Robust transmission in the inhibitory Purkinje Cell to Cerebellar Nuclei pathway (Abbasi et al 2017)


Jaeger D et al. (2017). Robust Transmission of Rate Coding in the Inhibitory Purkinje Cell to Cerebellar Nuclei Pathway in Awake Mice PLOS Computational Biology.

See more from authors: Jaeger D · Cao Y · Maran SK · Heck DH · Abbasi S · Abbasi A · Hudson AE

References and models cited by this paper

Aizenman CD, Linden DJ. (1999). Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. Journal of neurophysiology. 82 [PubMed]

Anchisi D, Scelfo B, Tempia F. (2001). Postsynaptic currents in deep cerebellar nuclei. Journal of neurophysiology. 85 [PubMed]

Audinat E, Gähwiler BH, Knöpfel T. (1992). Excitatory synaptic potentials in neurons of the deep nuclei in olivo-cerebellar slice cultures. Neuroscience. 49 [PubMed]

Bryant JL, Boughter JD, Gong S, LeDoux MS, Heck DH. (2010). Cerebellar cortical output encodes temporal aspects of rhythmic licking movements and is necessary for normal licking frequency. The European journal of neuroscience. 32 [PubMed]

Cao Y, Maran SK, Dhamala M, Jaeger D, Heck DH. (2012). Behavior-related pauses in simple-spike activity of mouse Purkinje cells are linked to spike rate modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Cao Y, Roy S, Sachdev RN, Heck DH. (2012). Dynamic correlation between whisking and breathing rhythms in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

De Zeeuw CI et al. (2011). Spatiotemporal firing patterns in the cerebellum. Nature reviews. Neuroscience. 12 [PubMed]

Deister CA, Chan CS, Surmeier DJ, Wilson CJ. (2009). Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Diesmann M, Gewaltig MO, Aertsen A. (1999). Stable propagation of synchronous spiking in cortical neural networks. Nature. 402 [PubMed]

Edgerton JR, Jaeger D. (2011). Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Eliasmith C et al. (2012). A large-scale model of the functioning brain. Science (New York, N.Y.). 338 [PubMed]

Feng SS, Lin R, Gauck V, Jaeger D. (2013). Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance. Cerebellum (London, England). 12 [PubMed]

Gauck V, Jaeger D. (2000). The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Gauck V, Jaeger D. (2003). The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Georgopoulos AP, Kalaska JF, Caminiti R, Massey JT. (1982). On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2 [PubMed]

Heck D, Kümmell F, Thach WT, Aertsena A. (2002). Dynamic correlation of neuronal activity in rat cerebellar cortex modulated by behavior. Annals of the New York Academy of Sciences. 978 [PubMed]

Heck DH, De Zeeuw CI, Jaeger D, Khodakhah K, Person AL. (2013). The neuronal code(s) of the cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Hoebeek FE, Witter L, Ruigrok TJ, De Zeeuw CI. (2010). Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Jaeger D. (2003). No Parallel Fiber Volleys in the Cerebellar Cortex: Evidence from Cross-Correlation Analysis between Purkinje Cells in a Computer Model and in Recordings from Anesthetized Rats Journal of computational neuroscience. 14 [PubMed]

Jahnsen H. (1986). Electrophysiological characteristics of neurones in the guinea-pig deep cerebellar nuclei in vitro. The Journal of physiology. 372 [PubMed]

Kalmbach BE, Voicu H, Ohyama T, Mauk MD. (2011). A subtraction mechanism of temporal coding in cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Keele SW, Ivry R. (1990). Does the cerebellum provide a common computation for diverse tasks? A timing hypothesis. Annals of the New York Academy of Sciences. 608 [PubMed]

Koyama S, Omi T, Kass RE, Shinomoto S. (2013). Information transmission using non-poisson regular firing. Neural computation. 25 [PubMed]

Lin RJ, Jaeger D. (2011). Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. Journal of neurophysiology. 105 [PubMed]

Lu L, Cao Y, Tokita K, Heck DH, Boughter JD. (2013). Medial cerebellar nuclear projections and activity patterns link cerebellar output to orofacial and respiratory behavior. Frontiers in neural circuits. 7 [PubMed]

Mihailoff GA. (1994). Identification of pontocerebellar axon collateral synaptic boutons in the rat cerebellar nuclei. Brain research. 648 [PubMed]

Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. (2014). Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. Journal of neurochemistry. 130 [PubMed]

Palkovits M, Mezey E, Hámori J, Szentágothai J. (1977). Quantitative histological analysis of the cerebellar nuclei in the cat. I. Numerical data on cells and on synapses. Experimental brain research. 28 [PubMed]

Paulin MG. (1995). System identification of spiking sensory neurons using realistically constrained nonlinear time series models. Advances in processing and pattern analysis of biological signals.

