart function through integrative modeling. Circulation research. 95 [PubMed]

Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circulation research. 84 [PubMed]

• Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Wu SN. (2004). Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets. The Chinese journal of physiology. 47 [PubMed]

• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zhu ZI, Clancy CE. (2007). L-type Ca2+ channel mutations and T-wave alternans: a model study. American journal of physiology. Heart and circulatory physiology. 293 [PubMed]

• Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007) [Model]

Østby I et al. (2009). Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS computational biology. 5 [PubMed]

• Mechanisms of extraneuronal space shrinkage (Ostby et al 2009) [Model]

Antzelevitch C, Eddlestone GT, Zygmont AC. (1996). Larger late sodium current contributes to the longer action potential of the M-cell in canine ventricular myocardium PACE. 19

Antzelevitch C, Sicouri S. (1993). Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis. J Cardiovasc Electrophysiol. 4

Anyukhovsky EP, Sosunov EA, Rosen MR. (1996). Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium. In vitro and in vivo correlations. Circulation. 94 [PubMed]

Brahmajothi MV, Morales MJ, Reimer KA, Strauss HC. (1997). Regional localization of ERG, the channel protein responsible for the rapid component of the delayed rectifier, K+ current in the ferret heart. Circulation research. 81 [PubMed]

Cannell MB, Cheng H, Lederer WJ. (1995). The control of calcium release in heart muscle. Science (New York, N.Y.). 268 [PubMed]

Cohen CJ, Fozzard HA, Sheu SS. (1982). Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circulation research. 50 [PubMed]

Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. (1995). Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. Journal of the American College of Cardiology. 26 [PubMed]

Duggal P et al. (1998). Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome. Circulation. 97 [PubMed]

Harrison SM, Boyett MR. (1995). The role of the Na(+)-Ca2+ exchanger in the rate-dependent increase in contraction in guinea-pig ventricular myocytes. The Journal of physiology. 482 ( Pt 3) [PubMed]

January CT, Riddle JM. (1989). Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circulation research. 64 [PubMed]

Jurkiewicz NK, Sanguinetti MC. (1993). Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circulation research. 72 [PubMed]

Kieval RS, Spear JF, Moore EN. (1992). Gap junctional conductance in ventricular myocyte pairs isolated from postischemic rabbit myocardium. Circulation research. 71 [PubMed]

Litovsky SH, Antzelevitch C. (1989). Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. Journal of the American College of Cardiology. 14 [PubMed]

Liu DW, Antzelevitch C. (1995). Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circulation research. 76 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Nitta J, Furukawa T, Marumo F, Sawanobori T, Hiraoka M. (1994). Subcellular mechanism for Ca(2+)-dependent enhancement of delayed rectifier K+ current in isolated membrane patches of guinea pig ventricular myocytes. Circulation research. 74 [PubMed]

Rudy Y. (1995). Reentry: insights from theoretical simulations in a fixed pathway. Journal of cardiovascular electrophysiology. 6 [PubMed]

Salama G et al. (1998). Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations. Journal of cardiovascular electrophysiology. 9 [PubMed]

Sanguinetti MC, Curran ME, Spector PS, Keating MT. (1996). Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]

Sanguinetti MC, Jurkiewicz NK. (1990). Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. The Journal of general physiology. 96 [PubMed]

Shaw RM, Rudy Y. (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circulation research. 81 [PubMed]

Shimizu W, Antzelevitch C. (1997). Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation. 96 [PubMed]

Sicouri S, Antzelevitch C. (1991). A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circulation research. 68 [PubMed]

Sicouri S, Quist M, Antzelevitch C. (1996). Evidence for the presence of M cells in the guinea pig ventricle. Journal of cardiovascular electrophysiology. 7 [PubMed]

Surawicz B. (1989). Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations? Journal of the American College of Cardiology. 14 [PubMed]

Tohse N. (1990). Calcium-sensitive delayed rectifier potassium current in guinea pig ventricular cells. The American journal of physiology. 258 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

el-Sherif N, Caref EB, Yin H, Restivo M. (1996). The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circulation research. 79 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Diekman CO, Wei N. (2021). Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophysical journal. 120 [PubMed]

• Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]

• A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004) [Model]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Silva J, Rudy Y. (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112 [PubMed]

• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) [Model]
• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP) [Model]

Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• Simulation study of Andersen-Tawil syndrome (Sung et al 2006) [Model]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Adam DR et al. (1984). Fluctuations in T-wave morphology and susceptibility to ventricular fibrillation. Journal of electrocardiology. 17 [PubMed]

Beeler GW, Reuter H. (1977). Reconstruction of the action potential of ventricular myocardial fibres. The Journal of physiology. 268 [PubMed]

• Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Berman MF, Camardo JS, Robinson RB, Siegelbaum SA. (1989). Single sodium channels from canine ventricular myocytes: voltage dependence and relative rates of activation and inactivation. The Journal of physiology. 415 [PubMed]

Bodewei R et al. (1982). Characterization of the fast sodium current in isolated rat myocardial cells: simulation of the clamped membrane potential. The Journal of physiology. 325 [PubMed]

Brown AM, Lee KS, Powell T. (1981). Sodium current in single rat heart muscle cells. The Journal of physiology. 318 [PubMed]

Chialvo DR, Michaels DC, Jalife J. (1990). Supernormal excitability as a mechanism of chaotic dynamics of activation in cardiac Purkinje fibers. Circulation research. 66 [PubMed]

Chiu SY. (1977). Inactivation of sodium channels: second order kinetics in myelinated nerve. The Journal of physiology. 273 [PubMed]

Cleemann L, Morad M. (1979). Potassium currents in frog ventricular muscle: evidence from voltage clamp currents and extracellular K accumulation. The Journal of physiology. 286 [PubMed]

Colatsky TJ. (1980). Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres. The Journal of physiology. 305 [PubMed]

Coraboeuf E, Deroubaix E, Coulombe A. (1979). Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. The American journal of physiology. 236 [PubMed]

Delmar M, Glass L, Michaels DC, Jalife J. (1989). Ionic basis and analytical solution of the wenckebach phenomenon in guinea pig ventricular myocytes. Circulation research. 65 [PubMed]

Delmar M, Michaels DC, Jalife J. (1989). Slow recovery of excitability and the Wenckebach phenomenon in the single guinea pig ventricular myocyte. Circulation research. 65 [PubMed]

Dennis JE, Gay DM, Welsch RE. (1981). An adaptive nonlinear leastsquares algorithm ACM Transactions On Mathematical Software. 7

DiFrancesco D, Noble D. (1985). A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 307 [PubMed]

• Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985) [Model]

Drouhard JP, Roberge FA. (1987). Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells. Computers and biomedical research, an international journal. 20 [PubMed]

Ebihara L, Johnson EA. (1980). Fast sodium current in cardiac muscle. A quantitative description. Biophysical journal. 32 [PubMed]

Ebihara L, Shigeto N, Lieberman M, Johnson EA. (1980). The initial inward current in spherical clusters of chick embryonic heart cells. The Journal of general physiology. 75 [PubMed]

Ebihara L, Shigeto N, Lieberman M, Johnson EA. (1983). A note on the reactivation of the fast sodium current in spherical clusters of embryonic chick heart cells. Biophysical journal. 42 [PubMed]

Elharrar V, Surawicz B. (1983). Cycle length effect on restitution ofaction potential duration in dog cardiac fibers Am J Physiol. 244

Frame LH, Simson MB. (1988). Oscillations of conduction, action potential duration, and refractoriness. A mechanism for spontaneous termination of reentrant tachycardias. Circulation. 78 [PubMed]

French RJ, Horn R. (1983). Sodium channel gating: models, mimics, and modifiers. Annual review of biophysics and bioengineering. 12 [PubMed]

Gettes LS, Reuter H. (1974). Slow recovery from inactivation of inward currents in mammalian myocardial fibres. The Journal of physiology. 240 [PubMed]

Grant AO, Starmer CF. (1987). Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis. Circulation research. 60 [PubMed]

Guevara MR, Jeandupeux D, Alonso F, Morissette N. (1989). Wenckebach rhythms in isolated ventricular heart cells Singular Behavior and Nonlinear Dynamics. 2

Guevara MR, Jeandupeux D, Alonso F, Van_Ginneken ACG. (1989). Alternans in periodically stimulated isolated ventricular myocytes: Experiment and model Cell to Cell Signalling: From Experments to Theoretical Models.

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

• Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
• Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]
• Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]

Haas HG, Kern R, Einwächter HM, Tarr M. (1971). Kinetics of Na inactivation in frog atria. Pflugers Archiv : European journal of physiology. 323 [PubMed]

Hirano Y, Hiraoka M. (1986). Changes in K+ currents induced by Ba2+ in guinea pig ventricular muscles. The American journal of physiology. 251 [PubMed]

Hoff HE, Nahum LH. (1938). The supernormal period in the mammalian ventricle Am J Physiol. 124

Horn R, Vandenberg CA. (1984). Statistical properties of single sodium channels. The Journal of general physiology. 84 [PubMed]

Hume JR, Uehara A. (1985). Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. The Journal of physiology. 368 [PubMed]

Iijima T, Taira N. (1987). Pinacidil increases the background potassium current in single ventricular cells. European journal of pharmacology. 141 [PubMed]

Isenberg G. (1976). Cardiac Purkinje fibers: cesium as a tool to block inward rectifying potassium currents. Pflugers Archiv : European journal of physiology. 365 [PubMed]

Isenberg G, Klöckner U. (1982). Isolated bovine ventricular myocytes. Characterization of the action potential. Pflugers Archiv : European journal of physiology. 395 [PubMed]

Jalife J, Moe GK. (1981). Excitation, conduction, and reflection of impulses in isolated bovine and serum cardiac purkinje fibers. Circulation research. 49 [PubMed]

Kakei M, Yoshinaga M, Saito K, Tanaka H. (1986). The potassium current activated by 2-nicotinamidoethyl nitrate (nicorandil) in single ventricular cells of guinea pigs. Proceedings of the Royal Society of London. Series B, Biological sciences. 229 [PubMed]

Kamp TJ, Sanguinetti MC, Miller RJ. (1989). Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circulation research. 64 [PubMed]

Kirsch GE, Brown AM. (1989). Kinetic properties of single sodium channels in rat heart and rat brain. The Journal of general physiology. 93 [PubMed]

Kiyosue T, Arita M. (1989). Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circulation research. 64 [PubMed]

Klockner U, Isenberg G. (1982). Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium". Pflugers Arch. 395

Kunze DL, Lacerda AE, Wilson DL, Brown AM. (1985). Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels. The Journal of general physiology. 86 [PubMed]

Kurachi Y. (1985). Voltage-dependent activation of the inward-rectifier potassium channel in the ventricular cell membrane of guinea-pig heart. The Journal of physiology. 366 [PubMed]

Leblanc N, Hume JR. (1990). Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science (New York, N.Y.). 248 [PubMed]

Lesh MD, Pring M, Spear JF. (1989). Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study. Circulation research. 65 [PubMed]

Makielski JC, Sheets MF, Hanck DA, January CT, Fozzard HA. (1987). Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. Biophysical journal. 52 [PubMed]

Matsuura H, Ehara T, Imoto Y. (1987). An analysis of the delayed outward current in single ventricular cells of the guinea-pig. Pflugers Archiv : European journal of physiology. 410 [PubMed]

McAllister RE, Noble D, Tsien RW. (1975). Reconstruction of the electrical activity of cardiac Purkinje fibres. The Journal of physiology. 251 [PubMed]

McDonald TF, Trautwein W. (1978). The potassium current underlying delayed rectification in cat ventricular muscle. The Journal of physiology. 274 [PubMed]

Moore JW, Ramon F. (1974). On numerical integration of the Hodgkin and Huxley equations for a membrane action potential. Journal of theoretical biology. 45 [PubMed]

Nilius B. (1988). Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106. The Journal of physiology. 399 [PubMed]

Patlak JB, Ortiz M. (1985). Slow currents through single sodium channels of the adult rat heart. The Journal of general physiology. 86 [PubMed]

Quan W, Rudy Y. (1990). Unidirectional block and reentry of cardiac excitation: a model study. Circulation research. 66 [PubMed]

Robinson RB, Boyden PA, Hoffman BF, Hewett KW. (1987). Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. The American journal of physiology. 253 [PubMed]

Rudy Y, Quan W. (1989). The effects of the discrete cellular structureon propagation of excitation in cardiac tissue: A model study Cell Interactions and Gap Junctions.