Paulin MG, Hoffman LF. (2001). Optimal firing rate estimation. Neural networks : the official journal of the International Neural Network Society. 14 [PubMed]

Person AL, Raman IM. (2011). Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature. 481 [PubMed]

Prsa M, Dash S, Catz N, Dicke PW, Thier P. (2009). Characteristics of responses of Golgi cells and mossy fibers to eye saccades and saccadic adaptation recorded from the posterior vermis of the cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Pugh JR, Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron. 51 [PubMed]

Raman IM, Gustafson AE, Padgett D. (2000). Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Roxin A, Brunel N, Hansel D, Mongillo G, van Vreeswijk C. (2011). On the distribution of firing rates in networks of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Rudolph M, Destexhe A. (2003). The discharge variability of neocortical neurons during high-conductance states. Neuroscience. 119 [PubMed]

Sangrey T, Jaeger D. (2010). Analysis of distinct short and prolonged components in rebound spiking of deep cerebellar nucleus neurons. The European journal of neuroscience. 32 [PubMed]

Schulz DJ, Goaillard JM, Marder E. (2006). Variable channel expression in identified single and electrically coupled neurons in different animals. Nature neuroscience. 9 [PubMed]

Shai AS, Anastassiou CA, Larkum ME, Koch C. (2015). Physiology of layer 5 pyramidal neurons in mouse primary visual cortex: coincidence detection through bursting. PLoS computational biology. 11 [PubMed]

Shinomoto S, Miura K, Koyama S. (2005). A measure of local variation of inter-spike intervals. Bio Systems. 79 [PubMed]

Shinomoto S, Shima K, Tanji J. (2003). Differences in spiking patterns among cortical neurons. Neural computation. 15 [PubMed]

Softky WR, Koch C. (1993). The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

Steuber V et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron. 54 [PubMed]

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW. (2009). Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels (Austin, Tex.). 3 [PubMed]

Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM. (2004). Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron. 41 [PubMed]

Telgkamp P, Raman IM. (2002). Depression of inhibitory synaptic transmission between Purkinje cells and neurons of the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Thach WT. (1968). Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. Journal of neurophysiology. 31 [PubMed]

VanderHorst VG, Ulfhake B. (2006). The organization of the brainstem and spinal cord of the mouse: relationships between monoaminergic, cholinergic, and spinal projection systems. Journal of chemical neuroanatomy. 31 [PubMed]

Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. (2011). Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. Science (New York, N.Y.). 334 [PubMed]

Walter JT, Khodakhah K. (2006). The linear computational algorithm of cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Walter JT, Khodakhah K. (2009). The advantages of linear information processing for cerebellar computation. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Wilbur WJ, Rinzel J. (1983). A theoretical basis for large coefficient of variation and bimodality in neuronal interspike interval distributions. Journal of theoretical biology. 105 [PubMed]

Xu F, Frazier DT. (2000). Modulation of respiratory motor output by cerebellar deep nuclei in the rat. Journal of applied physiology (Bethesda, Md. : 1985). 89 [PubMed]

van Vreeswijk C, Sompolinsky H. (1998). Chaotic balanced state in a model of cortical circuits. Neural computation. 10 [PubMed]

van der Want JJ, Gerrits NM, Voogd J. (1987). Autoradiography of mossy fiber terminals in the fastigial nucleus of the cat. The Journal of comparative neurology. 258 [PubMed]

References and models that cite this paper

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

See more from authors: Steuber V · Schultheiss NW · Silver RA · De Schutter E · Jaeger D

References and models cited by this paper

Achard P, De Schutter E. (2006). Complex parameter landscape for a complex neuron model. PLoS computational biology. 2 [PubMed]

Aizenman CD, Linden DJ. (1999). Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. Journal of neurophysiology. 82 [PubMed]

Aizenman CD, Linden DJ. (2000). Rapid, synaptically driven increases in the intrinsic excitability of cerebellar deep nuclear neurons. Nature neuroscience. 3 [PubMed]

Alviña K, Khodakhah K. (2008). Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats. The Journal of physiology. 586 [PubMed]

Alviña K, Walter JT, Kohn A, Ellis-Davies G, Khodakhah K. (2008). Questioning the role of rebound firing in the cerebellum. Nature neuroscience. 11 [PubMed]

Alzheimer C, Schwindt PC, Crill WE. (1993). Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Anchisi D, Scelfo B, Tempia F. (2001). Postsynaptic currents in deep cerebellar nuclei. Journal of neurophysiology. 85 [PubMed]

Aracri P et al. (2006). Layer-specific properties of the persistent sodium current in sensorimotor cortex. Journal of neurophysiology. 95 [PubMed]

Banke TG, McBain CJ. (2006). GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ. (2003). Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature neuroscience. 6 [PubMed]

Baranauskas G, Tkatch T, Surmeier DJ. (1999). Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Bower JM. (1997). Is the cerebellum sensory for motor's sake, or motor for sensory's sake: the view from the whiskers of a rat? Progress in brain research. 114 [PubMed]

Bower JM, Beeman D. (1995). The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System..

Brown AM, Schwindt PC, Crill WE. (1994). Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels. Journal of neurophysiology. 71 [PubMed]

Cavdar S, San T, Aker R, Sehirli U, Onat F. (2001). Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat. Journal of anatomy. 198 [PubMed]

Choi JS, Moore JW. (2003). Cerebellar neuronal activity expresses the complex topography of conditioned eyeblink responses. Behavioral neuroscience. 117 [PubMed]

Daniel H, Billard JM, Angaut P, Batini C. (1987). The interposito-rubrospinal system. Anatomical tracing of a motor control pathway in the rat. Neuroscience research. 5 [PubMed]

De Schutter E, Bower JM. (1994). An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. Journal of neurophysiology. 71 [PubMed]

De Schutter E, Jaeger D, Steuber V. (2004). Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors Neurocomputing. 58-60

Destexhe A, Neubig M, Ulrich D, Huguenard J. (1998). Dendritic low-threshold calcium currents in thalamic relay cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Fredette BJ, Mugnaini E. (1991). The GABAergic cerebello-olivary projection in the rat. Anatomy and embryology. 184 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. I. Postsynaptic potentials. Brain research. 351 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. II. Membrane conductances. Brain research. 352 [PubMed]

Gardner EP, Fuchs AF. (1975). Single-unit responses to natural vestibular stimuli and eye movements in deep cerebellar nuclei of the alert rhesus monkey. Journal of neurophysiology. 38 [PubMed]

Gauck V, Jaeger D. (2000). The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Gauck V, Jaeger D. (2003). The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Gauck V, Thomann M, Jaeger D, Borst A. (2001). Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Gibson AR, Horn KM, Stein JF, Van Kan PL. (1996). Activity of interpositus neurons during a visually guided reach. Canadian journal of physiology and pharmacology. 74 [PubMed]

Gleeson P et al. (2010). NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS computational biology. 6 [PubMed]

Goodkin HP, Thach WT. (2003). Cerebellar control of constrained and unconstrained movements. II. EMG and nuclear activity. Journal of neurophysiology. 89 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hartline DK, Castelfranco AM. (2002). Simulations of space-clamp errors in estimating parameters of voltage-gated conductances localized at different electrotonic distances Neurocomputing. 44

Hepp K, Henn V, Jaeger J. (1982). Eye movement related neurons in the cerebellar nuclei of the alert monkey. Experimental brain research. 45 [PubMed]

Hille B. (2001). Ionic Channels of Excitable Membranes.

Houk JC, Buckingham JT, Barto AG. (1996). Models of the cerebellum and motor learning. Behav Brain Sci. 19

Ito M. (2008). Control of mental activities by internal models in the cerebellum. Nature reviews. Neuroscience. 9 [PubMed]

Ivry R, Keele S. (1989). Timing function of the cerebellum J Cognit Neurosci. 1

Jaeger D. (2003). No Parallel Fiber Volleys in the Cerebellar Cortex: Evidence from Cross-Correlation Analysis between Purkinje Cells in a Computer Model and in Recordings from Anesthetized Rats Journal of computational neuroscience. 14 [PubMed]

Jaeger D, Bower JM. (1999). Synaptic control of spiking in cerebellar Purkinje cells: dynamic current clamp based on model conductances. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Jaeger D, Sangrey TD. (2005). Currents underlying hyperpolarization-induced rebound spiking in deep cerebellar nuclei neurons Society for Neuroscience Abstract 179.10.

Jagodic MM et al. (2007). Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Jahnsen H. (1986). Electrophysiological characteristics of neurones in the guinea-pig deep cerebellar nuclei in vitro. The Journal of physiology. 372 [PubMed]

Jahnsen H. (1986). Extracellular activation and membrane conductances of neurones in the guinea-pig deep cerebellar nuclei in vitro. The Journal of physiology. 372 [PubMed]

Kleine JF, Guan Y, Buttner U. (2003). Saccade-related neurons in the primate fastigial nucleus: what do they encode? Journal of neurophysiology. 90 [PubMed]

Lang EJ, Sugihara I, Welsh JP, Llinás R. (1999). Patterns of spontaneous purkinje cell complex spike activity in the awake rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Lee HH et al. (2007). Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. The Journal of biological chemistry. 282 [PubMed]

Llinás R, Mühlethaler M. (1988). Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. The Journal of physiology. 404 [PubMed]

MacKay WA. (1988). Cerebellar nuclear activity in relation to simple movements. Experimental brain research. 71 [PubMed]

Magistretti J, Alonso A. (1999). Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study. The Journal of general physiology. 114 [PubMed]

Medina JF, Garcia KS, Nores WL, Taylor NM, Mauk MD. (2000). Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Molineux ML et al. (2006). Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Muri R, Knöpfel T. (1994). Activity induced elevations of intracellular calcium concentration in neurons of the deep cerebellar nuclei. Journal of neurophysiology. 71 [PubMed]

Otsuka T, Abe T, Tsukagawa T, Song WJ. (2004). Conductance-based model of the voltage-dependent generation of a plateau potential in subthalamic neurons. Journal of neurophysiology. 92 [PubMed]

Palkovits M, Mezey E, Hámori J, Szentágothai J. (1977). Quantitative histological analysis of the cerebellar nuclei in the cat. I. Numerical data on cells and on synapses. Experimental brain research. 28 [PubMed]

Pape HC. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual review of physiology. 58 [PubMed]

Paulin MG. (1995). System identification of spiking sensory neurons using realistically constrained nonlinear time series models. Advances in processing and pattern analysis of biological signals.