Rudy Y, Quan WL. (1987). A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circulation research. 61 [PubMed]

Rush S, Larsen H. (1978). A practical algorithm for solving dynamic membrane equations. IEEE transactions on bio-medical engineering. 25 [PubMed]

Sakmann B, Trube G. (1984). Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. The Journal of physiology. 347 [PubMed]

Sakmann B, Trube G. (1984). Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane. The Journal of physiology. 347 [PubMed]

Scanley BE, Hanck DA, Chay T, Fozzard HA. (1990). Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. The Journal of general physiology. 95 [PubMed]

Shah AK, Cohen IS, Datyner NB. (1987). Background K+ current in isolated canine cardiac Purkinje myocytes. Biophysical journal. 52 [PubMed]

Shibasaki T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. The Journal of physiology. 387 [PubMed]

Spear JF, Moore EN. (1974). The effect of changes in rate and rhythm on supernormal excitability in the isolated Purkinje system of the dog. A possible role in re-entrant arrhythmias. Circulation. 50 [PubMed]

Tseng GN, Robinson RB, Hoffman BF. (1987). Passive properties and membrane currents of canine ventricular myocytes. The Journal of general physiology. 90 [PubMed]

Victorri B, Vinet A, Roberge FA, Drouhard JP. (1985). Numerical integration in the reconstruction of cardiac action potentials using Hodgkin-Huxley-type models. Computers and biomedical research, an international journal. 18 [PubMed]

WEIDMANN S. (1955). Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres. The Journal of physiology. 129 [PubMed]

Weidmann S. (1970). Electrical constants of trabecular muscle from mammalian heart. The Journal of physiology. 210 [PubMed]

Wenckebach KF. (1899). Zur Analyse des unregel massingen Pulses: II. Uber den regelmassig intermittirenden Puls Z F Klin Med. 37

Yue DT, Lawrence JH, Marban E. (1989). Two molecular transitions influence cardiac sodium channel gating. Science (New York, N.Y.). 244 [PubMed]

Yue DT, Marban E. (1988). A novel cardiac potassium channel that is active and conductive at depolarized potentials. Pflugers Archiv : European journal of physiology. 413 [PubMed]

Zilberter YI, Timin EN, Bendukidze ZA, Burnashev NA. (1982). Patch-voltage-clamp method for measuring fast inward current in single rat heart muscle cells. Pflugers Archiv : European journal of physiology. 394 [PubMed]

Bartocci E, Corradini F, Entcheva E, Smolka SA, Grosu R. (2008). CellExcite: an efficient simulation environment for excitable cells BMC Bioinformatics. 9(Suppl 2)

• CellExcite: an efficient simulation environment for excitable cells (Bartocci et al. 2008) [Model]

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

• Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004) [Model]

Diekman CO, Wei N. (2021). Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophysical journal. 120 [PubMed]

• Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021) [Model]

Fox JJ, McHarg JL, Gilmour RF. (2002). Ionic mechanism of electrical alternans. American journal of physiology. Heart and circulatory physiology. 282 [PubMed]

• Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007) [Model]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]

Puglisi JL, Bers DM. (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American journal of physiology. Cell physiology. 281 [PubMed]

• A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Wu SN. (2004). Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets. The Chinese journal of physiology. 47 [PubMed]

• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zhu ZI, Clancy CE. (2007). L-type Ca2+ channel mutations and T-wave alternans: a model study. American journal of physiology. Heart and circulatory physiology. 293 [PubMed]

• Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007) [Model]

Aronson RS. (1981). Afterpotentials and triggered activity in hypertrophied myocardium from rats with renal hypertension. Circulation research. 48 [PubMed]

Aronson RS, Nordin C. (1987). Interaction of oscillatory currents andsteady-state membrane conductance in isolated cardiac myocytes:experimental description and preliminary modeling of syncytialeffects Activation, Metabolism and Perfusion of the Heart.

Beeler GW, Reuter H. (1977). Reconstruction of the action potential of ventricular myocardial fibres. The Journal of physiology. 268 [PubMed]

• Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Berlin JR, Cannell MB, Lederer WJ. (1989). Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium. Circulation research. 65 [PubMed]

CRANEFIELD PF. (1965). THE FORCE OF CONTRACTION OF EXTRASYSTOLES AND THE POTENTIATION OF FORCE OF THE POSTEXTRASYSTOLIC CONTRACTION: A HISTORICAL REVIEW. Bulletin of the New York Academy of Medicine. 41 [PubMed]

Cannell MB, Lederer WJ. (1986). The arrhythmogenic current ITI in the absence of electrogenic sodium-calcium exchange in sheep cardiac Purkinje fibres. The Journal of physiology. 374 [PubMed]

Capogrossi MC, Houser SR, Bahinski A, Lakatta EG. (1987). Synchronous occurrence of spontaneous localized calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential. Circulation research. 61 [PubMed]

Capogrossi MC, Stern MD, Spurgeon HA, Lakatta EG. (1988). Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium. The Journal of general physiology. 91 [PubMed]

Coraboeuf E, Deroubaix E, Coulombe A. (1980). Acidosis-induced abnormal repolarization and repetitive activity in isolated dog Purkinje fibers. Journal de physiologie. 76 [PubMed]

Cranefield PF, Aronson RS. (1988). Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms.

Damiano BP, Rosen MR. (1984). Effects of pacing on triggered activity induced by early afterdepolarizations. Circulation. 69 [PubMed]

Doerr T, Denger R, Doerr A, Trautwein W. (1990). Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Ehara T, Noma A, Ono K. (1988). Calcium-activated non-selective cation channel in ventricular cells isolated from adult guinea-pig hearts. The Journal of physiology. 403 [PubMed]

Fabiato A. (1985). Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. The Journal of general physiology. 85 [PubMed]

Fedida D, Noble D, Rankin AC, Spindler AJ. (1987). The arrhythmogenic transient inward current iTI and related contraction in isolated guinea-pig ventricular myocytes. The Journal of physiology. 392 [PubMed]

Giles W, Shimoni Y. (1989). Comparison of sodium-calcium exchanger and transient inward currents in single cells from rabbit ventricle. The Journal of physiology. 417 [PubMed]

Hoffman BF, Rosen MR. (1981). Cellular mechanisms for cardiac arrhythmias. Circulation research. 49 [PubMed]

Isenberg G, Klöckner U. (1982). Calcium currents of isolated bovine ventricular myocytes are fast and of large amplitude. Pflugers Archiv : European journal of physiology. 395 [PubMed]

January CT, Riddle JM. (1989). Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circulation research. 64 [PubMed]

Kass RS, Tsien RW, Weingart R. (1978). Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. The Journal of physiology. 281 [PubMed]

Lipp P, Pott L. (1988). Transient inward current in guinea-pig atrial myocytes reflects a change of sodium-calcium exchange current. The Journal of physiology. 397 [PubMed]

Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Marban E, Robinson SW, Wier WG. (1986). Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. The Journal of clinical investigation. 78 [PubMed]

Matsuda H, Noma A, Kurachi Y, Irisawa H. (1982). Transient depolarization and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations. Circulation research. 51 [PubMed]

Mulder BJ, de Tombe PP, ter Keurs HE. (1989). Spontaneous and propagated contractions in rat cardiac trabeculae. The Journal of general physiology. 93 [PubMed]

Priori SG, Corr PB. (1990). Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. The American journal of physiology. 258 [PubMed]

Rosen MR. (1990). The concept of afterdepolarization Cardiac Electrophysiology: A Textbook.

Stern MD, Capogrossi MC, Lakatta EG. (1988). Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell calcium. 9 [PubMed]

Vassalle M. (1990). Overdrive suppression and overdrive excitation Cardiac Electrophysiology: A Textbook.