Pedroarena CM. (2010). Mechanisms supporting transfer of inhibitory signals into the spike output of spontaneously firing cerebellar nuclear neurons in vitro. Cerebellum (London, England). 9 [PubMed]

Prinz AA, Billimoria CP, Marder E. (2003). Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons. Journal of neurophysiology. 90 [PubMed]

Pugh JR, Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron. 51 [PubMed]

Pugh JR, Raman IM. (2008). Mechanisms of potentiation of mossy fiber EPSCs in the cerebellar nuclei by coincident synaptic excitation and inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Purvis LK, Butera RJ. (2005). Ionic current model of a hypoglossal motoneuron. Journal of neurophysiology. 93 [PubMed]

Quaia C, Lefèvre P, Optican LM. (1999). Model of the control of saccades by superior colliculus and cerebellum. Journal of neurophysiology. 82 [PubMed]

RALL W. (1959). Branching dendritic trees and motoneuron membrane resistivity. Experimental neurology. 1 [PubMed]

Raman IM, Gustafson AE, Padgett D. (2000). Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Rivera C et al. (1999). The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature. 397 [PubMed]

Robinson DA. (1976). Adaptive gain control of vestibuloocular reflex by the cerebellum. Journal of neurophysiology. 39 [PubMed]

Rothman JS, Cathala L, Steuber V, Silver RA. (2009). Synaptic depression enables neuronal gain control. Nature. 457 [PubMed]

Rowland NC, Jaeger D. (2005). Coding of tactile response properties in the rat deep cerebellar nuclei. Journal of neurophysiology. 94 [PubMed]

Schmahmann JD. (1991). An emerging concept. The cerebellar contribution to higher function. Archives of neurology. 48 [PubMed]

Schweighofer N, Doya K, Kuroda S. (2004). Cerebellar aminergic neuromodulation: towards a functional understanding. Brain research. Brain research reviews. 44 [PubMed]

Seth AK, Edelman GM. (2007). Distinguishing causal interactions in neural populations. Neural computation. 19 [PubMed]

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML. (1999). Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. Journal of neurophysiology. 82 [PubMed]

Shin SL et al. (2007). Regular patterns in cerebellar Purkinje cell simple spike trains. PloS one. 2 [PubMed]

Stern EA, Jaeger D, Wilson CJ. (1998). Membrane potential synchrony of simultaneously recorded striatal spiny neurons in vivo. Nature. 394 [PubMed]

Steuber V et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron. 54 [PubMed]

Sultan F, Czubayko U, Thier P. (2003). Morphological classification of the rat lateral cerebellar nuclear neurons by principal component analysis. The Journal of comparative neurology. 455 [PubMed]

Surges R et al. (2006). Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. The European journal of neuroscience. 24 [PubMed]

Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW. (2009). Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels (Austin, Tex.). 3 [PubMed]

Taylor AL, Goaillard JM, Marder E. (2009). How multiple conductances determine electrophysiological properties in a multicompartment model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM. (2004). Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron. 41 [PubMed]

Timmann D, Citron R, Watts S, Hore J. (2001). Increased variability in finger position occurs throughout overarm throws made by cerebellar and unskilled subjects. Journal of neurophysiology. 86 [PubMed]

Traboulsie A, Chemin J, Kupfer E, Nargeot J, Lory P. (2006). T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Molecular pharmacology. 69 [PubMed]

Turner RW, Mehaffey WH, Molineux ML, Nejad RT. (2007). Transient and weak bursting deep cerebellar neurons exhibit differential coding properties for membrane hyperpolarizations Society for Neuroscience Abstract 409.12.

Uusisaari M, Obata K, Knöpfel T. (2007). Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Journal of neurophysiology. 97 [PubMed]

Wetmore DZ, Mukamel EA, Schnitzer MJ. (2008). Lock-and-key mechanisms of cerebellar memory recall based on rebound currents. Journal of neurophysiology. 100 [PubMed]

Zheng N, Raman IM. (2009). Ca currents activated by spontaneous firing and synaptic disinhibition in neurons of the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Zhu L, Lovinger D, Delpire E. (2005). Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride. Journal of neurophysiology. 93 [PubMed]

van Kan PL, Houk JC, Gibson AR. (1993). Output organization of intermediate cerebellum of the monkey. Journal of neurophysiology. 69 [PubMed]

References and models that cite this paper

Fardet T, Levina A. (2020). Simple Models Including Energy and Spike Constraints Reproduce Complex Activity Patterns and Metabolic Disruptions PLoS computational biology. 16 [PubMed]

Geminiani A, Casellato C, D'Angelo E, Pedrocchi A. (2019). Complex Electroresponsive Dynamics in Olivocerebellar Neurons Represented With Extended-Generalized Leaky Integrate and Fire Models. Frontiers in computational neuroscience. 13 [PubMed]

Jaeger D et al. (2017). Robust Transmission of Rate Coding in the Inhibitory Purkinje Cell to Cerebellar Nuclei Pathway in Awake Mice PLOS Computational Biology.

Lin RJ, Jaeger D. (2011). Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. Journal of neurophysiology. 105 [PubMed]

Luthman J et al. (2011). STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum (London, England). 10 [PubMed]

Ovsepian SV et al. (2013). A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. The Journal of physiology. 591 [PubMed]

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

Sudhakar SK, Torben-Nielsen B, De Schutter E. (2015). Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses. PLoS computational biology. 11 [PubMed]

Zhang X, Santaniello S. (2019). Role of cerebellar GABAergic dysfunctions in the origins of essential tremor Proceedings of the National Academy of Sciences.

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

See more from authors: Steuber V · Jaeger D

References and models cited by this paper

Abbott LF, Varela JA, Sen K, Nelson SB. (1997). Synaptic depression and cortical gain control. Science (New York, N.Y.). 275 [PubMed]

Abeles M, Hayon G, Lehmann D. (2004). Modeling compositionality by dynamic binding of synfire chains. Journal of computational neuroscience. 17 [PubMed]

Aertsen A, Diesmann M, Gewaltig MO. (1996). Propagation of synchronous spiking activity in feedforward neural networks. Journal of physiology, Paris. 90 [PubMed]

Aizenman CD, Linden DJ. (1999). Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. Journal of neurophysiology. 82 [PubMed]

Alviña K, Walter JT, Kohn A, Ellis-Davies G, Khodakhah K. (2008). Questioning the role of rebound firing in the cerebellum. Nature neuroscience. 11 [PubMed]

Anchisi D, Scelfo B, Tempia F. (2001). Postsynaptic currents in deep cerebellar nuclei. Journal of neurophysiology. 85 [PubMed]

Apps R, Garwicz M. (2000). Precise matching of olivo-cortical divergence and cortico-nuclear convergence between somatotopically corresponding areas in the medial C1 and medial C3 zones of the paravermal cerebellum. The European journal of neuroscience. 12 [PubMed]

Bengtsson F, Ekerot CF, Jörntell H. (2011). In vivo analysis of inhibitory synaptic inputs and rebounds in deep cerebellar nuclear neurons. PloS one. 6 [PubMed]

Blenkinsop TA, Lang EJ. (2011). Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Bower JM, Beeman D. (1998). The Book Of Genesis: Exploring Realistic Neural Models With The General Neural Simulation System.

Chance FS, Nelson SB, Abbott LF. (1998). Synaptic depression and the temporal response characteristics of V1 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Davie JT, Clark BA, Häusser M. (2008). The origin of the complex spike in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

De Schutter E, Jaeger D, Steuber V. (2004). Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors Neurocomputing. 58-60

De Schutter E, Steuber V. (2009). Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theory. Neuroscience. 162 [PubMed]

De Zeeuw CI et al. (2011). Spatiotemporal firing patterns in the cerebellum. Nature reviews. Neuroscience. 12 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Engbers JD et al. (2011). Distinct roles for I(T) and I(H) in controlling the frequency and timing of rebound spike responses. The Journal of physiology. 589 [PubMed]

Fortune ES, Rose GJ. (2000). Short-term synaptic plasticity contributes to the temporal filtering of electrosensory information. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Galarreta M, Hestrin S. (1998). Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nature neuroscience. 1 [PubMed]

Garwicz M, Ekerot CF. (1994). Topographical organization of the cerebellar cortical projection to nucleus interpositus anterior in the cat. The Journal of physiology. 474 [PubMed]

Gauck V, Jaeger D. (2003). The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Gauck V, Thomann M, Jaeger D, Borst A. (2001). Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Herz AV, Gollisch T, Machens CK, Jaeger D. (2006). Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science (New York, N.Y.). 314 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hoebeek FE, Khosrovani S, Witter L, De Zeeuw CI. (2008). Purkinje cell input to cerebellar nuclei in tottering: ultrastructure and physiology. Cerebellum (London, England). 7 [PubMed]

Hoebeek FE et al. (2005). Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control. Neuron. 45 [PubMed]

Hoebeek FE, Witter L, Ruigrok TJ, De Zeeuw CI. (2010). Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Izhikevich EM. (2006). Polychronization: computation with spikes. Neural computation. 18 [PubMed]

Izhikevich EM, Edelman GM. (2008). Large-scale model of mammalian thalamocortical systems. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Jaeger D, Gauck V. (2000). The role of intrinsic currents in determining the spike pattern of deep cerebellar nucleus neurons with synaptic input Soc Neurosci Abstr. 26:93.

Jagodic MM et al. (2007). Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Kistler WM, De Zeeuw CI. (2003). Time windows and reverberating loops: a reverse-engineering approach to cerebellar function. Cerebellum (London, England). 2 [PubMed]

Kistler WM, Leo van Hemmen J. (1999). Delayed reverberation through time windows as a key to cerebellar function. Biological cybernetics. 81 [PubMed]

Kistler WM, van Hemmen JL, De Zeeuw CI. (2000). Time window control: a model for cerebellar function based on synchronization, reverberation, and time slicing. Progress in brain research. 124 [PubMed]

Lin RJ, Jaeger D. (2011). Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. Journal of neurophysiology. 105 [PubMed]

Llinás R, Mühlethaler M. (1988). Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. The Journal of physiology. 404 [PubMed]

Luthman J et al. (2011). STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum (London, England). 10 [PubMed]

McCormick DA, Huguenard JR. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. Journal of neurophysiology. 68 [PubMed]

McCormick DA, Thompson RF. (1984). Cerebellum: essential involvement in the classically conditioned eyelid response. Science (New York, N.Y.). 223 [PubMed]

Medina JF, Garcia KS, Nores WL, Taylor NM, Mauk MD. (2000). Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Medina JF, Lisberger SG. (2009). Encoding and decoding of learned smooth-pursuit eye movements in the floccular complex of the monkey cerebellum. Journal of neurophysiology. 102 [PubMed]

Molineux ML et al. (2006). Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Molineux ML et al. (2008). Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. Journal of neurophysiology. 100 [PubMed]

Ozden I, Sullivan MR, Lee HM, Wang SS. (2009). Reliable coding emerges from coactivation of climbing fibers in microbands of cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Pape HC. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual review of physiology. 58 [PubMed]

Pedro SA, Abelman S, Ndjomatchoua FT, Sang R, Tonnang HE. (2014). Stability, bifurcation and chaos analysis of vector-borne disease model with application to Rift Valley fever. PloS one. 9 [PubMed]

Pedroarena CM, Schwarz C. (2003). Efficacy and short-term plasticity at GABAergic synapses between Purkinje and cerebellar nuclei neurons. Journal of neurophysiology. 89 [PubMed]