Wier WG, Yue DT. (1986). Intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. The Journal of physiology. 376 [PubMed]

Yue DT, Burkhoff D, Franz MR, Hunter WC, Sagawa K. (1985). Postextrasystolic potentiation of the isolated canine left ventricle. Relationship to mechanical restitution. Circulation research. 56 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research. 35 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Allen DG, Morris PG, Orchard CH, Pirolo JS. (1985). A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis. The Journal of physiology. 361 [PubMed]

Arita M, Kiyosue T. (1983). Modification of "depressed fast channel dependent slow conduction" by lidocaine and verapamil in the presence or absence of catecholamines--evidence for alteration of preferential ionic channels for slow conduction. Japanese circulation journal. 47 [PubMed]

Beeler GW, Reuter H. (1977). Reconstruction of the action potential of ventricular myocardial fibres. The Journal of physiology. 268 [PubMed]

• Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Cardinal R et al. (1981). The effects of lidocaine on intracellular and extracellular potentials, activation, and ventricular arrhythmias during acute regional ischemia in the isolated porcine heart. Circulation research. 49 [PubMed]

Cascio WE, Johnson TA, Gettes LS. (1995). Electrophysiologic changes in ischemic ventricular myocardium: I. Influence of ionic, metabolic, and energetic changes. Journal of cardiovascular electrophysiology. 6 [PubMed]

Cascio WE, Yan GX, Kléber AG. (1992). Early changes in extracellular potassium in ischemic rabbit myocardium. The role of extracellular carbon dioxide accumulation and diffusion. Circulation research. 70 [PubMed]

Cranefield PF. (1975). The conduction of the cardiac impulse.

Cranefield PF, Wit AL, Hoffman BF. (1972). Conduction of the cardiac impulse. 3. Characteristics of very slow conduction. The Journal of general physiology. 59 [PubMed]

Doering AE, Lederer WJ. (1993). The mechanism by which cytoplasmic protons inhibit the sodium-calcium exchanger in guinea-pig heart cells. The Journal of physiology. 466 [PubMed]

Downar E, Janse MJ, Durrer D. (1977). The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart. Circulation. 56 [PubMed]

Elliott AC, Smith GL, Allen DG. (1989). Simultaneous measurements of action potential duration and intracellular ATP in isolated ferret hearts exposed to cyanide. Circulation research. 64 [PubMed]

Faivre JF, Findlay I. (1990). Action potential duration and activation of ATP-sensitive potassium current in isolated guinea-pig ventricular myocytes. Biochimica et biophysica acta. 1029 [PubMed]

Friedrich M, Benndorf K, Schwalb M, Hirche H. (1990). Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Gettes LS, Cascio WE. (1992). Effect of acute ischemia on cardiac electrophysiology The heart and cardiovascular system.

Gettes LS et al. (1985). Studies concerned with slow conduction Cardiac electrophysiology and arrhythmias.

Gilmour RF, Zipes DP. (1982). Electrophysiological response of vascularized hamster cardiac transplants to ischemia. Circulation research. 50 [PubMed]

Grant AO, Strauss LJ, Wallace AG, Strauss HC. (1980). The influence of pH on th electrophysiological effects of lidocaine in guinea pig ventricular myocardium. Circulation research. 47 [PubMed]

Grant AO, Whalley DW, Wendt DJ. (1994). Electrophysiological effects of acute ischemia and reperfusion and their role in the genesis of cardiac arrhythmias Cardiac arrhythmias: mechanisms, diagnosis, and management..

Han J, So I, Kim EY, Earm YE. (1993). ATP-sensitive potassium channels are modulated by intracellular lactate in rabbit ventricular myocytes. Pflugers Archiv : European journal of physiology. 425 [PubMed]

Harvey RD, Ten Eick RE. (1989). On the role of sodium ions in the regulation of the inward-rectifying potassium conductance in cat ventricular myocytes. The Journal of general physiology. 94 [PubMed]

Irisawa H, Sato R. (1986). Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells. Circulation research. 59 [PubMed]

Janse MJ, Wit AL. (1992). The ventricular arrhythmias of ischemia and infarction: electrophysiological mechanisms.

Kagiyama Y, Hill JL, Gettes LS. (1982). Interaction of acidosis and increased extracellular potassium on action potential characteristics and conduction in guinea pig ventricular muscle. Circulation research. 51 [PubMed]

Kakei M, Noma A, Shibasaki T. (1985). Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. The Journal of physiology. 363 [PubMed]

Kaplinsky E, Ogawa S, Balke CW, Dreifus LS. (1979). Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model. Circulation. 60 [PubMed]

Kléber AG. (1983). Resting membrane potential, extracellular potassium activity, and intracellular sodium activity during acute global ischemia in isolated perfused guinea pig hearts. Circulation research. 52 [PubMed]

Kléber AG, Janse MJ, Wilms-Schopmann FJ, Wilde AA, Coronel R. (1986). Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. Circulation. 73 [PubMed]

Kléber AG, Janse MJ, van Capelle FJ, Durrer D. (1978). Mechanism and time course of S-T and T-Q segment changes during acute regional myocardial ischemia in the pig heart determined by extracellular and intracellular recordings. Circulation research. 42 [PubMed]

Kodama I, Wilde A, Janse MJ, Durrer D, Yamada K. (1984). Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle. Journal of molecular and cellular cardiology. 16 [PubMed]

Le Guennec JV, Noble D. (1994). Effects of rapid changes of external Na+ concentration at different moments during the action potential in guinea-pig myocytes. The Journal of physiology. 478 Pt 3 [PubMed]

Lederer WJ, Nichols CG, Smith GL. (1989). The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. The Journal of physiology. 413 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Maruyama T, Cascio WE, Knisley SB, Buchanan J, Gettes LS. (1991). Effects of ryanodine and BAY K 8644 on membrane properties and conduction during simulated ischemia. The American journal of physiology. 261 [PubMed]

Nichols CG, Lederer WJ. (1990). The regulation of ATP-sensitive K+ channel activity in intact and permeabilized rat ventricular myocytes. The Journal of physiology. 423 [PubMed]

Nichols CG, Lederer WJ. (1991). Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. The American journal of physiology. 261 [PubMed]

Nichols CG, Ripoll C, Lederer WJ. (1991). ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circulation research. 68 [PubMed]

Noma A. (1983). ATP-regulated K+ channels in cardiac muscle. Nature. 305 [PubMed]

Noma A, Shibasaki T. (1985). Membrane current through adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. The Journal of physiology. 363 [PubMed]

Ohya Y, Sperelakis N. (1989). ATP regulation of the slow calcium channels in vascular smooth muscle cells of guinea pig mesenteric artery. Circulation research. 64 [PubMed]