Person AL, Raman IM. (2011). Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature. 481 [PubMed]

Pugh JR, Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron. 51 [PubMed]

Raman IM, Gustafson AE, Padgett D. (2000). Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Robinson HP, Kawai N. (1993). Injection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons. Journal of neuroscience methods. 49 [PubMed]

Rothman JS, Cathala L, Steuber V, Silver RA. (2009). Synaptic depression enables neuronal gain control. Nature. 457 [PubMed]

Sangrey T, Jaeger D. (2010). Analysis of distinct short and prolonged components in rebound spiking of deep cerebellar nucleus neurons. The European journal of neuroscience. 32 [PubMed]

Sato Y, Miura A, Fushiki H, Kawasaki T. (1992). Short-term modulation of cerebellar Purkinje cell activity after spontaneous climbing fiber input. Journal of neurophysiology. 68 [PubMed]

Schultz SR, Kitamura K, Post-Uiterweer A, Krupic J, Häusser M. (2009). Spatial pattern coding of sensory information by climbing fiber-evoked calcium signals in networks of neighboring cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Sharp AA, O'Neil MB, Abbott LF, Marder E. (1993). Dynamic clamp: computer-generated conductances in real neurons. Journal of neurophysiology. 69 [PubMed]

Shin SL et al. (2007). Regular patterns in cerebellar Purkinje cell simple spike trains. PloS one. 2 [PubMed]

Silver RA. (2010). Neuronal arithmetic. Nature reviews. Neuroscience. 11 [PubMed]

Stern EA, Jaeger D, Wilson CJ. (1998). Membrane potential synchrony of simultaneously recorded striatal spiny neurons in vivo. Nature. 394 [PubMed]

Steuber V et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron. 54 [PubMed]

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

Tadayonnejad R et al. (2010). Rebound discharge in deep cerebellar nuclear neurons in vitro. Cerebellum (London, England). 9 [PubMed]

Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW. (2009). Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels (Austin, Tex.). 3 [PubMed]

Telgkamp P, Raman IM. (2002). Depression of inhibitory synaptic transmission between Purkinje cells and neurons of the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Tsodyks MV, Markram H. (1997). The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proceedings of the National Academy of Sciences of the United States of America. 94 [PubMed]

Uusisaari M, De Schutter E. (2011). The mysterious microcircuitry of the cerebellar nuclei. The Journal of physiology. 589 [PubMed]

Uusisaari M, Obata K, Knöpfel T. (2007). Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Journal of neurophysiology. 97 [PubMed]

Uusisaari MY, Knöpfel T. (2012). Diversity of neuronal elements and circuitry in the cerebellar nuclei. Cerebellum (London, England). 11 [PubMed]

Varela JA et al. (1997). A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Walter JT, Alviña K, Womack MD, Chevez C, Khodakhah K. (2006). Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nature neuroscience. 9 [PubMed]

Walter JT, Khodakhah K. (2006). The linear computational algorithm of cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Walter JT, Khodakhah K. (2009). The advantages of linear information processing for cerebellar computation. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Welsh JP, Lang EJ, Suglhara I, Llinás R. (1995). Dynamic organization of motor control within the olivocerebellar system. Nature. 374 [PubMed]

Wetmore DZ, Mukamel EA, Schnitzer MJ. (2008). Lock-and-key mechanisms of cerebellar memory recall based on rebound currents. Journal of neurophysiology. 100 [PubMed]

Zheng N, Raman IM. (2011). Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

References and models that cite this paper

Jaeger D et al. (2017). Robust Transmission of Rate Coding in the Inhibitory Purkinje Cell to Cerebellar Nuclei Pathway in Awake Mice PLOS Computational Biology.

Ovsepian SV et al. (2013). A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. The Journal of physiology. 591 [PubMed]

De Schutter E, Jaeger D, Steuber V. (2004). Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors Neurocomputing. 58-60

See more from authors: De Schutter E · Jaeger D · Steuber V

References and models cited by this paper

Batini C, Compoint C, Buisseret-Delmas C, Daniel H, Guegan M. (1992). Cerebellar nuclei and the nucleocortical projections in the rat: retrograde tracing coupled to GABA and glutamate immunohistochemistry. The Journal of comparative neurology. 315 [PubMed]

Bower JM, Beeman D. (1998). The Book Of Genesis: Exploring Realistic Neural Models With The General Neural Simulation System.

Chan-Palay V. (1977). Cerebellar Dentate Nucleus: Organization, Cytology, and Transmitters.

Hellwig B. (2000). A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex. Biological cybernetics. 82 [PubMed]

Jaeger D. (2001). Accurate reconstruction of neuronal morphology Computational Neuroscience: Realistic Modeling For Experimentalists.

Major G. (2001). Passive cable modelling a practical introduction Computational Neuroscience: Realistic Modelling for Experimentalists.