Philipson KD, Bersohn MM, Nishimoto AY. (1982). Effects of pH on Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles. Circulation research. 50 [PubMed]

Pogwizd SM, Corr PB. (1987). Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: results using three-dimensional mapping. Circulation research. 61 [PubMed]

Rush S, Larsen H. (1978). A practical algorithm for solving dynamic membrane equations. IEEE transactions on bio-medical engineering. 25 [PubMed]

Sato R, Noma A, Kurachi Y, Irisawa H. (1985). Effects of intracellular acidification on membrane currents in ventricular cells of the guinea pig. Circulation research. 57 [PubMed]

Sato T, Kiyosue T, Arita M. (1992). Inhibitory effects of palmitoylcarnitine and lysophosphatidylcholine on the sodium current of cardiac ventricular cells. Pflugers Archiv : European journal of physiology. 420 [PubMed]

Sawanobori T, Hiraoka M, Sano T. (1978). Effects of anoxia and metabolic inhibitors on reactivation of the fast sodium system Recent advances in studies on cardiac structure and metabolism. 117

Schutz E. (1936). Elektrophysiologie des Herzens bei einphasischer Ableitung Ergebn Physiol. 38

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circulation research. 80 [PubMed]

Shaw RM, Rudy YR. (1994). Electrophysiological changes of ventricular tissue under ischemic conditions: a simulation study Comp Cardiol. 16

Skinner RB, Kunze DL. (1976). Changes in extracellular potassium activity in response to decreased pH in rabbit atrial muscle. Circulation research. 39 [PubMed]

Steenbergen C, Murphy E, Watts JA, London RE. (1990). Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circulation research. 66 [PubMed]

Tani M, Neely JR. (1989). Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Circulation research. 65 [PubMed]

Venkatesh N, Lamp ST, Weiss JN. (1991). Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle. Circulation research. 69 [PubMed]

Weiss JN, Venkatesh N, Lamp ST. (1992). ATP-sensitive K+ channels and cellular K+ loss in hypoxic and ischaemic mammalian ventricle. The Journal of physiology. 447 [PubMed]

Wilde AA et al. (1990). Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel. Circulation research. 67 [PubMed]

Wu J, Corr PB. (1992). Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. The American journal of physiology. 263 [PubMed]

Yan GX, Kléber AG. (1992). Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle. Circulation research. 71 [PubMed]

Yan GX, Yamada KA, Kléber AG, McHowat J, Corr PB. (1993). Dissociation between cellular K+ loss, reduction in repolarization time, and tissue ATP levels during myocardial hypoxia and ischemia. Circulation research. 72 [PubMed]

Yatani A, Brown AM, Akaike N. (1984). Effect of extracellular pH on sodium current in isolated, single rat ventricular cells. The Journal of membrane biology. 78 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Michailova A, Saucerman J, Belik ME, McCulloch AD. (2005). Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Biophysical journal. 88 [PubMed]

Ackerman MJ. (1998). The long QT syndrome: ion channel diseases of the heart. Mayo Clinic proceedings. 73 [PubMed]

An RH et al. (1998). Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits. Circulation research. 83 [PubMed]

Antzelevitch C, Sicouri S. (1994). Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes. Journal of the American College of Cardiology. 23 [PubMed]

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Bers DM. (1993). Control of cardiac contraction by SR Ca release and sarcolemmal Ca fluxes Excitation contraction coupling and cardiac contractile force.

Brugada P, Wellens HJ. (1985). Early afterdepolarizations: role in conduction block, "prolonged repolarization-dependent reexcitation," and tachyarrhythmias in the human heart. Pacing and clinical electrophysiology : PACE. 8 [PubMed]

Burashnikov A, Antzelevitch C. (1998). Acceleration-induced action potential prolongation and early afterdepolarizations. Journal of cardiovascular electrophysiology. 9 [PubMed]

Caref EB, Restivo M, Choi BR, Salama G. (1997). Bradycardia dependent non-uniform repolarization gradients in a guinea-pig model of long QT syndrome Circulation. 96

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Compton SJ et al. (1996). Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. Circulation. 94 [PubMed]

Cranefield FP, Aronson RS. (1988). The long QT syndrome and Torsade de Pointes Cardiac arrhythmias: the role of triggered activity and other mechanisms Futura.

Deal KK, England SK, Tamkun MM. (1996). Molecular physiology of cardiac potassium channels. Physiological reviews. 76 [PubMed]

Dessertenne F. (1966). [Ventricular tachycardia with 2 variable opposing foci]. Archives des maladies du coeur et des vaisseaux. 59 [PubMed]

Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. (1995). Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. Journal of the American College of Cardiology. 26 [PubMed]

Eldar M et al. (1992). Combined use of beta-adrenergic blocking agents and long-term cardiac pacing for patients with the long QT syndrome. Journal of the American College of Cardiology. 20 [PubMed]

Habbab MA, el-Sherif N. (1990). Drug-induced torsades de pointes: role of early afterdepolarizations and dispersion of repolarization. The American journal of medicine. 89 [PubMed]

Jackman WM et al. (1988). The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Progress in cardiovascular diseases. 31 [PubMed]

January CT, Riddle JM. (1989). Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circulation research. 64 [PubMed]

Jurkiewicz NK, Sanguinetti MC. (1993). Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circulation research. 72 [PubMed]

Kay GN, Plumb VJ, Arciniegas JG, Henthorn RW, Waldo AL. (1983). Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients. Journal of the American College of Cardiology. 2 [PubMed]

Laurita KR, Girouard SD, Rosenbaum DS. (1996). Modulation of ventricular repolarization by a premature stimulus. Role of epicardial dispersion of repolarization kinetics demonstrated by optical mapping of the intact guinea pig heart. Circulation research. 79 [PubMed]

Leclercq JF, Maisonblanche P, Cauchemez B, Coumel P. (1988). Respective role of sympathetic tone and of cardiac pauses in the genesis of 62 cases of ventricular fibrillation recorded during Holter monitoring. European heart journal. 9 [PubMed]

Liu DW, Antzelevitch C. (1995). Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circulation research. 76 [PubMed]

Locati EH, Maison-Blanche P, Dejode P, Cauchemez B, Coumel P. (1995). Spontaneous sequences of onset of torsade de pointes in patients with acquired prolonged repolarization: quantitative analysis of Holter recordings. Journal of the American College of Cardiology. 25 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Marban E, Robinson SW, Wier WG. (1986). Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. The Journal of clinical investigation. 78 [PubMed]

Nitta J, Furukawa T, Marumo F, Sawanobori T, Hiraoka M. (1994). Subcellular mechanism for Ca(2+)-dependent enhancement of delayed rectifier K+ current in isolated membrane patches of guinea pig ventricular myocytes. Circulation research. 74 [PubMed]