Major G, Larkman AU, Jonas P, Sakmann B, Jack JJ. (1994). Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 14 [PubMed]

Rapp M, Segev I, Yarom Y. (1994). Physiology, morphology and detailed passive models of guinea-pig cerebellar Purkinje cells. The Journal of physiology. 474 [PubMed]

Roth A, Häusser M. (2001). Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings. The Journal of physiology. 535 [PubMed]

Sultan F, Czubayko U, Thier P. (2003). Morphological classification of the rat lateral cerebellar nuclear neurons by principal component analysis. The Journal of comparative neurology. 455 [PubMed]

References and models that cite this paper

Lin RJ, Jaeger D. (2011). Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. Journal of neurophysiology. 105 [PubMed]

Ovsepian SV et al. (2013). A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. The Journal of physiology. 591 [PubMed]

Perreault MC, Raastad M. (2006). Contribution of morphology and membrane resistance to integration of fast synaptic signals in two thalamic cell types. The Journal of physiology. 577 [PubMed]

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

Luthman J et al. (2011). STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum (London, England). 10 [PubMed]

See more from authors: Luthman J · Hoebeek FE · Maex R · Davey N · Adams R · De Zeeuw CI · Steuber V

References and models cited by this paper

Abbott LF, Regehr WG. (2004). Synaptic computation. Nature. 431 [PubMed]

Abbott LF, Varela JA, Sen K, Nelson SB. (1997). Synaptic depression and cortical gain control. Science (New York, N.Y.). 275 [PubMed]

Aizenman CD, Linden DJ. (1999). Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. Journal of neurophysiology. 82 [PubMed]

Alviña K, Khodakhah K. (2008). Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats. The Journal of physiology. 586 [PubMed]

Alviña K, Walter JT, Kohn A, Ellis-Davies G, Khodakhah K. (2008). Questioning the role of rebound firing in the cerebellum. Nature neuroscience. 11 [PubMed]

Anchisi D, Scelfo B, Tempia F. (2001). Postsynaptic currents in deep cerebellar nuclei. Journal of neurophysiology. 85 [PubMed]

Armstrong DM, Rawson JA. (1979). Activity patterns of cerebellar cortical neurones and climbing fibre afferents in the awake cat. The Journal of physiology. 289 [PubMed]

Borst JG. (2010). The low synaptic release probability in vivo. Trends in neurosciences. 33 [PubMed]

Bower JM, Beeman D. (1998). The Book Of Genesis: Exploring Realistic Neural Models With The General Neural Simulation System.

Chance FS, Nelson SB, Abbott LF. (1998). Synaptic depression and the temporal response characteristics of V1 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Chung YH, Shin C, Park KH, Cha CI. (2000). Immunohistochemical study on the distribution of the voltage-gated calcium channel alpha(1B) subunit in the mature rat brain. Brain research. 866 [PubMed]

Czubayko U, Sultan F, Thier P, Schwarz C. (2001). Two types of neurons in the rat cerebellar nuclei as distinguished by membrane potentials and intracellular fillings. Journal of neurophysiology. 85 [PubMed]

Daniel H, Billard JM, Angaut P, Batini C. (1987). The interposito-rubrospinal system. Anatomical tracing of a motor control pathway in the rat. Neuroscience research. 5 [PubMed]

De Schutter E, Steuber V. (2009). Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theory. Neuroscience. 162 [PubMed]

De Zeeuw CI, Berrebi AS. (1995). Postsynaptic targets of Purkinje cell terminals in the cerebellar and vestibular nuclei of the rat. The European journal of neuroscience. 7 [PubMed]

De Zeeuw CI, Hoebeek FE, Schonewille M. (2008). Causes and consequences of oscillations in the cerebellar cortex. Neuron. 58 [PubMed]

De Zeeuw CI, Wylie DR, DiGiorgi PL, Simpson JI. (1994). Projections of individual Purkinje cells of identified zones in the flocculus to the vestibular and cerebellar nuclei in the rabbit. The Journal of comparative neurology. 349 [PubMed]

Dunlap K, Turner TJ, Zhou YD. (2003). Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering. J Physiol. 547

Fletcher CF et al. (1996). Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell. 87 [PubMed]

Fortune ES, Rose GJ. (2000). Short-term synaptic plasticity contributes to the temporal filtering of electrosensory information. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Fortune ES, Rose GJ. (2001). Short-term synaptic plasticity as a temporal filter. Trends in neurosciences. 24 [PubMed]

Fredette BJ, Mugnaini E. (1991). The GABAergic cerebello-olivary projection in the rat. Anatomy and embryology. 184 [PubMed]

GREEN MC, SIDMAN RL. (1962). Tottering--a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism. The Journal of heredity. 53 [PubMed]

Galarreta M, Hestrin S. (1998). Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nature neuroscience. 1 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. I. Postsynaptic potentials. Brain research. 351 [PubMed]

Gardette R, Debono M, Dupont JL, Crepel F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. II. Membrane conductances. Brain research. 352 [PubMed]

Gauck V, Jaeger D. (2003). The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Goossens J et al. (2001). Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affecting Purkinje cell excitability in alert mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Hille B. (2001). Ionic Channels of Excitable Membranes.

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hoebeek FE, Khosrovani S, Witter L, De Zeeuw CI. (2008). Purkinje cell input to cerebellar nuclei in tottering: ultrastructure and physiology. Cerebellum (London, England). 7 [PubMed]

Hoebeek FE et al. (2005). Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control. Neuron. 45 [PubMed]

Hoebeek FE, Witter L, Ruigrok TJ, De Zeeuw CI. (2010). Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Holt GR, Softky WR, Koch C, Douglas RJ. (1996). Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons. Journal of neurophysiology. 75 [PubMed]

Isaacs KR, Abbott LC. (1992). Development of the paramedian lobule of the cerebellum in wild-type and tottering mice. Developmental neuroscience. 14 [PubMed]

Jones MV, Westbrook GL. (1996). The impact of receptor desensitization on fast synaptic transmission. Trends in neurosciences. 19 [PubMed]

Kahlon M, Lisberger SG. (2000). Changes in the responses of Purkinje cells in the floccular complex of monkeys after motor learning in smooth pursuit eye movements. Journal of neurophysiology. 84 [PubMed]

Loewenstein Y et al. (2005). Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Nature neuroscience. 8 [PubMed]

Matsushita K et al. (2002). Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Meier H, MacPike AD. (1971). Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice. The Journal of heredity. 62 [PubMed]

Monsivais P, Clark BA, Roth A, Häusser M. (2005). Determinants of action potential propagation in cerebellar Purkinje cell axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Murphy JT, Sabah NH. (1970). Spontaneous firing of cerebellar Purkinje cells in decerebrate and barbiturate anesthetized cats. Brain research. 17 [PubMed]

Otis T, Zhang S, Trussell LO. (1996). Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Otis TS, Mody I. (1992). Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons. Neuroscience. 49 [PubMed]

Palkovits M, Mezey E, Hámori J, Szentágothai J. (1977). Quantitative histological analysis of the cerebellar nuclei in the cat. I. Numerical data on cells and on synapses. Experimental brain research. 28 [PubMed]

Pedroarena CM. (2010). Mechanisms supporting transfer of inhibitory signals into the spike output of spontaneously firing cerebellar nuclear neurons in vitro. Cerebellum (London, England). 9 [PubMed]

Pedroarena CM, Schwarz C. (2003). Efficacy and short-term plasticity at GABAergic synapses between Purkinje and cerebellar nuclei neurons. Journal of neurophysiology. 89 [PubMed]

Pugh JR, Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron. 51 [PubMed]

Pugh JR, Raman IM. (2008). Mechanisms of potentiation of mossy fiber EPSCs in the cerebellar nuclei by coincident synaptic excitation and inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Rhyu IJ, Abbott LC, Walker DB, Sotelo C. (1999). An ultrastructural study of granule cell/Purkinje cell synapses in tottering (tg/tg), leaner (tg(la)/tg(la)) and compound heterozygous tottering/leaner (tg/tg(la)) mice. Neuroscience. 90 [PubMed]

Rothman JS, Cathala L, Steuber V, Silver RA. (2009). Synaptic depression enables neuronal gain control. Nature. 457 [PubMed]

Sawada K, Sakata-Haga H, Ando M, Takeda N, Fukui Y. (2001). An increased expression of Ca(2+) channel alpha(1A) subunit immunoreactivity in deep cerebellar neurons of rolling mouse Nagoya. Neuroscience letters. 316 [PubMed]

Shin SL et al. (2007). Regular patterns in cerebellar Purkinje cell simple spike trains. PloS one. 2 [PubMed]

Shin SL, Rotter S, Aertsen A, De Schutter E. (2007). Stochastic description of complex and simple spike firing in cerebellar Purkinje cells. The European journal of neuroscience. 25 [PubMed]

Silver RA. (2010). Neuronal arithmetic. Nature reviews. Neuroscience. 11 [PubMed]

Silver RA, Colquhoun D, Cull-Candy SG, Edmonds B. (1996). Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells. The Journal of physiology. 493 ( Pt 1) [PubMed]

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. (2011). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. Journal of computational neuroscience. 30 [PubMed]

Sultan F, Czubayko U, Thier P. (2003). Morphological classification of the rat lateral cerebellar nuclear neurons by principal component analysis. The Journal of comparative neurology. 455 [PubMed]

Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW. (2009). Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels (Austin, Tex.). 3 [PubMed]

Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM. (2004). Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron. 41 [PubMed]

Telgkamp P, Raman IM. (2002). Depression of inhibitory synaptic transmission between Purkinje cells and neurons of the cerebellar nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Teune TM, van der Burg J, van der Moer J, Voogd J, Ruigrok TJ. (2000). Topography of cerebellar nuclear projections to the brain stem in the rat. Progress in brain research. 124 [PubMed]

Tsodyks MV, Markram H. (1997). The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proceedings of the National Academy of Sciences of the United States of America. 94 [PubMed]

Uusisaari M, Knöpfel T. (2008). GABAergic synaptic communication in the GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Neuroscience. 156 [PubMed]

Uusisaari M, Knöpfel T. (2010). GlyT2+ neurons in the lateral cerebellar nucleus. Cerebellum (London, England). 9 [PubMed]

Uusisaari M, Obata K, Knöpfel T. (2007). Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Journal of neurophysiology. 97 [PubMed]

Varela JA et al. (1997). A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Wakamori M et al. (1998). Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel. The Journal of biological chemistry. 273 [PubMed]

Walter JT, Alviña K, Womack MD, Chevez C, Khodakhah K. (2006). Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nature neuroscience. 9 [PubMed]

Zucker RS. (1989). Short-term synaptic plasticity. Annual review of neuroscience. 12 [PubMed]

Zucker RS. (1999). Calcium- and activity-dependent synaptic plasticity. Current opinion in neurobiology. 9 [PubMed]

References and models that cite this paper

Ovsepian SV et al. (2013). A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. The Journal of physiology. 591 [PubMed]

Steuber V, Jaeger D. (2013). Modeling the generation of output by the cerebellar nuclei. Neural networks : the official journal of the International Neural Network Society. 47 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.