Qin D et al. (1996). Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium. Circulation research. 79 [PubMed]

Roden DM. (1993). Early after-depolarizations and torsade de pointes: implications for the control of cardiac arrhythmias by prolonging repolarization. European heart journal. 14 Suppl H [PubMed]

Roden DM, Thompson KA, Hoffman BF, Woosley RL. (1986). Clinical features and basic mechanisms of quinidine-induced arrhythmias. Journal of the American College of Cardiology. 8 [PubMed]

Romey G et al. (1997). Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. The Journal of biological chemistry. 272 [PubMed]

Rudy Y, Viswanathan PC. (1997). Differential sensitivity of ventricular cell types to class III antiarrhythmic agents Biophys J. 72

Shimizu W, Antzelevitch C. (1997). Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation. 96 [PubMed]

Shimizu W et al. (1998). Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome. Circulation. 97 [PubMed]

Shimizu W et al. (1995). Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. Journal of the American College of Cardiology. 26 [PubMed]

Sicouri S, Antzelevitch C. (1991). A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circulation research. 68 [PubMed]

Sicouri S, Quist M, Antzelevitch C. (1996). Evidence for the presence of M cells in the guinea pig ventricle. Journal of cardiovascular electrophysiology. 7 [PubMed]

Surawicz B. (1989). Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations? Journal of the American College of Cardiology. 14 [PubMed]

Verduyn SC, Vos MA, van der Zande J, van der Hulst FF, Wellens HJ. (1997). Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium. Cardiovascular research. 34 [PubMed]

Vincent GM. (1998). The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. Annual review of medicine. 49 [PubMed]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Vos MA, Verduyn SC, Gorgels AP, Lipcsei GC, Wellens HJ. (1995). Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation. 91 [PubMed]

Wang DW, Yazawa K, Makita N, George AL, Bennett PB. (1997). Pharmacological targeting of long QT mutant sodium channels. The Journal of clinical investigation. 99 [PubMed]

Wang Q, Chen Q, Towbin JA. (1998). Genetics, molecular mechanisms and management of long QT syndrome. Annals of medicine. 30 [PubMed]

Zabel M et al. (1997). Electrophysiologic features of torsades de pointes: insights from a new isolated rabbit heart model. Journal of cardiovascular electrophysiology. 8 [PubMed]

Zeng J. (1997). A dynamic model of a cardiac ventricular action potential Thesis.

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zhou JT, Zheng LR, Liu WY. (1992). Role of early afterdepolarization in familial long QTU syndrome and torsade de pointes. Pacing and clinical electrophysiology : PACE. 15 [PubMed]

el-Sherif N, Caref EB, Yin H, Restivo M. (1996). The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circulation research. 79 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Balser JR, Roden DM, Bennett PB. (1990). Global parameter optimization for cardiac potassium channel gating models. Biophysical journal. 57 [PubMed]

Barinaga M. (1998). Tracking down mutations that can stop the heart. Science (New York, N.Y.). 281 [PubMed]

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Dumaine R et al. (1996). Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation research. 78 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

• Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
• Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
• Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]
• Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]

Hanck DA. (1995). Cardiac Electrophysiology: From Cell To Bedside.

Keating MT, Sanguinetti MC. (1996). Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272 [PubMed]

Kunkel TA, Wilson SH. (1996). DNA repair. Push and pull of base flipping. Nature. 384 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Mitsuiye T, Noma A. (1995). Inactivation of the cardiac Na+ channels in guinea-pig ventricular cells through the open state. The Journal of physiology. 485 ( Pt 3) [PubMed]

Schwartz PJ et al. (1995). Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 92 [PubMed]

Tomaselli GF et al. (1995). A mutation in the pore of the sodium channel alters gating. Biophysical journal. 68 [PubMed]

Wang DW, Yazawa K, George AL, Bennett PB. (1996). Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]

Wang DW, Yazawa K, Makita N, George AL, Bennett PB. (1997). Pharmacological targeting of long QT mutant sodium channels. The Journal of clinical investigation. 99 [PubMed]

Welsh MJ, Hoshi T. (1995). Molecular cardiology. Ion channels lose the rhythm. Nature. 376 [PubMed]

Yang XL, Wu SM. (1989). Modulation of rod-cone coupling by light. Science (New York, N.Y.). 244 [PubMed]

Zeng J. (1997). Biomedical Engineering.

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

• Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004) [Model]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

• Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Dahlem MA, Schumacher J, Hübel N. (2014). Linking a genetic defect in migraine to spreading depression in a computational model. PeerJ. 2 [PubMed]

• Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014) [Model]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Kahlig KM, Misra SN, George AL. (2006). Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]

Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation research. 89 [PubMed]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Winslow RL, Greenstein JL. (2004). The ongoing journey to understand heart function through integrative modeling. Circulation research. 95 [PubMed]

Xu J, Clancy CE. (2008). Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PloS one. 3 [PubMed]

• Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008) [Model]

Antzelevitch C, Sicouri S. (1993). Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis. J Cardiovasc Electrophysiol. 4

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. (1995). Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. Journal of the American College of Cardiology. 26 [PubMed]

Huang XD, Sandusky GE, Zipes DP. (1999). Heterogeneous loss of connexin43 protein in ischemic dog hearts. Journal of cardiovascular electrophysiology. 10 [PubMed]

Liu DW, Antzelevitch C. (1995). Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circulation research. 76 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Peters NS, Coromilas J, Severs NJ, Wit AL. (1997). Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation. 95 [PubMed]

Pogwizd SM, McKenzie JP, Cain ME. (1998). Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation. 98 [PubMed]

Priori SG et al. (1999). Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II. Circulation. 99 [PubMed]

Shaw RM, Rudy Y. (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circulation research. 81 [PubMed]

Shimizu W, Antzelevitch C. (1998). Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation. 98 [PubMed]

Sicouri S, Antzelevitch C. (1991). A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circulation research. 68 [PubMed]

Tieleman RG et al. (1998). Early recurrences of atrial fibrillation after electrical cardioversion: a result of fibrillation-induced electrical remodeling of the atria? Journal of the American College of Cardiology. 31 [PubMed]

Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Yan GX, Shimizu W, Antzelevitch C. (1998). Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation. 98 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zipes DP, Wellens HJ. (1998). Sudden cardiac death. Circulation. 98 [PubMed]

el-Sherif N, Caref EB, Yin H, Restivo M. (1996). The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circulation research. 79 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Berlin JR, Cannell MB, Lederer WJ. (1987). Regulation of twitch tension in sheep cardiac Purkinje fibers during calcium overload. The American journal of physiology. 253 [PubMed]

Bers DM, Christensen DM, Nguyen TX. (1988). Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction? Journal of molecular and cellular cardiology. 20 [PubMed]

Brill DM, Wasserstrom JA. (1986). Intracellular sodium and the positive inotropic effect of veratridine and cardiac glycoside in sheep Purkinje fibers. Circulation research. 58 [PubMed]

Carl SL et al. (1995). Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. The Journal of cell biology. 129 [PubMed]

Carmeliet E. (1992). A fuzzy subsarcolemmal space for intracellular Na+ in cardiac cells? Cardiovascular research. 26 [PubMed]

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Cohen CJ, Fozzard HA, Sheu SS. (1982). Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circulation research. 50 [PubMed]

Cranefield PF, Aronson RS. (1988). Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms.

Dumaine R et al. (1996). Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation research. 78 [PubMed]

Ellis D. (1977). The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres. The Journal of physiology. 273 [PubMed]

Ferrier GR, Howlett SE. (1995). Contractions in guinea-pig ventricular myocytes triggered by a calcium-release mechanism separate from Na+ and L-currents. The Journal of physiology. 484 ( Pt 1) [PubMed]

Frank JS, Mottino G, Reid D, Molday RS, Philipson KD. (1992). Distribution of the Na(+)-Ca2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study. The Journal of cell biology. 117 [PubMed]

Gao T et al. (1997). Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. The Journal of biological chemistry. 272 [PubMed]

Haigney MC, Lakatta EG, Stern MD, Silverman HS. (1994). Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation. 90 [PubMed]

Harrison SM, McCall E, Boyett MR. (1992). The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes. The Journal of physiology. 449 [PubMed]

Hess P, Wier WG. (1984). Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol. 83

Irisawa H, Sato R. (1986). Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells. Circulation research. 59 [PubMed]

Kameyama M et al. (1984). Intracellular Na+ activates a K+ channel in mammalian cardiac cells. Nature. 309 [PubMed]

Karmazyn M. (1996). The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications. The Canadian journal of cardiology. 12 [PubMed]

Kieval RS, Bloch RJ, Lindenmayer GE, Ambesi A, Lederer WJ. (1992). Immunofluorescence localization of the Na-Ca exchanger in heart cells. The American journal of physiology. 263 [PubMed]

Kohomoto O, Levi AJ, Bridge JH. (1994). Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circulation research. 74 [PubMed]

Leblanc N, Hume JR. (1990). Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science (New York, N.Y.). 248 [PubMed]

Levesque PC, Leblanc N, Hume JR. (1994). Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange. Cardiovascular research. 28 [PubMed]

Levi AJ. (1991). The effect of strophanthidin on action potential, calcium current and contraction in isolated guinea-pig ventricular myocytes. The Journal of physiology. 443 [PubMed]

Levi AJ. (1993). A role for sodium/calcium exchange in the action potential shortening caused by strophanthidin in guinea pig ventricular myocytes. Cardiovascular research. 27 [PubMed]

Levi AJ et al. (1997). Role of intracellular sodium overload in the genesis of cardiac arrhythmias. Journal of cardiovascular electrophysiology. 8 [PubMed]

Levi AJ, Spitzer KW, Kohmoto O, Bridge JH. (1994). Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. The American journal of physiology. 266 [PubMed]

Litwin S, Kohmoto O, Levi AJ, Spitzer KW, Bridge JH. (1996). Evidence that reverse Na-Ca exchange can trigger SR calcium release. Annals of the New York Academy of Sciences. 779 [PubMed]

Litwin SE, Bridge JH. (1997). Enhanced Na(+)-Ca2+ exchange in the infarcted heart. Implications for excitation-contraction coupling. Circulation research. 81 [PubMed]

Litwin SE, Li J, Bridge JH. (1998). Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophysical journal. 75 [PubMed]

Lu HR, De Clerck F. (1993). R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. Journal of cardiovascular pharmacology. 22 [PubMed]

Luk HN, Carmeliet E. (1990). Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
• Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]

Matsuoka S, Hilgemann DW. (1992). Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle. The Journal of general physiology. 100 [PubMed]

Nagatomo T et al. (1998). Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels. The American journal of physiology. 275 [PubMed]

Nakao M, Gadsby DC. (1989). [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. The Journal of general physiology. 94 [PubMed]

Nuss HB, Houser SR. (1992). Sodium-calcium exchange-mediated contractions in feline ventricular myocytes. The American journal of physiology. 263 [PubMed]

Radford NB, Makos JD, Ramasamy R, Sherry AD, Malloy CR. (1998). Dissociation of intracellular sodium from contractile state in guinea-pig hearts treated with ouabain. Journal of molecular and cellular cardiology. 30 [PubMed]

Ravens U, Himmel HM. (1999). Drugs preventing Na+ and Ca2+ overload. Pharmacological research. 39 [PubMed]

Sanguinetti MC. (1990). Na+-activated and ATP-sensitive K+ channels in the heart Potassium Channels: Basic Function and Therapeutic Aspects.

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research. 35 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Sipido KR, Maes M, Van de Werf F. (1997). Low efficiency of Ca2+ entry through the Na(+)-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum. A comparison between L-type Ca2+ current and reverse-mode Na(+)-Ca2+ exchange. Circulation research. 81 [PubMed]

Smith TW, Antman EM, Friedman PL, Blatt CM, Marsh JD. (1984). Digitalis glycosides: mechanisms and manifestations of toxicity. Part I. Progress in cardiovascular diseases. 26 [PubMed]

Tani M, Neely JR. (1990). Na+ accumulation increases Ca2+ overload and impairs function in anoxic rat heart. Journal of molecular and cellular cardiology. 22 [PubMed]

Varghese A, Sell GR. (1997). A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells. Journal of theoretical biology. 189 [PubMed]

Veldkamp MW, Vereecke J, Carmeliet E. (1994). Effects of intracellular sodium and hydrogen ion on the sodium activated potassium channel in isolated patches from guinea pig ventricular myocytes. Cardiovascular research. 28 [PubMed]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Vornanen M, Shepherd N, Isenberg G. (1994). Tension-voltage relations of single myocytes reflect Ca release triggered by Na/Ca exchange at 35 degrees C but not 23 degrees C. The American journal of physiology. 267 [PubMed]

Wang DY, Chae SW, Gong QY, Lee CO. (1988). Role of aiNa in positive force-frequency staircase in guinea pig papillary muscle. The American journal of physiology. 255 [PubMed]

Wang Z, Kimitsuki T, Noma A. (1991). Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells. The Journal of physiology. 433 [PubMed]

Wasserstrom JA, Vites AM. (1999). Activation of contraction in cat ventricular myocytes: effects of low Cd(2+) concentration and temperature. The American journal of physiology. 277 [PubMed]

Wendt-Gallitelli MF, Voigt T, Isenberg G. (1993). Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea-pig ventricular myocytes. The Journal of physiology. 472 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

van Echteld CJ, Kirkels JH, Eijgelshoven MH, van der Meer P, Ruigrok TJ. (1991). Intracellular sodium during ischemia and calcium-free perfusion: a 23Na NMR study. Journal of molecular and cellular cardiology. 23 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006) [Model]

Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]

• Excitation-contraction coupling in an integrative heart cell model (Greenstein et al 2006) [Model]

Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]

• HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011) [Model]

Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004). A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophysical journal. 87 [PubMed]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Severi S, Corsi C, Rocchetti M, Zaza A. (2009). Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophysical journal. 96 [PubMed]

• A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009) [Model]

Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

• Simulation study of Andersen-Tawil syndrome (Sung et al 2006) [Model]

Amberg GC, Bonev AD, Rossow CF, Nelson MT, Santana LF. (2003). Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. The Journal of clinical investigation. 112 [PubMed]

Butler A, Tsunoda S, McCobb DP, Wei A, Salkoff L. (1993). mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science (New York, N.Y.). 261 [PubMed]

Camelliti P, Borg TK, Kohl P. (2005). Structural and functional characterisation of cardiac fibroblasts. Cardiovascular research. 65 [PubMed]

Camelliti P, Green CR, LeGrice I, Kohl P. (2004). Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circulation research. 94 [PubMed]

Chilton L et al. (2005). K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. American journal of physiology. Heart and circulatory physiology. 288 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

• Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001) [Model]

El Chemaly A et al. (2006). A voltage-activated proton current in human cardiac fibroblasts. Biochemical and biophysical research communications. 340 [PubMed]

Ermentrout GB. (2002). Simulating, Analyzing, and Animating Dynamical System: A Guide to XPPAUT for Researchers and Students Society for Industrial and Applied Mathematics (SIAM).

Gaudesius G, Miragoli M, Thomas SP, Rohr S. (2003). Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circulation research. 93 [PubMed]

Guinamard R et al. (2004). Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes. The Journal of physiology. 558 [PubMed]

Horrigan FT, Cui J, Aldrich RW. (1999). Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). The Journal of general physiology. 114 [PubMed]

• Allosteric gating of K channels (Horrigan et al 1999) [Model]

Kamkin A, Kiseleva I, Lozinsky I, Scholz H. (2005). Electrical interaction of mechanosensitive fibroblasts and myocytes in the heart. Basic research in cardiology. 100 [PubMed]

Keener JP, Keizer JE. (2002). Fast and slow time scales (Chapter 4) Computational Cell Biology.

Kizana E, Ginn SL, Allen DG, Ross DL, Alexander IE. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation. 111 [PubMed]

Knaus HG, Toro L, Meera P, Tanaka Y, Song M. (1997). Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes. J Physiol. 502 ( Pt 3)

Kohl P, Camelliti P, Burton FL, Smith GL. (2005). Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of electrocardiology. 38 [PubMed]

Kohl P, Hunter P, Noble D. (1999). Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models. Progress in biophysics and molecular biology. 71 [PubMed]

Lin MW, Yang SR, Huang MH, Wu SN. (2004). Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells. The Journal of biological chemistry. 279 [PubMed]

Lippiat JD, Standen NB, Davies NW. (2000). A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKCa) channels. The Journal of physiology. 529 Pt 1 [PubMed]

Lo YC, Yang SR, Huang MH, Liu YC, Wu SN. (2005). Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells. Life sciences. 76 [PubMed]

Lo YK, Wu SN, Lee CT, Li HF, Chiang HT. (2001). Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH3 cells. Pflugers Archiv : European journal of physiology. 442 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

• Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Moczydlowski E, Latorre R. (1983). Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. The Journal of general physiology. 82 [PubMed]

• Ca-dependent K Channel: kinetics from rat muscle (Moczydlowski, Latorre 1983) NEURON [Model]
• Ca-dependent K Channel: kinetics from rat muscle (Moczydlowski, Latorre 1983) XPP [Model]

Peng J, Gurantz D, Tran V, Cowling RT, Greenberg BH. (2002). Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis. Circulation research. 91 [PubMed]

Peracchia C. (2004). Chemical gating of gap junction channels; roles of calcium, pH and calmodulin. Biochimica et biophysica acta. 1662 [PubMed]

Rohr S. (2004). Role of gap junctions in the propagation of the cardiac action potential. Cardiovascular research. 62 [PubMed]

Rothberg BS, Magleby KL. (1999). Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. The Journal of general physiology. 114 [PubMed]

Salameh A et al. (2006). Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20 [PubMed]

Sato T, Saito T, Saegusa N, Nakaya H. (2005). Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A. Circulation. 111 [PubMed]

Silva J, Rudy Y. (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112 [PubMed]

• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) [Model]
• Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP) [Model]

Wang W, Watanabe M, Nakamura T, Kudo Y, Ochi R. (1999). Properties and expression of Ca2+-activated K+ channels in H9c2 cells derived from rat ventricle. The American journal of physiology. 276 [PubMed]

Wang YJ, Liu YC, Chang HD, Wu SN. (2006). Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells. Planta medica. 72 [PubMed]

Wilson JR, Duncan NA, Giles WR, Clark RB. (2004). A voltage-dependent K+ current contributes to membrane potential of acutely isolated canine articular chondrocytes. The Journal of physiology. 557 [PubMed]

Wu SN. (2003). Large-conductance Ca2+- activated K+ channels:physiological role and pharmacology. Current medicinal chemistry. 10 [PubMed]

Wu SN, Chiang HT, Chang FR, Liaw CC, Wu YC. (2003). Stimulatory effects of squamocin, an Annonaceous acetogenin, on Ca(2+)-activated K+ current in cultured smooth muscle cells of human coronary artery. Chemical research in toxicology. 16 [PubMed]

Wu SN, Lin PH, Hsieh KS, Liu YC, Chiang HT. (2003). Behavior of nonselective cation channels and large-conductance Ca2+-activated K+ channels induced by dynamic changes in membrane stretch in cultured smooth muscle cells of human coronary artery. Journal of cardiovascular electrophysiology. 14 [PubMed]

Wu SN, Liu SI, Hwang TL. (1998). Activation of muscarinic K+ channels by extracellular ATP and UTP in rat atrial myocytes. Journal of cardiovascular pharmacology. 31 [PubMed]

Xu Y et al. (2003). Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. The Journal of biological chemistry. 278 [PubMed]

ten Tusscher KH, Noble D, Noble PJ, Panfilov AV. (2004). A model for human ventricular tissue. American journal of physiology. Heart and circulatory physiology. 286 [PubMed]

Wang YJ et al. (2008). Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. Toxicological sciences : an official journal of the Society of Toxicology. 106 [PubMed]

• Action potential of adult rat ventricle (Wang et al. 2008) [Model]